ANTIBACTERIAL ACTIVITY OF COPPER OXIDE NANOPARTICLES AGAINST METHICILLIN RESISTANT Staphylococcus aureus (MRSA).

Raheem, Haider Qassim; Al-Ghazali, Linda H; Al-Marzook, Farah A.

doi:10.25258/ijpqa.10.3.5

Cited by 5 publications

(4 citation statements)

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“…As illustrated in Fig. 2a, CSBC exhibited typical broad and gradual amorphous carbon diffraction peaks at 2θ = 15-30°; [19] the X-ray diffraction peaks appearing at 28.2°, 30 X-ray photoelectron spectroscopy (XPS) was employed to further evaluate the valence states of the Cu 4 O 3 /CSBC composite. The presence of elemental Cu signal peaks con rmed the deposition of elemental Cu on the biochar surface, as illustrated in the XPS spectra (Fig.…”

Section: Preparation and Characterization Of The Cu 4 O 3 /Biochar Co...mentioning

confidence: 99%

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Green solid-state synthesis of Cu4O3/biochar composites with high antimicrobial activity

Sun,

Yang,

Shen

et al. 2024

Preprint

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Infectious diseases caused by pathogenic microorganisms have inflicted significant calamities upon human society. The Cu4O3/biochar composites with high efficacy of antimicrobial properties are developed for the first time via a green solid synthesis strategy of ball milling and sintering processes in this work. The mechanistic investigation revealed that the biochar, e.g. corn stover, plays multiple physiochemical roles as a support carrier, dispersant, and reducing agent, regulating elegantly the stoichiometric ratio of Cu2O and CuO. The potent antimicrobial activities of the Cu4O3/biochar composite were confirmed against E. coli, S. aureus, and methicillin-resistant Staphylococcus aureus MRSA through minimum inhibitory concentration (MIC) testing, exhibiting extremely low MIC values against the Gram-positive strains S. aureus and MRSA. Furthermore, the antibacterial mechanisms of the Cu4O3/biochar composite were studied through the experiments and quantum mechanical computations, showing the enhanced effects between the successive release of Cu(I)/Cu(II) ions and the generation of reactive oxygen species. This work reports the first solid-state symproportionation reactions of CuOx to prepare high-purity Cu4O3, stabilized by biochar with the advantages of simplicity, low cost, brevity, mild reaction conditions, and eco-friendliness. The Cu4O3/biochar composite can be applied as additives in anti-bacterial materials to protect against harmful microbial infections including superbugs.

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Section: Preparation and Characterization Of The Cu 4 O 3 /Biochar Co...mentioning

confidence: 99%

“…Cu NPs (particle size: 50 nm) 1.875-3.75 [29] CuO NPs (particle size: 40 nm) 75-150 [30] Cu 2 O@ZrP hybrid nanosheet 200…”

Section: Antibacterial Propertymentioning

confidence: 99%

Green solid-state synthesis of Cu4O3/biochar composites with high antimicrobial activity

Sun,

Yang,

Shen

et al. 2024

Preprint

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“…They have been found on the coastal beach and river water in many regions of the world [7,8]. Antibacterial resistance is a challenge for S. aureus, as well as many other bacterial disorders, particularly antibiotic-resistant diseases, which have received significant attention recently [9]. Antibacterial active agents are being researched as a workable solution.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Spherical Copper Oxide Nanoparticles by Chemical Precipitation Method and Investigation of Their Photocatalytic and Antibacterial Activities

Nahar

Chaity

Gafur

et al. 2023

Journal of Nanomaterials

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Methylene blue (MB) dye and Staphylococcus aureus (S. aureus) bacteria in wastewater are the two significant problems currently. Researchers have been looking for materials that can combat these two problems at the same time. In the present study, we describe the synthesis of spherical copper oxide (CuO) nanoparticles (NPs) by the chemical precipitation method and evaluate their photocatalytic performance against MB dye and antibacterial efficacy against S. aureus. CuO NPs were produced using copper acetate monohydrate (Cu(CH3COO)2·H2O) as the precursor and sodium hydroxide (NaOH) as the reducing agent. Synthesized CuO NPs were characterized using a combination of techniques, including ultraviolet–visible spectroscopy, X-ray diffraction, transmission electron microscopy, selected area electron diffraction, Fourier transform infrared, and energy-dispersive X-ray diffraction analysis. All the analyses indicated that monoclinic CuO NPs were formed with a spherical shape and an average particle size of 6.2 nm. Photocatalytic experiments indicated that 55.5% of a 10 ppm MB dye solution was degraded by the prepared nano-CuO photocatalyst only after 60 min. Additionally, synthesized CuO NPs demonstrated, to some extent, the zone of inhibition on the S. aureus bacterium’s cell wall. It is inspiring that CuO NPs can be used to solve two problems of MB dye contamination and S. aureus bacterial infection simultaneously.

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“…[6][7][8][9] Among a wide variety of nanomaterials, metal oxide nanomaterials have served as important antibacterial agents against bacteria, fungus, viruses, and parasites, owing to their small size and high surface volume ratio, which allows to closely interact with bacterial membranes, leading to the formation of reactive oxygen species, lipid peroxidation and bactericidal consequently. [10][11][12][13] With superior chemical and physical properties, nanoparticles of CuO have shown antimicrobial effect against many species, [14,15] including Escherichia coli (E. coli), [16,17] Bacillus subtilis(B. subtilis), [18,19] Pseudomonas aeruginosa Aeruginosa (P. aeruginosa), [20] and Staphylococcus aureus (S. aureus), [21] and antibiotic-resistant microorganisms such as methicillin-resistant Staphylococcus aureus (MRSA), [22,23] which makes copper-based nanoparticles promising for the development of new antimicrobial agents to control drug-resistant bacterial pathogens.…”

Section: Introducementioning

confidence: 99%

PPy and CQDs‐doped novel CuO nanocomposites for enhanced antibacterial activity against drug‐resistant bacteria.**

et al. 2022

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With the development of modern medicine, the use of antibiotics is more and more extensive, drug‐resistant bacteria appear, the antibacterial effect of traditional antibiotics becomes weak, and new drugs are urgently needed to solve the problem of bacterial resistance. In this paper, carbon quantum dots (CQDs) were synthesized by hydrothermal method, polypyrrole (PPy) was synthesized by chemical polymerization, and PPy/CuO/CQD ternary composite was formed by composite with copper oxide. FT‐IR and XPS were used to characterize and analyze the chemical composition of PPy/CuO/CQDs. XRD results confirmed the purity of CuO, and SEM and TEM images showed that the addition of CQDs made CuO nanorods distributed evenly on PPy nanosheets. In vitro antibacterial experiments showed that PPy/CuO/CQDs nanocomposites had high antibacterial performance against Escherichia coli, Staphylococcus aureus, and methicillin‐resistant Staphylococcus aureus. When the concentration of PPy/CuO/CQDs nanocomposites was 0.5 mg/mL, the growth inhibition of the three kinds of bacteria could reach 99.99 %, and the antibacterial effect was realized by the synergistic effect of the three components. It provides a good idea for the development of antibacterial drugs in medicine. In addition, in vitro cell proliferation experiments showed that PPy/CuO/CQDs complex had an anti‐tumor effect on HepG2 cells.

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ANTIBACTERIAL ACTIVITY OF COPPER OXIDE NANOPARTICLES AGAINST METHICILLIN RESISTANT Staphylococcus aureus (MRSA).

Cited by 5 publications

References 0 publications

Green solid-state synthesis of Cu4O3/biochar composites with high antimicrobial activity

Green solid-state synthesis of Cu4O3/biochar composites with high antimicrobial activity

Synthesis of Spherical Copper Oxide Nanoparticles by Chemical Precipitation Method and Investigation of Their Photocatalytic and Antibacterial Activities

PPy and CQDs‐doped novel CuO nanocomposites for enhanced antibacterial activity against drug‐resistant bacteria.**

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