Antibacterial activity of extracts and neolignans from Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck

Pessini, Greisiele Lorena; Filho, Benedito Prado Dias; Nakamura, Celso Vataru; Cortez, Diógenes Aparı́cio Garcia

doi:10.1590/s0074-02762003000800025

Cited by 68 publications

(58 citation statements)

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“…Its phytochemistry has been object of extensive reviews. 10,11) With regard to the ethnopharmacological information, while the pungent and aromatic fruits of some species of Piper are used as spices, most of them find wide application in traditional systems of medicine 10,11) as insecticides, 7,[12][13][14] antivirals, 15,16) antimicrobials [17][18][19][20][21] and particularly antifungals. [22][23][24][25][26][27][28] These biological properties have been attributed to the presence of lignans and/or amides, such as alkyl or olefinic isobutylamides, 7,23,29) flavonoids, kawa-lactones, butenolides and cyclohexane epoxides, among others.…”

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confidence: 99%

Evaluation of Antifungal Activity of Piper solmsianum C. DC. var. solmsianum (Piperaceae)

Campos

Filho

Silva

et al. 2005

Biological & Pharmaceutical Bulletin

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The incidence of opportunistic fungal infections in immunocompromised patients, such as those undergoing treatment with immunosuppressive drugs, intensive chemotherapy, AIDS patients and neonates, is increasing at an alarming rate. 1,2) These mycoses are very difficult to eradicate, and present an enormous challenge for healthcare providers. 3,4) The diversity of plant species in Brazil, together with their known ethnopharmacological uses, creates enormous potential for finding new structures with antifungal properties. 5,6) The Piperaceae is a vast family of plants, which has been extensively used for medicinal purposes.7) It comprises about 10 genus and approximately 2000 species, most of them herbaceous, 8) which are found mainly in tropical areas. Piper and Peperomia, the two greatest genera of the family, are well-represented in the Brazilian flora. 9)Within the Piperaceae family, the genus Piper has over 700 species, distributed throughout the tropical and subtropical regions of the world. Its phytochemistry has been object of extensive reviews. 10,11) With regard to the ethnopharmacological information, while the pungent and aromatic fruits of some species of Piper are used as spices, most of them find wide application in traditional systems of medicine 10,11) as insecticides, 7,[12][13][14] antivirals, 15,16) antimicrobials [17][18][19][20][21] and particularly antifungals. [22][23][24][25][26][27][28] These biological properties have been attributed to the presence of lignans and/or amides, such as alkyl or olefinic isobutylamides, 7,23,29) flavonoids, kawa-lactones, butenolides and cyclohexane epoxides, among others. 10)Among the different species of Piper growing in Brazil, Piper solmsianum (syn. P. leucathum or P. santosanum) known popularly as "pariparoba", is a shrub that measures 1-3 m. There are few reports on the chemical or biological studies of this plant. In contrast, phytochemical studies indicated the presence of aliphatic hydrocarbons, monoterpenes, sesquiterpenes, arylpropanoids and neolignans. [30][31][32] Recently, we have demonstrated that the fractions and some pure compounds (lignans) from the leaves of this plant exhibit significant activity against Gram-positive bacteria. 33)The current study extends our previous work on the biological properties of P. solmsianum and describes the in vitro antifungal activity of extracts, fractions and pure compounds against a panel of opportunistic pathogenic fungi using the agar dilution method. MATERIALS AND METHODS Plant MaterialPiper solmsianum C. DC. var. solmsianum (Piperaceae) was collected in May, 2001, in Ponta Grossa, State of Paraná, Brazil, and identified by Dr. Elsie Franklin Guimarães (Rio de Janeiro Botanic Museum Herbarium). A voucher specimen was deposited in the same herbarium under the number RB 368597.Phytochemical Analyses Air-dried leaves (1.36 kg) of P. solmsianum var. solmsianum were cut into small pieces and macerated at room temperature for one week in methanol. After filtration, the solvent was removed by rotary evaporat...

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confidence: 99%

Evaluation of Antifungal Activity of Piper solmsianum C. DC. var. solmsianum (Piperaceae)

Campos

Filho

Silva

et al. 2005

Biological & Pharmaceutical Bulletin

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“…The antiviral potential of Piper regnelli was (Pessini et al, 2003), antifungal (Koroishi et al, 2008), and antileishmanial (Vendrametto et al, 2010) effects, it was not active against both viruses.…”

Section: Resultsmentioning

confidence: 97%

“…The antimicrobial activity of eupomatenoid-5 isolated from Piper regnelli (Pessini et al, 2003) was not observed against either BHV-1 or poliovirus, indicating that this compound has no antiviral activity.…”

Section: Resultsmentioning

confidence: 98%

“…A phytochemical study of Piper regnelli isolated phenylpropanoids and dihydrobenzofuran neolignans. Previous studies indicated the presence of (+)-conocarpan as a major compound, in addition to eupomatenoid-6, eupomatenoid-5, and eupomatenoid-3 (Koroishi et al, 2008;Luize et al, 2006;Pessini et al, 2003).…”

Section: Resultsmentioning

confidence: 99%

“…Its leaves and roots are used in folk medicine in the form of crude extracts, infusions, and poultices for the treatment of wounds, swelling, and skin irritations (Yuncker, 1972). The extract and eupomatenoid-5, the neolignan isolated from the leaves of P. regnelli, have antimicrobial activity, including antibacterial (Pessini et al, 2003), antifungal (Koroishi et al, 2008), antileishmanial (Vendrametto et al, 2010), and trypanocidal (Luize et al, 2005) effects.…”

Section: Introductionmentioning

confidence: 99%

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Antiviral activity of fractions from leaves of Piper regnelli var. pallescens

Bertól¹,

Santos²,

Rodrigues³

et al. 2012

Rev. bras. farmacogn.

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This study investigated the antiviral potential of fractions and eupomatenoid-5 obtained from Piper regnelli (Miq.) C. DC., Piperaceae, leaves against bovine herpesvirus-1 (BHV-1) and poliovirus. VERO cell monolayers in 96-well cell culture plates were infected with BHV-1 or poliovirus and incubated in the presence and absence of samples for 48 h. The cells were then fixed and stained with sulforhodamine B, and the virus-induced cytopathic effect was measured in a 96-well plate reader at 530 nm. Cytotoxicity was assessed by incubating the cell monolayers with samples for 72 h. The hexane, chloroform, chloroform/ethyl acetate (19:1), and chloroform/ethyl acetate (9:1) fractions showed activity against BHV-1. The chloroform, chloroform/ethyl acetate (19:1), chloroform/ethyl acetate (9:1), chloroform/ethyl acetate (1:1), and ethyl acetate fractions were active against poliovirus. The chloroform/ethyl acetate (9:1) fraction presented the best selectivity index for both viruses. The present study reports the antiviral activity of the extract and fractions of P. regnelli leaves.

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Natural Products as Antimicrobial Agents – an Update

Saleem

2014

Novel Antimicrobial Agents and Strategies

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Antibacterial activity of extracts and neolignans from Piper regnellii (Miq.) C. DC. var. pallescens (C. DC.) Yunck

Cited by 68 publications

References 9 publications

Evaluation of Antifungal Activity of Piper solmsianum C. DC. var. solmsianum (Piperaceae)

Evaluation of Antifungal Activity of Piper solmsianum C. DC. var. solmsianum (Piperaceae)

Antiviral activity of fractions from leaves of Piper regnelli var. pallescens

Natural Products as Antimicrobial Agents – an Update

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