Antibacterial Activity of Amine-Functionalized Silver-Loaded Natural Zeolite Clinoptilolite

Abstract

The antibacterial activity of amine-functionalized silver-loaded natural zeolite clinoptilolite was analysed against Gram-negative Escherichia coli ATCC 11229 and a comparison was made with raw clinoptilolite, silver-loaded clinoptilolite, and amine-functionalized clinoptilolite with APTES (3-Aminopropyl) triethoxysilane. Results from the characterization of the samples using Fourier transform infrared (FTIR) spectroscopy showed that the silver-loaded clinoptilolite was functionalized with APTES without affecting the original framework structure of the clinoptilolite. The antibacterial activity of the analysed samples based on disc diffusion technique (DDT) and minimum inhibition concentration (MIC) showed that the silver-loaded clinoptilolite (150 % of cation exchange capacity of clinoptilolite) had the highest antibacterial activity, as compared to amine-functionalized silver-loaded zeolite. This study showed that the functionalization of silver-loaded clinoptilolite could affect the release and action of silver ions to kill or inhibit bacterial growth. However, it showed that the natural zeolite clinoptilolite could become a good carrier system for the antibacterial metal ion, especially silver ions. 
 Keywords: Zeolite, clinoptilolite, antibacterial agent, silver, amine-functionalization 

HNT-Cellulose based Nano-Composite and Applications

“…There are various methods of functionalization of the surface of HNT. Researchers have worked on the functionalization of silver-exchanged zeolite (NaY) using 3-amino propyl trimethoxy silane (APTES) with amine that could improve the activity against bacteria against S. aureus and E. coli [18]. Silvers show the strong antibacterial activity against various bacteria easily incorporated into the surface of HNT.…”