Antibacterial activity of In-doped ZnO nanoparticles

Danial, Enas N.; Hjiri, M.; Abdel-wahab, M. Sh.; Alonizan, N.; Mır, L. El; Aida, M.S.

doi:10.1016/j.inoche.2020.108281

Cited by 54 publications

(17 citation statements)

References 64 publications

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“…These results clearly demonstrate the high activity of CoZnO/MoS 2 -30 in the inhibition of bacterial and fungus growth, in particular, in comparison to ZnO-based nanocomposites reported recently in the literature. , Indeed, after 18 h of treatment, one can see that in comparison to the control, the number of bacterial and fungus colonies decreased markedly in the presence of CoZnO, and almost none remained with MoS 2 and CoZnO/MoS 2 -30 (Figure j).…”

Section: Resultsmentioning

confidence: 99%

Cobalt-Doped Zinc Oxide Nanoparticle–MoS₂ Nanosheet Composites as Broad-Spectrum Bactericidal Agents

Cheng

Wang

Fan

et al. 2021

ACS Appl. Nano Mater.

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The design and engineering of high-performance antimicrobial agents is critical for combating antibiotic resistance. In the present study, a rapid and broad-spectrum bactericidal agent is developed based on nanocomposites consisting of cobalt-doped zinc oxide (CoZnO) nanoparticles and MoS 2 nanosheets. The CoZnO/MoS 2 nanocomposites are prepared by a facile chemical precipitation method at controlled CoZnO and MoS 2 feeds. Scanning and transmission electron microscopic measurements show that CoZnO nanoparticles (ca. 10 nm in diameter) are clustered on the MoS 2 nanosheet surface, which facilitates the charge separation of the photo-generated electron−hole pairs, leading to enhanced photodynamic antimicrobial activity. Antibacterial assays in the dark show that the CoZnO/MoS 2 nanocomposite prepared at 30 μg of MoS 2 feed (CoZnO/MoS 2 -30) exhibits the best performance among a series of samples, with minimum inhibitory concentrations of 0.25, 0.8, and 1.8 mg mL −1 toward the Gram-negative bacterium Escherichia coli, Grampositive bacterium Staphylococcus aureus and fungus Aspergillus flavus, respectively. The antibacterial performance is markedly enhanced under photoirradiation, where 94.0% inactivation of E. coli is achieved with 20 μg mL −1 CoZnO/MoS 2 -30 nanocomposite under photoirradiation (15 W, 360 nm) for 5 min. The high antibacterial activity can be ascribed to peroxidase-like photocatalytic activity that is conducive to the generation of reactive oxygen species, as evidenced in transmission electron microscopy, electron spin resonance, and intracellular glutathione oxidation measurements. The results of the present study highlight the significance of CoZnO/MoS 2 nanocomposites as potent photodynamic antibacterial agents.

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Section: Resultsmentioning

confidence: 99%

Cobalt-Doped Zinc Oxide Nanoparticle–MoS₂ Nanosheet Composites as Broad-Spectrum Bactericidal Agents

Cheng

Wang

Fan

et al. 2021

ACS Appl. Nano Mater.

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“…The sol-gel technique was used to synthesize HA with a Ca/P stoichiometric ratio of 1.67. To get the reaction performed [45][46][47], a combination of water and ethanol (1:12 by volume) was poured into the reaction flask, which contained around 50 mmol of calcium nitrate tetrahydrate (CNTH). Slow addition of (14.5 M) ammonia solution was used to keep the pH of the solution in the range of 10-12.…”

Section: Preparation Of N-hamentioning

confidence: 99%

Novel fabrication of marizomib-loaded chitosan-coated hydroxyapatite nanocarriers as a promising system for effective treatment of ovarian cancer

Xu¹,

Liao²,

Chen³

et al. 2022

Mater. Res. Express

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Cancer therapy might benefit greatly from nanotechnology. These nano-drug delivery systems (NDDS) have been established to improve the therapeutic benefits of anticancer medications by enhancing their bioavailability, degradation, and biocompatibility. One of the most promising NDDS for cancer therapy is high-performance hydroxyapatite (HA) nanoparticles, which have many advantages. The metabolite marizomib inhibits tumour cell growth and progression, which functions as a biochemical inhibitor in many malignancies. However, this substance's low bioavailability is the most significant problem with its use. In this work, a pH-sensitive biopolymer was employed to encapsulate HA nanoparticles with chitosan to increase marizomib's (MARI) efficacy and bioavailability. The sol-gel process was used to fabricate HA nanoparticles for this purpose. It was then coated with chitosan before encasing the marizomib drug in the nanocarrier, which was done under controlled circumstances. The newly fabricated nanoparticles effectively kill ovarian A2780 cancer cells and induce apoptosis. The morphological examination of the cancer cells was examined by AO/EB and DAPI staining methods. Further, the cell uptake was measured by the flow cytometry methods, and the result shows the nanoparticles were effectively uptake the cancer cells under different incubation times. In principle, nanoparticles have great potential for future pre-clinical applications in treating ovarian cancer cells and suppressing other types of tumours.

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“…ZnO nanoparticles were synthesized by a previously reported sol-gel method [37,38]. 0.1 M zinc acetate and 0.1 M oxalic acid mixtures (Zn (CH3CO2)2 / C2H2O4) were prepared with gentle stirring in ethanol for 30 min at 60 ± 5 °C and 50 ± 5 °C respectively.…”

Section: Synthesis Of Zno Nanoparticlesmentioning

confidence: 99%

“…They observed major diffraction peaks at 31.73, 34.39, 36.24, 47.51, 56.52, 62.88, 72.54 and 76.89 which assigned as (1 0 0), (0 0 2), (1 0 1), (1 0 2), (1 1 0), (1 0 3), (1 1 2), (2 0 1) and (2 0 2) planes respectively. The crystalline size of the nanoparticles were calculated using Hall-Williamson method[38]. The average crystallite size of the synthesized ZnO nanoparticles were 10 ± 1.8 nm.…”

mentioning

confidence: 99%

High flux polysulfone braided hollow fiber membrane for wastewater treatment role of zinc oxide as hydrophilic enhancer

Peechmani

Othman

Kamaludin

et al. 2021

Journal of Environmental Chemical Engineering

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Antibacterial activity of In-doped ZnO nanoparticles

Cited by 54 publications

References 64 publications

Cobalt-Doped Zinc Oxide Nanoparticle–MoS₂ Nanosheet Composites as Broad-Spectrum Bactericidal Agents

Cobalt-Doped Zinc Oxide Nanoparticle–MoS₂ Nanosheet Composites as Broad-Spectrum Bactericidal Agents

Novel fabrication of marizomib-loaded chitosan-coated hydroxyapatite nanocarriers as a promising system for effective treatment of ovarian cancer

High flux polysulfone braided hollow fiber membrane for wastewater treatment role of zinc oxide as hydrophilic enhancer

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Antibacterial activity of In-doped ZnO nanoparticles

Cited by 54 publications

References 64 publications

Cobalt-Doped Zinc Oxide Nanoparticle–MoS2 Nanosheet Composites as Broad-Spectrum Bactericidal Agents

Cobalt-Doped Zinc Oxide Nanoparticle–MoS2 Nanosheet Composites as Broad-Spectrum Bactericidal Agents

Novel fabrication of marizomib-loaded chitosan-coated hydroxyapatite nanocarriers as a promising system for effective treatment of ovarian cancer

High flux polysulfone braided hollow fiber membrane for wastewater treatment role of zinc oxide as hydrophilic enhancer

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Product

Resources

About

Cobalt-Doped Zinc Oxide Nanoparticle–MoS₂ Nanosheet Composites as Broad-Spectrum Bactericidal Agents

Cobalt-Doped Zinc Oxide Nanoparticle–MoS₂ Nanosheet Composites as Broad-Spectrum Bactericidal Agents