Antibacterial Activity ofSanguisorba officinalisagainstHelicobacter pylori

Abstract

In this study, a medicinal herbal plant, Sanguisorba officinalis, was examined and screened for anti-Helicobacter pylori (H. pylori) activity. Seventy percent ethanol was used for herbal extraction. For anti-H. pylori activity screening, inhibitory zone tests as an in vitro assay and in vivo study using a Mongolian gerbil (Meriones unguiculatus) model were performed. Also, the safety of herbal compounds was evaluated by animal study. As a result of inhibitory zone test, Sanguisorba officinalis extract demonstrated strong anti-H. pylori activities. Also, as results of in vivo animal studies, Sanguisorba officinalis extract demonstrated strong therapeutic effects against H. pylori infection according to the criteria of histological examination and rapid urease test. As results of the safety study, after 28 days treatment of the Sanguisorba officinalis extract, the animals were not detected any grossly and histological changes. These results demonstrate that it can be successfully cured against H. pylori infection and protected from H. pylori-induced pathology with Sanguisorba officinalis extract. It could be a promising candidate herb treatment for patients with gastric complaints including gastric ulcer caused by H. pylori.

In Vitro Antioxidant and Anti-Propionibacterium acnes Activities of Cold Water, Hot Water, and Methanol Extracts, and Their Respective Ethyl Acetate Fractions, from Sanguisorba officinalis L. Roots

“…It is unclear whether the anti- P. acnes compounds are rich in the roots but not in the aerial parts of S. officinalis L. Among the extracts and their respective EA fractions, the SOR ME and ME-EA showed the lowest MIC and MBC values against P. acnes . Furthermore, the SOR ME and ME-EA showed antimicrobial activity against numerous Gram-negative and -positive bacteria, which corresponds to earlier works [ 31 , 37 , 38 ]. It suggested that the SOR ME displayed a broad spectrum of antibacterial activity, whereas both the CWE and HWE displayed a narrow spectrum of antibacterial activity.…”

Comparison of the pharmacokinetic profiles of 13 phenolic acids and 6 triterpenes in normal and leukopenia rats after oral administration of Sanguisorba officinalis L. extract by LC‐MS/MS

“…For centuries, traditional Chinese medicine has been widely used in East Asia to treat diseases [6][7][8][9]. Notably, Diyv Shengbai Tablet, whose main component is the powder of Sanguisorba officinalis L., has been generally used to treat leukopenia in clinical practice [10][11][12][13][14]. Sanguisorba officinalis L. (the dried root of Sanguisorba, Rosaceae) is a traditional medicinal herb that is widely distributed in Europe and Asia.…”

“…For centuries, traditional Chinese medicine has been widely used in East Asia to treat diseases [6–9]. Notably, Diyv Shengbai Tablet, whose main component is the powder of Sanguisorba officinalis L., has been generally used to treat leukopenia in clinical practice [10–14].…”

Simultaneous Determination and Pharmacokinetics Study of Six Triterpenes in Rat Plasma by UHPLC-MS/MS after Oral Administration of Sanguisorba officinalis L. Extract

“…According to the Chinese pharmacopoeia, it plays a major role in the treatment of hematochezia, bleeding hemorrhoids, bloody flux, metrorrhagia and metrostaxis, bleeding wounds, burns and scalds, and swollen carbuncles [ 3 ]. Besides, in vivo and in vitro studies have illustrated that plants from the S. officinalis present a wide range of pharmacological properties, including hemostatic, antioxidant [ 4 ], anti-inflammatory [ 5 ], antiviral [ 6 ], antibacterial [ 7 , 8 ], anti-tumor [ 9 ], neuroprotective and hypoglycemic activities [ 10 ]. Simultaneously, in Chinese medical practice, many drugs (e.g., tablets and powders) that contain S. officinalis roots have been applied to treat leukopenia, hemorrhaging and burns [ 11 ].…”