Antiviral activity of fractions from leaves of Piper regnelli var. pallescens

Bertól, Jéssica Wildgrube; Santos, Patrícia Regina dos; Rodrigues, Juliana; Cortez, Diógenes Aparı́cio Garcia; Filho, Benedito Prado Dias; Nakamura, Celso Vataru; Ueda-Nakamura, Tânia

doi:10.1590/s0102-695x2012005000110

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…As a result of the study, P. regnelli subsp. pallescens has been reported to show the best effect in ethyl acetate extract [85]. In a study conducted in Argentina, the effect of extracts obtained from species belonging to different genera on Poliovirus was investigated.…”

Section: Poliovirus (Genus: Enterovirus)mentioning

confidence: 99%

A Review on Antiviral Plants Effective Against Different Virus Types

Mohammed¹,

Uysal²,

Sevindik³

2023

pps

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The treatment of microbial infections has proven challenging for humans in recent years. Synthetic medications, such as antimicrobial agents, are used for treating these infections. Antimicrobials derived from natural sources have gained popularity as an alternative to manufactured medications due to their lack of adverse effects. Plants, which play a significant role in this setting, have historically served as a reliable natural defence against several pathogens. In this study, studies on plants used against viral diseases are mentioned. Studies on viruses that cause disease have been compiled in the literature. According to the findings, it has been reported in the literature that many different plant species are effective against herpes simplex virus (HSV-1, HSV-2), human immunodeficiency virus (HIV), influenza virus (A, B) and parainfluenza, Poliovirus, Astrovirus, Parvovirus, Sindbis virus (SINV), Feline calicivirus (FCV), Rhinovirus, Echovirus, Rotavirus, Bovine alphaherpesvirus 1 (BoHV-1), Reovirus, Vaccinia virus (VACV), Cardiovirus A (Encephalomyocarditis virus; EMCV), Coxsackie virus, Semliki forest, Measles virus, Newcastle disease virus (NDV), Coronavirus, Adenovirus (ADV-3, ADV-5, ADV-8, ADV -11), Canine distemper virus (CDV), Lumpy skin disease virus (LSDV), Hepatitis A, B, C virus and Enterovirus. To combat viruses, plants can be considered a potentially invaluable natural resource.

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Section: Poliovirus (Genus: Enterovirus)mentioning

confidence: 99%

A Review on Antiviral Plants Effective Against Different Virus Types

Mohammed¹,

Uysal²,

Sevindik³

2023

pps

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“…Solanaceae Substâncias isoladas (fisalinas) de extratos de toda planta, partes aéreas Antimalárica / Imunomodulatória / Antiinflamatória / Antiviral [65][66][67] Poliovirus-I, Herpes simplex virus-I, Measles virus e HIV-I Piper spp. Piperaceae Folha Antimalárica / Antiinflamatória/Antiviral [52,68,69] BHV-1 e Poliovirus (Piper regnelli) Calophyllum spp. Calophyllaceae Substância isolada de extratos orgânicos da casca do caule Antimalárica / Antiinflamatória / Antiviral [70] Vírus da Imunodeficiência Humana (HIV), HCoV…”

Section: Physalis Angulataunclassified

Do quinino aos antimaláricos sintéticos: o conhecimento das plantas medicinais como estratégia potencial na terapia da CoVID-19

Bizarri

Rezende

Mattos

et al. 2021

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CoVID-19 é uma doença infecciosa causada pelo vírus SARS-CoV-2, que apresenta uma sintomatologia complexa, atingindo vários órgãos e sistemas do organismo humano. Estudos com plantas medicinais indicam as diversas atividades farmacológicas que uma mesma espécie vegetal pode apresentar. Plantas com atividade antimalárica têm sido alvo de estudos para o tratamento da CoVID-19, através de suas ações combatendo diretamente o vírus, como na redução ou eliminação dos sintomas. O objetivo deste estudo foi verificar, na literatura científica, o uso das plantas medicinais com atividade antimalárica como potencial estratégia na terapia da CoVID-19. Foram realizadas pesquisa, sistematização de artigos e revisões da literatura de plantas com atividade antimalárica, antiviral, anti-inflamatória e imunomoduladora publicados nos últimos 20 anos. Listou-se 27 espécies de plantas importantes com atividade antimalárica. Dentre essas, plantas dos gêneros Cinchona e Artemisia destacaram-se por apresentarem atividades antimalárica e antiviral, tendo como principais constituintes majoritários, responsáveis por estas atividades, a quinina e a artemisinina, respectivamente. Foi possível destacar a importância e urgência da pesquisa e do desenvolvimento de medicamentos provenientes da diversidade vegetal, considerando a multiplicidade de ações farmacológicas que as plantas selecionadas apresentam, podendo ser potencialmente aplicáveis na terapia contra a CoVID-19.

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“…A complex of natural products is synthesized from the secondary metabolism of Piper, consisting in a mixture of bioactive organic compounds such as phenols, terpenes, esters, alcohols, among others (KUMAR et al, 2018). Several studies recognized these compounds for their biological activity as bactericides and fungicides (COSTA et al, 2016;PASCoLI et al, 2018;FERNANDEZ et al, 2019), antiprotozoans (GARCIA et al, 2013;VILLAMIZAR et al, 2017), antitumoral (LoNGAto et al, 2011) and antivirals (BERtoL et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Activity of Piperaceae extracts and fractions in the control of Phytomonas serpens

et al. 2020

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Protozoa of the genus Phytomonas are harmful parasites to several agricultural crops of economic importance. Due to their recognized biological activity, crude extracts of Piper aduncum, P. crassinervium, P. hispidum, and P. amalago leaves, were tested using the microdilution plate technique to assess the antiparasitic potential against Phytomonas serpens. Results showed that the ethanolic crude extract of P. crassinervium and P. amalago presented the best inhibitory concentration for 50% of the cells (IC50), 16.5 µg mL-1 in chloroform phase, and 18 µg mL-1 in aqueous phase, respectively, after 48 h treatment. Cytotoxicity analyses were performed using the colorimetric method of sulforhodamine-B in LLCMK2 mammalian cells. The chloroform phase of P. crassinervium was subjected to the fractionation process, in which the ethyl acetate and dichloromethane fractions obtained better IC50 values. Scanning electron microscopy (SEM) images showed alterations in the cell membrane of the treated parasites. The data obtained indicate a potential antiparasitic effect of the Piper species analyzed against P. serpens, being considered promising candidates for formulations of bioproducts to control the parasite.

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Antiviral activity of fractions from leaves of Piper regnelli var. pallescens

Cited by 4 publications

References 25 publications

A Review on Antiviral Plants Effective Against Different Virus Types

A Review on Antiviral Plants Effective Against Different Virus Types

Do quinino aos antimaláricos sintéticos: o conhecimento das plantas medicinais como estratégia potencial na terapia da CoVID-19

Activity of Piperaceae extracts and fractions in the control of Phytomonas serpens

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