In Vitro Antioxidant and Anti-Propionibacterium acnes Activities of Cold Water, Hot Water, and Methanol Extracts, and Their Respective Ethyl Acetate Fractions, from Sanguisorba officinalis L. Roots

Kim, Seong-Dae; Oh, Sung Ho; Noh, Han Byul; Ji, Seongmi; Lee, Song Hee; Koo, Jung Mo; Choi, Chang Won; Jhun, Hyun Pyo

doi:10.3390/molecules23113001

Cited by 43 publications

(35 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In turn, quercetin-O-glucuronide was the dominant compound in the flowers, leaves, and stalks, constituting 69%, 83%, and 85% of all flavonols, respectively, whereas taxifolin 7-O-β-d-glucopyranoside prevailed in the roots, constituting 91%. These observations have also been confirmed by Kim et al [1].…”

Section: Quantification Of Polyphenolic Compoundssupporting

confidence: 83%

“…The interest in alternative plants with a health-promoting potential has been growing in recent years not only in the pharmaceutical and cosmetic industries but also in the food industry where they are expected to contribute to the design of novel functional food. Therefore, it is believed that various morphological parts of Sanguisorba officinalis L. represent a good source of compounds exhibiting the aforementioned properties [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…S. officinalis L. (great burnet or burnet bloodwort) is a species belonging to the Rosaceae family. It grows wild in Asia and Europe (except for the northern regions [ 1 , 2 ]. This melliferous, perennial plant usually occurs on arid and semi-arid grasslands and blooms from June till September.…”

Section: Introductionmentioning

confidence: 99%

“…However, in folk medicine of both the Far East and Europe, S. officinalis L. was used as an herbal medicine in relieving inflammation, controlling external and internal bleeding, in the treatment of ulcers, burns, eczema, acne, as well as diarrhea [ 4 , 5 ]. In turn, the available experimental data prove a number of its biological properties, e.g., anti-inflammatory [ 3 ], anticancer [ 6 ], antiviral [ 7 ], antioxidant [ 1 ], prevention of the Alzheimer’s disease [ 3 ], and anti-wrinkle effects. [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Profile and Content of Phenolic Compounds in Leaves, Flowers, Roots, and Stalks of Sanguisorba officinalis L. Determined with the LC-DAD-ESI-QTOF-MS/MS Analysis and Their In Vitro Antioxidant, Antidiabetic, Antiproliferative Potency

et al. 2020

View full text Add to dashboard Cite

The aim of this study was to accurately determine the profile of polyphenols using the highly sensitive LC–DAD–ESI–QTOF–MS/MS technique and to determine in vitro antioxidant activity, the ability of inhibition of α-amylase, α-glucoamylase, and pancreatic lipase activity, and antiproliferative activity in leaves, flowers, roots, and stalks of medical plant Sanguisorba officinalis L. The results of the analysis of the morphological parts indicated the presence of 130 polyphenols, including 62 that were detected in S. officinalis L. for the first time. The prevailing group was tannins, with contents ranging from 66.4% of total polyphenols in the flowers to 43.3% in the stalks. The highest content of polyphenols was identified in the flowers and reached 14,444.97 mg/100 g d.b., while the lowest was noted in the stalks and reached 4606.33 mg/100 g d.b. In turn, the highest values of the antiradical and reducing capacities were determined in the leaves and reached 6.63 and 0.30 mmol TE/g d.b, respectively. In turn, a high ability to inhibit activities of α-amylase and α-glucoamylase was noted in the flowers, while a high ability to inhibit the activity of pancreatic lipase was demonstrated in the leaves of S. officinalis L. In addition, the leaves and the flowers showed the most effective antiproliferative properties in pancreatic ductal adenocarcinoma, colorectal adenocarcinoma, bladder cancer, and T-cell leukemia cells, whereas the weakest activity was noted in the stalks. Thus, the best dietetic material to be used when composing functional foods were the leaves and the flowers of S. officinalis L., while the roots and the stalks were equally valuable plant materials.

show abstract

Section: Quantification Of Polyphenolic Compoundssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Profile and Content of Phenolic Compounds in Leaves, Flowers, Roots, and Stalks of Sanguisorba officinalis L. Determined with the LC-DAD-ESI-QTOF-MS/MS Analysis and Their In Vitro Antioxidant, Antidiabetic, Antiproliferative Potency

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Thus, it is an indispensable component of the organism's machinery and has been used as potential drug target in this study. We have identified the potential inhibitor, quercetin, based on its herbal nature, structural similarity (homologous) with the known inhibitor of DHNS from Mycobacterium tuberculosis (compound: 1486C16 (3Z)‐6‐chloro‐3‐(4‐methyl‐2‐oxopentylidene)‐3,4‐dihydro‐2H‐1,4‐benzoxazin‐2‐one) which showed 98% inhibition at 125 μg/mL concentration, the antibacterial nature, which is well established . In order to determine the structure of Ef DHNS, we have amplified the gene of DHNS from the genomic DNA of E .…”

Section: Discussionmentioning

confidence: 99%

Identification and evaluation of quercetin as a potential inhibitor of naphthoate synthase from Enterococcus faecalis

Das

Batra

Gupta

et al. 2019

J of Molecular Recognition

View full text Add to dashboard Cite

Enterococcus faecalis is a gram-positive, rod-shape bacteria responsible for around 65% to 80% of all enterococcal nosocomial infections. It is multidrug resistant (MDR) bacterium resistant to most of the first-line antibiotics. Due to the emergence of MDR strains, there is an urgent need to find novel targets to develop new antibacterial drugs against E. faecalis. In this regard, we have identified naphthoate synthase(1,4-dihydroxy-2-naphthoyl-CoA synthase, EC: 4.1.3.36; DHNS) as an anti-E. faecalis target, as it is an essential enzyme for menaquinone (vitamin K 2 ) synthetic pathway in the bacterium. Thus, inhibiting naphtholate synthase may consequently inhibit the bacteria's growth. In this regard, we report here cloning, expression, purification, and preliminary structural studies of naphthoate synthase along with in silico modeling, molecular dynamic simulation of the model and docking studies of naphthoate synthase with quercetin, a plant alkaloid. Biochemical studies have indicated quercetin, a plant flavonoid as the potential lead compound to inhibit catalytic activity of EfDHNS. Quercetin binding has also been validated by spectrofluorimetric studies in order to confirm the bindings of the ligand compound with EfDHNS at ultralow concentrations. Reported studies may provide a base for structure-based drug development of antimicrobial compounds against E. faecalis.

show abstract

Effect of Sanguisorba minor on scopolamine-induced memory loss in rat: involvement of oxidative stress and acetylcholinesterase

et al. 2022

View full text Add to dashboard Cite

In Vitro Antioxidant and Anti-Propionibacterium acnes Activities of Cold Water, Hot Water, and Methanol Extracts, and Their Respective Ethyl Acetate Fractions, from Sanguisorba officinalis L. Roots

Cited by 43 publications

References 64 publications

Profile and Content of Phenolic Compounds in Leaves, Flowers, Roots, and Stalks of Sanguisorba officinalis L. Determined with the LC-DAD-ESI-QTOF-MS/MS Analysis and Their In Vitro Antioxidant, Antidiabetic, Antiproliferative Potency

Profile and Content of Phenolic Compounds in Leaves, Flowers, Roots, and Stalks of Sanguisorba officinalis L. Determined with the LC-DAD-ESI-QTOF-MS/MS Analysis and Their In Vitro Antioxidant, Antidiabetic, Antiproliferative Potency

Identification and evaluation of quercetin as a potential inhibitor of naphthoate synthase from Enterococcus faecalis

Effect of Sanguisorba minor on scopolamine-induced memory loss in rat: involvement of oxidative stress and acetylcholinesterase

Contact Info

Product

Resources

About