Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria

Schempp, Christoph M.; Pelz, Klaus; Wittmer, Annette; Schöpf, Erwin; Simon, Jan C.

doi:10.1016/s0140-6736(99)00214-7

Cited by 233 publications

(145 citation statements)

References 3 publications

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“…However, the mechanism of hyperforin-induced effects was not sufficiently understood. Hyperforin has long been known to possess antibacterial activity (37,38) and to inhibit the growth of multi-resistant strains of Staphylococcus aureus (39). Although its antibacterial properties may contribute to the positive effects in treatment of AD, our data may give an additional, quite plausible explanation for a dermatological use of hyperforin that deserves further investigation.…”

Section: Differentiation and Proliferation Defects In Skin Patho-mentioning

confidence: 65%

Specific TRPC6 Channel Activation, a Novel Approach to Stimulate Keratinocyte Differentiation

Müller

Essin

Hill

et al. 2008

Journal of Biological Chemistry

102

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Section: Differentiation and Proliferation Defects In Skin Patho-mentioning

confidence: 65%

Specific TRPC6 Channel Activation, a Novel Approach to Stimulate Keratinocyte Differentiation

Müller

Essin

Hill

et al. 2008

Journal of Biological Chemistry

102

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“…40 HF exhibited an excellent effect against methicillin-resistant strains of S. aureus and Helicobacter pylori.…”

Section: Antimicrobial Effectsmentioning

confidence: 99%

Hyperforin, a new lead compound against the progression of cancer and leukemia?

Quiney

Billard

Salanoubat³

et al. 2006

Leukemia

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“…5 Furthermore, HF exerts antibacterial activity against multiresistant Staphylococcus aureus and Gram-positive bacteria. 6 HF displays antioxidant properties, impairs the production of superoxide from activated neutrophils 7 and inhibits various cytochrome P450 isoforms, 8 a chronic exposure leading to inhibition of CYP3A4 activity in vivo. 9 HF acts as a dual inhibitor of 5-lipooxygenase and of cyclooxygenase 1 (COX-1), hence its interest in the treatment of inflammatory and allergic diseases connected to eicosanoids.…”

Section: Introductionmentioning

confidence: 99%

Pro-apoptotic properties of hyperforin in leukemic cells from patients with B-cell chronic lymphocytic leukemia

Quiney

Billard

et al. 2006

Leukemia

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The effects of the hyperforin (HF), a natural phloroglucinol purified from Hypericum perforatum, were investigated ex vivo on leukemic cells from patients with B-cell chronic lymphocytic leukemia (B-CLL). HF was found to promote apoptosis of B-CLL cells, as shown by time-and dose-dependent stimulation of phosphatidylserine externalization and DNA fragmentation, by disruption of the mitochondrial transmembrane potential, caspase-3 activation and cleavage of the caspase substrate PARP-1. Moreover, HF-induced downregulation of Bcl-2 and Mcl-1, two antiapoptotic proteins that control mitochondrial permeability. HF also downregulated two proteins which are overexpressed by B-CLL patients' cells, the cell cycle inhibitor p27 kip1 through caspase-dependent cleavage into a p23 form, and the nitric oxid (NO) synthase of type 2 (inducible NO synthase). This latter was accompanied by reduction in the production of NO known to be antiapoptotic in B-CLL cells. Preventing effects of the general caspase inhibitor z-VAD-fmk indicated that HF-promoted apoptosis of B-CLL cells was mostly caspase dependent. Furthermore, normal B lymphocytes purified from healthy donors appeared less sensitive to HF-induced apoptosis than B-CLL cells. These results indicate that HF may be of interest in the development of new therapies for B-CLL based on the induction of apoptosis and combination with cell cycle-dependent antitumor drugs.

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Antibacterial activity of hyperforin from St John's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria

Cited by 233 publications

References 3 publications

Specific TRPC6 Channel Activation, a Novel Approach to Stimulate Keratinocyte Differentiation

Specific TRPC6 Channel Activation, a Novel Approach to Stimulate Keratinocyte Differentiation

Hyperforin, a new lead compound against the progression of cancer and leukemia?

Pro-apoptotic properties of hyperforin in leukemic cells from patients with B-cell chronic lymphocytic leukemia

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