Antibacterial activity of bioactive compounds extracted from red kidney bean (Phaseolus vulgaris L.) seeds against multidrug-resistant Enterobacterales

Ebrahim, Azhar E.; El-Aziz, Norhan K. Abd; Elariny, Eman Y. T.; Shindia, Ahmed A.; Osman, Ali; Hozzein, Wael N.; Alkhalifah, Dalal Hussien M.; El-Hossary, Dalia

doi:10.3389/fmicb.2022.1035586

Cited by 9 publications

(3 citation statements)

References 71 publications

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“…For example, zeaxin‐o‐glucosyltransferase (ZOG 1) mainly uses UDP‐Glc as a glycosylated donor, while tamicin‐o‐xylosyltransferase (ZOX1) exclusively uses UDP‐Xyl as a glycosylated donor. Now two genes, ZOG1 and ZOX1, have been isolated from kidney beans (Ebrahim et al, 2022; Tormo et al, 2004), and the map of UDP‐Glc binding sites has been drawn through domain swap experiments. Cis‐zeosin‐o‐glucosyltransferase (cis‐ZOG 1) has also been isolated (Martin et al, 2001; Veach et al, 2003), which is highly specific to the cis‐isomer and specifically glycosylates cis‐zeosin.…”

Section: Ctk Metabolism Transport and Signal Transductionmentioning

confidence: 99%

Influence of cultivation practices on the metabolism of cytokinin and its correlation in rice production

Saud

Cai

et al. 2023

Food and Energy Security

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Cytokinin (CTK) has an important regulatory effect on plant morphology, physiology, and yield, and is one of the main factors regulating nitrogen absorption, transport, and metabolism. This paper reviews the research progress in nitrogen absorption, transport and metabolism, cytokinin synthesis, transport and signal transduction, etc., focusing on the physiological mechanisms by which CTK and nitrogen collaborate to regulate the root–shoot relationship and its impact on agronomic traits of crops. The synthesis of trans‐zeatin (tZ) and trans‐zeatin riboside (tZR) is generally regulated by root nitrogen, which is transported them to the sprouts, regulates nitrogen allocation and metabolism, and affects photosynthetic characteristics and yield. In young shoots, nitrogen upregulates the synthesis of isopentenyl, adenine (iP), and iP‐nucleoside (iPR) and transports to roots through the phloem, reducing nitrogen uptake and transport, affecting root morphology. Based on this, the role of, CTK in coordinating relationships between source repositories and enhancing injection. We conducted an analysis on how various cultivation methods impact CTK metabolism and its relationship with plant growth. Additionally, we discussed the challenges associated with applying CTK functions to paddy field production and suggested future research directions.

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Section: Ctk Metabolism Transport and Signal Transductionmentioning

confidence: 99%

Influence of cultivation practices on the metabolism of cytokinin and its correlation in rice production

Saud

Cai

et al. 2023

Food and Energy Security

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“…The incidence of morbidity and mortality resulting from drug-resistant diseases is increasing globally ( Serwecińska, 2020 ). For this reason, the search for new antimicrobials from natural sources is crucial in modern medicine to combat the socioeconomic impact and health consequences of multidrug-resistant bacteria ( Mahgoub, Sitohy & Osman, 2013 ; El-Beltagi et al, 2019 ; Ebrahim et al, 2022 ; Fekry et al, 2022 ). Consequently, the advancement of newer antimicrobial medications necessitates the adoption of a creative approach ( Abdel-Shafi et al, 2016 ; Abdel-Shafi et al, 2019a ; Abdel-Shafi et al, 2019b ; Abdel-Hamid et al, 2020b ; Al-Mohammadi et al, 2020 ; Osman et al, 2021a ; Abdel-Shafi et al, 2022 ; Enan et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of zinc oxide nanoparticles via neem extract and their anticancer and antibacterial activities

El-Beltagi,

Ragab,

Osman

et al. 2024

PeerJ

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In the present study, zinc oxide nanoparticles (ZnO-NPs) were synthesized using neem leaf aqueous extracts and characterized using transmission electron microscopy (TEM), ultraviolet visible spectroscopy (UV-Vis), and dynamic light scattering (DLS). Then compare its efficacy as anticancer and antibacterial agents with chemically synthesized ZnO-NPs and the neem leaf extract used for the green synthesis of ZnO-NPs. The TEM, UV-vis, and particle size confirmed that the developed ZnO-NPs are nanoscale. The chemically and greenly synthesized ZnO-NPs showed their optical absorbance at 328 nm and 380 nm, respectively, and were observed as spherical particles with a size of about 85 nm and 62.5 nm, respectively. HPLC and GC-MS were utilized to identify the bioactive components in the neem leaf aqueous extract employed for the eco-friendly production of ZnO-NPs. The HPLC analysis revealed that the aqueous extract of neem leaf contains 19 phenolic component fractions. The GC-MS analysis revealed the existence of 21 bioactive compounds. The antiproliferative effect of green ZnO-NPs was observed at different concentrations (31.25 µg/mL–1000 µg/mL) on Hct 116 and A 549 cancer cells, with an IC50 value of 111 µg/mL for A 549 and 118 µg/mL for Hct 116. On the other hand, the antibacterial activity against gram-positive and gram-negative bacteria was estimated. The antibacterial result showed that the MIC of green synthesized ZnO-NPs against gram-positive and gram-negative bacteria were 5, and 1 µg/mL. Hence, they could be utilized as effective antibacterial and antiproliferative agents.

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“…For several years, basic proteins, spices, herbs, and herbal extracts with antimicrobial activities have been thoroughly and widely discussed (Abdel-Shafi et al, 2019b ; Imbabi et al, 2021 ; Osman et al, 2021 ; Ebrahim et al, 2022 ; Mahmoud et al, 2023 ). Plant biodiversity provides an essential source of chemical compounds with variable and diversified multiple therapeutic applications, including antiviral, antibacterial, antifungal, and anticancer activities (Osman et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Controlling bacterial biofilm formation by native and methylated lupine 11S globulins

Enan,

Abdel-Shafi,

El-Nemr

et al. 2023

Front. Microbiol.

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The antibacterial and anti-biofilm activities of the 11S globulins isolated from lupin seeds (Lupinus termis), and its methylated derivative (M11S), were investigated against seven pathogenic gram-positive and gram-negative bacteria. The MIC of 11S ranged from 0.1 to 4.0 μg/ml against 0.025 to 0.50 μg/ml for M11S, excelling some specific antibiotics. The MICs of M11S were 40–80 times lower than some specific antibiotics against gram-positive bacteria and 2–60 times lower than some specific antibiotics against gram-negative bacteria. One MIC of 11S and M11S highly reduced the liquid growth of all tested bacteria during 24 h at 37°C. They also inhibited biofilm formation by 80%−86% and 85%−94%, respectively (gram-positive), and 29%−44% and 43%−50%, respectively (gram-negative). M11S prevented biofilm formation by gram-positive bacteria at minimum biofilm inhibitory concentration (MBIC), 0.025–0.1 μg/ml against 0.1–0.5 μg/ml for gram-negative bacteria, i.e., 4–20 times and 4–7 times anti-biofilm inhibitory action compared with 11S, respectively. Biofilm formation of two bacteria revealed no adhered cells on glass slides for 24 h at 37°C, i.e., was entirely prevented by one MBIC of 11S and M11S. Scanning electron microscopy indicated microbial biofilm deformation under the action of 11S and M11S, indicating their broad specificity and cell membrane-targeted action.

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Antibacterial activity of bioactive compounds extracted from red kidney bean (Phaseolus vulgaris L.) seeds against multidrug-resistant Enterobacterales

Cited by 9 publications

References 71 publications

Influence of cultivation practices on the metabolism of cytokinin and its correlation in rice production

Influence of cultivation practices on the metabolism of cytokinin and its correlation in rice production

Biosynthesis of zinc oxide nanoparticles via neem extract and their anticancer and antibacterial activities

Controlling bacterial biofilm formation by native and methylated lupine 11S globulins

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