Antibacterial Activity of Contact Lenses Bearing Surface-Immobilized Layers of Intact Liposomes Loaded With Levofloxacin

Danion, Anne; Arsenault, Isabelle; Vermette, Patrick

doi:10.1002/jps.20871

Cited by 85 publications

(58 citation statements)

References 35 publications

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“…23 Liposomes containing lidocaine have been immobilized onto the surface of the contact lens in one or more layers. 20,21 A study found that contact lenses coated with 10 layers of liposomes released about 5 times more drug than corresponding lenses coated with only 2 layers of levofloxacin-containing liposomes. Both were characterized by an initial 5-hour burst with little subsequent drug release; 40 µg was released over 6 days.…”

Section: Drug Uptake and Release From Pre-formed Contact Lensesmentioning

confidence: 98%

“…20,21 Liposomes, spherical vesicles of lipid bilayers with an aqueous core, 22 have been shown to increase the drug's contact time with the eye's surface when applied in the form of a topical solution. 23 Liposomes containing lidocaine have been immobilized onto the surface of the contact lens in one or more layers.…”

Section: Drug Uptake and Release From Pre-formed Contact Lensesmentioning

confidence: 99%

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Contact Lenses for Drug Delivery

Ciolino

Dohlman

Kohane

2009

Seminars in Ophthalmology

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The majority of ocular medications are delivered to the eye topically, often in the form of a solution, or eye drop. Contact lenses could potentially also be used to deliver medications to the eye. Recently, progress has been made in developing a drug-eluting contact lens. Different designs have been proposed and several offer the hope of expanding the therapeutic armamentarium for eye care providers.

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Section: Drug Uptake and Release From Pre-formed Contact Lensesmentioning

confidence: 98%

Section: Drug Uptake and Release From Pre-formed Contact Lensesmentioning

confidence: 99%

Contact Lenses for Drug Delivery

Ciolino

Dohlman

Kohane

2009

Seminars in Ophthalmology

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“…Several types of nanoparticles such as liposomes or lipid-based nanoparticles [210, 213, 218–220], micelles [221, 222], polymeric and metal nanoparticles [211, 214, 217] have been loaded in hydrogels/contact lenses to design extended-release composite systems with varying degree of success. Besides contact lenses, other composite systems including implants, fibers or in situ gels were also used to load nanoparticles [218, 223].…”

Section: Nanoparticles For Drug Delivery To the Anterior Segmentmentioning

confidence: 99%

“…Besides contact lenses, other composite systems including implants, fibers or in situ gels were also used to load nanoparticles [218, 223]. Drugs including lidocaine [210], ciprofloxacin [219], levofloxacin [220], CsA [221, 222], timolol [213, 217], silver [224], meloxicam [225], dexamethasone [226–228], loteprednol etabonate [214], hydrocortisone butyrate [223], and resina draconis [218] have been loaded into the nanoparticles to be delivered through the composite systems. Four different methods have been used to prepare nanoparticle-laden therapeutic contact lenses.…”

Section: Nanoparticles For Drug Delivery To the Anterior Segmentmentioning

confidence: 99%

Nanoparticles for drug delivery to the anterior segment of the eye

Janagam

Lowe

2017

Advanced Drug Delivery Reviews

279

165

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Commercially available ocular drug delivery systems are effective but less efficacious to manage diseases/disorders of the anterior segment of the eye. Recent advances in nanotechnology and molecular biology offer a great opportunity for efficacious ocular drug delivery for the treatments of anterior segment diseases/disorders. Nanoparticles have been designed for preparing eye drops or injectable solutions to surmount ocular obstacles faced after administration. Better drug pharmacokinetics, pharmacodynamics, non-specific toxicity, immunogenicity, and biorecognition can be achieved to improve drug efficacy when drugs are loaded in the nanoparticles. Despite the fact that a number of review articles have been published at various points in the past regarding nanoparticles for drug delivery, there is not a review yet focusing on the development of nanoparticles for ocular drug delivery to the anterior segment of the eye. This review fills in the gap and summarizes the development of nanoparticles as drug carriers for improving the penetration and bioavailability of drugs to the anterior segment of the eye.

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“…Other objective of this type of coatings is to avoid the adsorption of microorganisms and proteins from the ocular tear fluid which is one of the main causes of eye infections among the contact lenses users. The coatings applied to SCLs are, essentially, based on polyelectrolyte multilayers obtained using layer-by-layer (LbL) deposition [12], on the adsorption/grafting of specific molecules [13,14], and on the immobilization of liposomes at the surface of the lens [15]. The LbL technique has been attracting great attention because it allows a high level of control over the composition and the physical properties of the coating material.…”

Section: Introductionmentioning

confidence: 99%