Antibacterial activity of chemical constituents isolated from &lt;i&gt;Asparagus racemosus&lt;/i&gt;

Shah, Muhammad Abdullah; Abdullah, Syed Muhammad; Khan, Majid; Nasar, Gulfam; Saba, Irum

doi:10.3329/bjp.v9i1.16672

Cited by 13 publications

(10 citation statements)

References 15 publications

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“…Shatavari has been reported for its anti-bacterial, anti-candidal, anti-viral activities (Mandal et al, 2000;Raza et al, 2015;Shah et al, 2014;Uma et al, 2009) . Recent studies have reported that, the drug under investigation, if possess a potent immunomodulatory, anti-inflammatory and antioxidant potential could prove an effective agent in treatment of COVID 19 (Jayawardena et al, 2020;Patwardhan et al, 2020;Tillu et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

In-silicoinvestigation of phytochemicals fromAsparagus racemosusas plausible antiviral agent in COVID-19

Chikhale

Sinha

Patil

et al. 2020

Journal of Biomolecular Structure and Dynamics

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COVID-19 has ravaged the world and is the greatest of pandemics in human history, in the absence of treatment or vaccine the mortality and morbidity rates are very high. The present investigation was undertaken to screen and identify the potent leads from the Indian Ayurvedic herb, Asparagus racemosus (Willd.) against SARS-CoV-2 using molecular docking and dynamics studies. The docking analysis was performed on the Glide module of Schr€ odinger suite on two different proteins from SARS-CoV-2 viz. NSP15 Endoribonuclease and spike receptor-binding domain. Asparoside-C, Asparoside-D and Asparoside -F were found to be most effective against both the proteins as confirmed through their docking score and affinity. Further, the 100 ns molecular dynamics study also confirmed the potential of these compounds from reasonably lower root mean square deviations and better stabilization of Asparoside-C and Asparoside-F in spike receptor-binding domain and NSP15 Endoribonuclease respectively. MM-GBSA based binding free energy calculations also suggest the most favourable binding affinities of Asparoside-C and Asparoside-F with binding energies of À62.61 and À55.19 Kcal/mol respectively with spike receptor-binding domain and NSP15 Endoribonuclease. HIGHLIGHTSAsparagus racemosus have antiviral potential Phytochemicals of Shatavari showed promising in-silico docking and MD results Asparaoside-C and Asparoside-F has good binding with target proteins Asparagus racemosus holds promise as SARS-COV-2 (S) and (N) proteins inhibitor

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Section: Introductionmentioning

confidence: 99%

In-silicoinvestigation of phytochemicals fromAsparagus racemosusas plausible antiviral agent in COVID-19

Chikhale

Sinha

Patil

et al. 2020

Journal of Biomolecular Structure and Dynamics

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“…Significantly ( p < 0.05) lower counts of the products incorporated with A. racemosus on all intervals of storage may be attributed to the bioactive and phenolic constituents of A. racemosus (Shah et al , 2014). Phenolic and flavonoid compounds of the plant extracts are responsible for their antioxidant and antibacterial properties (Hossain et al , 2012; Majhenic et al , 2007).…”

Section: Resultsmentioning

confidence: 97%

Asparagus racemosus

Noor

Kumar

Kousar

2017

NFS

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Purpose This paper aims to explore the possibility of utilization of Asparagus racemosus as a novel natural preservative in meat products. Design/methodology/approach Chevon sausages were used as a study model and prepared by incorporating different levels of A. racemosus, namely, T1 (0.25 per cent), T2 (0.50 per cent) and T3 (0.75 per cent) and were vacuum packaged and assessed for various lipid oxidative stability and storage quality parameters under refrigerated (4 ± 1°C) conditions. Findings Significantly (p < 0.05) lower thiobarbituric acid reacting substances (mg malonaldehyde/kg) values were observed for the products containing A. racemosus in comparison to control indicating a significant effect on the lipid oxidative stability. The products containing A. racemosus also showed significantly (p < 0.05) lower values for various microbiological characteristics like total plate count (log cfu/g), psychrophilic count (log cfu/g), yeast and mould count (log cfu/g), anaerobic count (log cfu/g) and free fatty acid (% oleic acid) values indicating the antimicrobial and antifungal properties of A. racemosus. No significant (p > 0.05) effect was observed on the cooking yield and moisture content of the products. Significantly (p < 0.05) higher scores were observed for various sensory parameters of the products containing A. racemosus during the entire period of storage. Originality/value A. racemosus successfully improved the lipid oxidative stability and storage quality of the model meat product without compromising the sensorial characteristics and has a great potential as a novel natural preservative in muscle foods.

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“…Iso-agatharesinol and gobicusin A ( Figure 7) are also able to exert these effects. In particular, gobicusin A is a better antibacterial compound against Escherichia coli and Staphylococcus aureus than iso-agatharesinol given its MIC values (0.12 and 0.05 mg/mL vs. 0.25 and 0.12 mg/mL, respectively) and its efficacy is extremely comparable to streptomycin especially against Staphylococcus aureus (MIC = 0.01 mg/mL) [19].…”

Section: Antifungal and Antibacterialmentioning

confidence: 99%

Nor-Lignans: Occurrence in Plants and Biological Activities—A Review

et al. 2020

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In this review article, the occurrence of nor-lignans and their biological activities are explored and described. Nor-lignans have proven to be present in several different families also belonging to chemosystematically distant orders as well as to have many different beneficial pharmacological activities. This review article represents the first one on this argument and is thought to give a first overview on these compounds with the hope that their study may continue and increase, after this.

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Antibacterial activity of chemical constituents isolated from <i>Asparagus racemosus</i>

Cited by 13 publications

References 15 publications

In-silicoinvestigation of phytochemicals fromAsparagus racemosusas plausible antiviral agent in COVID-19

In-silicoinvestigation of phytochemicals fromAsparagus racemosusas plausible antiviral agent in COVID-19

Asparagus racemosus

Nor-Lignans: Occurrence in Plants and Biological Activities—A Review

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