Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Kurishima, Hiroaki; Mori, Yu; Inoue, Hiroyuki; Mokudai, Takayuki; Fujimori, Satoko; Itoi, Eiji; Hanada, Shuji; Masahashi, Naoya; Aizawa, Tadanori

doi:10.3389/fbioe.2022.883335

Cited by 11 publications

(12 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Osteoblast progenitor cells are expressed in the endosteum of the bone marrow [36]. The TNS alloy after anodic oxidation treatment promotes bone formation by proliferating and activating osteoblasts in the endosteum of the bone and exerts an antibacterial effect through photocatalytic performance owing to sodium tartrate [48,49]. The TNS alloy is considered to be a promising orthopaedic implant material owing to the low Young's modulus and functional improvement by surface modi cation.…”

Section: Discussionmentioning

confidence: 99%

TiNbSn stems with gradient changes of Young’s modulus and stiffness prevent stress shielding compared to similarly designed stems

Baba

Mori

Chiba

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Background The difference between Young’s moduli of the femur and the stem causes stress shielding (SS). TiNbSn (TNS) stem has a low Young’s modulus and strength with gradient functional properties during the change in elastic modulus with heat treatment. The aim of this study was to investigate the inhibitory effect of TNS stems on SS and their clinical outcomes compared to conventional stems. Methods This study was a clinical trial. Primary THA was performed using a TNS stem from April 2016 to September 2017 for patients in the TNS group. Unilateral THA was performed using a Ti6Al4V alloy stem from January 2007 to February 2011 for patients in the control group. The TNS and Ti6Al4V stems were matched in shape. Radiographs were obtained at the 1- and 3-year follow-ups. Two surgeons independently checked the SS grade and appearance of cortical hypertrophy (CH). The Japanese Orthopaedic Association (JOA) scores before and 1 year after surgery were assessed as clinical scores. Results None of the patients in the TNS group had grade 3 or 4 SS. In contrast, in the control group, 24% and 40% of patients had grade 3 and 4 SS at the 1- and 3-year follow-ups, respectively. The SS grade was lower in the TNS group than in the control group at the 1- and 3-year follow-ups (p < 0.001). The frequencies of CH in both groups were no significant difference at the 1- and 3- year follow-ups. The JOA scores of the TNS group significantly improved at 1 year after surgery and were comparable to control group. Conclusion The TNS stem prevented SS at 1 and 3 years after THA compared to the proximal-engaging cementless stem, although the shapes of the stems matched. The TNS stem could prevent SS, stem loosening, and periprosthetic fractures. Trial registration: Current Controlled Trials ISRCTN21241251. https://www.isrctn.com/search?q=21241251 The date of registration was October 26, 2021. Retrospectively registered.

show abstract

Section: Discussionmentioning

confidence: 99%

TiNbSn stems with gradient changes of Young’s modulus and stiffness prevent stress shielding compared to similarly designed stems

Baba

Mori

Chiba

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The intensity of the radiated light was 1.0 mW/cm 2 at the surface of the cell comprising the MB solution (3.19 ppm) and anodized alloy. The photocatalytic activity was evaluated by measuring the absorbance of MB at 664 nm using a UV-vis spectrophotometer (Jasco V-550, JASCO Corporation, Tokyo, Japan) [ 25 , 30 ]. The photogenerated hydroxyl radicals (•OH) react with terephthalic acid (TA) in a disodium terephthalate (NaTA) solution, thereby producing 2-hydroxyterephthalic acid (HTA) via a hydroxylation reaction, as shown in the following Equation (1): C 6 H 4 (COOH) 2 + •OH→C 6 H 4 (COOH) 2 OH …”

Section: Methodsmentioning

confidence: 99%

“…Anodic oxides, prepared using the electrolytes of acetic or sulfuric acid aqueous solutions, improved the osseointegration owing to the formation of hydroxyapatite in an experimental model, thereby demonstrating the efficacy of the surface improvement on the biocompatibility of TiNbSn alloys [ 19 , 20 , 21 , 22 , 23 ]. Furthermore, the photocatalytic and antimicrobial activities under UV illumination were confirmed in the anodized TiNbSn alloys, prepared in an electrolyte of sodium tartrate aqueous solution [ 24 , 25 ]. In previous studies, clinical and preclinical studies have shown that the low Young’s modulus of TiNbSn alloys improves stress shielding, which is useful in reducing bone atrophy and promoting bone healing.…”

Section: Introductionmentioning

confidence: 99%

“…A few studies reported the antimicrobial activity of the anodized Ti alloys owing to their photocatalytic activities [ 25 , 28 ]. The improvement in the bone conductivity of the anodized TiNbSn alloy, prepared in the sulfuric acid electrolyte, was confirmed [ 21 , 22 ]; however, the antimicrobial activity of the anodized TiNbSn alloy has not been verified yet.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antimicrobial Properties of TiNbSn Alloys Anodized in a Sulfuric Acid Electrolyte

et al. 2023

Self Cite

View full text Add to dashboard Cite

TiNbSn alloy is a high-performance titanium alloy which is biosafe, strong, and has a low Young’s modulus. TiNbSn alloy has been clinically applied as a material for orthopedic prosthesis. Anodized TiNbSn alloys with acetic and sulfuric acid electrolytes have excellent biocompatibility for osseointegration. Herein, TiNbSn alloy was anodized in a sulfuric acid electrolyte to determine the antimicrobial activity. The photocatalytic activities of the anodic oxide alloys were investigated based on their electronic band structure and crystallinity. In addition, the cytotoxicity of the anodized TiNbSn alloy was evaluated using cell lines of the osteoblast and fibroblast lineages. The antimicrobial activity of the anodic oxide alloy was assessed according to the ISO 27447 using methicillin-susceptible Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, and Escherichia coli. The anodic oxide comprised rutile and anatase titanium dioxide (TiO2) and exhibited a porous microstructure. A well-crystallized rutile TiO2 phase was observed in the anodized TiNbSn alloy. The methylene blue degradation tests under ultraviolet illumination exhibited photocatalytic activity. In antimicrobial tests, the anodized TiNbSn alloy exhibited robust antimicrobial activities under ultraviolet illumination for all bacterial species, regardless of drug resistance. Therefore, the anodized TiNbSn alloy can be used as a functional biomaterial with low Young’s modulus and excellent antimicrobial activity.

show abstract

“…The photocatalytic and antibacterial performances of anodized TiNbSn alloys prepared in an electrolyte of sodium tartrate acid have been studied [ 68 , 69 , 70 , 71 ]. In the development of antibacterial metals, antibacterial metal ions, such as silver and copper, and antibacterial agents, such as iodine and vancomycin, have been used [ 72 , 73 , 74 , 75 ].…”

Section: Photocatalytic Activity Of Anodized Tinbsn Alloymentioning

confidence: 99%

A Review of Anodized TiNbSn Alloys for Improvement in Layer Quality and Application to Orthopedic Implants

2022

Self Cite

View full text Add to dashboard Cite

Titanium alloys are useful for application in orthopedic implants. However, complications, such as prosthetic infections and aseptic loosening, often occur after orthopedic devices are implanted. Therefore, innovation in surface modification techniques is essential to develop orthopedic materials with optimal properties at the biomaterial–bone interface. In this review, we present recent research on the improvement in the osteoconductivity and antibacterial effect of the Ti-33.6% Nb-4% Sn (TiNbSn) alloy by anodic oxidation and other related studies. TiNbSn alloys are excellent new titanium alloys with a low Young’s modulus, high tensile strength, and with gradient functional properties such as a thermally adjustable Young’s modulus and strength. Titanium dioxide (TiO2), when obtained by the anodic oxidation of a TiNbSn alloy, improves bone affinity and provides antibacterial performance owing to its photocatalytic activity. The safety of TiO2 and its strong bonding with metal materials make its method of preparation a promising alternative to conventional methods for improving the surface quality of orthopedic implants. Implementing anodization technology for TiNbSn alloys may alleviate orthopedic surgery-related complications, such as loosening, stress shielding, and infection after arthroplasty.

show abstract

Antibacterial Activity of an Anodized TiNbSn Alloy Prepared in Sodium Tartrate Electrolyte

Cited by 11 publications

References 39 publications

TiNbSn stems with gradient changes of Young’s modulus and stiffness prevent stress shielding compared to similarly designed stems

TiNbSn stems with gradient changes of Young’s modulus and stiffness prevent stress shielding compared to similarly designed stems

Antimicrobial Properties of TiNbSn Alloys Anodized in a Sulfuric Acid Electrolyte

A Review of Anodized TiNbSn Alloys for Improvement in Layer Quality and Application to Orthopedic Implants

Contact Info

Product

Resources

About