Antibacterial Activity of <i>Hydrastis canadensis</i> Extract and its Major Isolated Alkaloids

Scazzocchio, F; Cometa, Maria Francesca; Tomassini, Lamberto; Palmery, Maura

doi:10.1055/s-2001-16493

Cited by 129 publications

(83 citation statements)

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“…The popular herbal medicine goldenseal (Hydrastis canadensis) is known in traditional medicine for its anti-inflammatory and antimicrobial properties and is found to produce an abundance of alkaloid compounds with a potential for bioactivity (279). A recent investigation found that extracts of goldenseal were able to inhibit the Agr signaling pathway of S. aureus, as determined by luciferase reporters that indicate quorum-sensing activity, and were shown to reduce alpha-toxin production (280).…”

Section: Natural-product Qs Inhibitorsmentioning

confidence: 99%

Exploiting Quorum Sensing To Confuse Bacterial Pathogens

LaSarre

Federle

2013

Microbiol Mol Biol Rev

689

556

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SUMMARY Cell-cell communication, or quorum sensing, is a widespread phenomenon in bacteria that is used to coordinate gene expression among local populations. Its use by bacterial pathogens to regulate genes that promote invasion, defense, and spread has been particularly well documented. With the ongoing emergence of antibiotic-resistant pathogens, there is a current need for development of alternative therapeutic strategies. An antivirulence approach by which quorum sensing is impeded has caught on as a viable means to manipulate bacterial processes, especially pathogenic traits that are harmful to human and animal health and agricultural productivity. The identification and development of chemical compounds and enzymes that facilitate quorum-sensing inhibition (QSI) by targeting signaling molecules, signal biogenesis, or signal detection are reviewed here. Overall, the evidence suggests that QSI therapy may be efficacious against some, but not necessarily all, bacterial pathogens, and several failures and ongoing concerns that may steer future studies in productive directions are discussed. Nevertheless, various QSI successes have rightfully perpetuated excitement surrounding new potential therapies, and this review highlights promising QSI leads in disrupting pathogenesis in both plants and animals.

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Section: Natural-product Qs Inhibitorsmentioning

confidence: 99%

Exploiting Quorum Sensing To Confuse Bacterial Pathogens

LaSarre

Federle

2013

Microbiol Mol Biol Rev

689

556

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“…The increasing failure of chemotherapeutics and antibiotic resistance exhibited by pathogenic microbial infectious agents have lead to the screening of several medicinal plants for their potential antimicrobial activity (1,2,3,4). Terminafia bellerica belongs to the family "Combretaceae".…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity ofTerminalia bellerica

Elizabeth¹

2005

Indian J Clin Biochem

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The antimicrobial activity of crude and methanol extract of Terminalia bel/enca dry fruit was tested by disc diffusion method, against 9 human microbial pathogens. Crude aqueous extract of dry fruit at 4 mg concentration showed zone of inhibition ranging from 15.5-28.0 mm. S. aureus was found to be highly susceptible forming highest zone of inhibition, suggesting that T. bellerica was strongly inhibitory towards this organism. These pathogens were highly sensitive to the methanol extract forming 14.0 to 30.0 mm zone of inhibition suggesting that the methanol extract of T. bel/erica was more effective than crude extract against most of the microbes tested except E. coil (enteropathogen) and P. aeruginosa. The minimal inhibitory concentrations (MICs) of crude and methanol extracts were determined by broth dilution technique which ranged from 300 to >2400 pg/ml and 250 pg to >2000 pg/ml respectively, indicating that T. bellenca was highly effective against S. aureus with lower MIC values. There were some biochemical alterations induced by 7-. bellenca. These results indicate that 7-. bellerica dry fruit possesses potential broad spectrum antimicrobial activity.

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“…8812, belongs to isoquinoline alkaloids, some of which exhibit antibacterial activity (for example, plant origin products such as berberine, canadaline, canadine, (+)-N-(methoxycarbonyl)-N-norboline). 16,17 Some of them show an activity toward S. aureus, which is analogous to JS-1. Iwasa et al 18 described antimicrobial, antimalarial, cytotoxic and anti-HIV activities of simple, natural and synthetic isoquinoline and benzylisoquinoline alkaloids.…”

Section: Genotoxicitymentioning

confidence: 97%

A novel isoquinoline alkaloid, DD-carboxypeptidase inhibitor, with antibacterial activity isolated from Streptomyces sp. 8812. Part I: Taxonomy, fermentation, isolation and biological activities

2009

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A novel isoquinoline alkaloid of molecular formula C 10 H 9 NO 4 , labeled JS-1, was isolated from the culture broth of Streptomyces sp. 8812. It was purified by acetone protein precipitation from the culture supernatant, followed by anion exchange and C18 RP HPLC columns. JS-1 is an inhibitor of exocellular DD-carboxypeptidases/transpeptidases (DD-peptidases) 64-575 II from Saccharopolyspora erythraea 64-575 II, and R39 from Actinomadura R39. JS-1 exhibits activity against Gram-negative bacteria, such as Bordetella bronchiseptica, Stenotrophomonas maltophilia, Proteus vulgaris, P. mirabilis, Burkholderia cepacia and Acinetobacter baumanii, with MIC values 10-160 lg ml À1 , and against Gram-positive bacteria, such as Staphylococcus aureus, with MIC values 40-206 lg ml À1 .

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Antibacterial Activity of Hydrastis canadensis Extract and its Major Isolated Alkaloids

Cited by 129 publications

References 0 publications

Exploiting Quorum Sensing To Confuse Bacterial Pathogens

Exploiting Quorum Sensing To Confuse Bacterial Pathogens

Antimicrobial activity ofTerminalia bellerica

A novel isoquinoline alkaloid, DD-carboxypeptidase inhibitor, with antibacterial activity isolated from Streptomyces sp. 8812. Part I: Taxonomy, fermentation, isolation and biological activities

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