Antibacterial activity of leaf extracts of<i>Gymnema sylvestre</i>(R. Br.)

Segarajah, Ahalya; Mikunthan, G.; Kalamathy, Murugananthan

doi:10.5958/j.0975-4261.3.2.022

Cited by 2 publications

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“…The observed activity may be due to the presence of potent phytoconstituents in the extracts. Similar results are reported in Gymnema by Kalidas and Mohan 25 . The main active compound of G. sylvestre is gymnemic acid, saponins and oleanane type of triterpenoid.…”

Section: Discussionsupporting

confidence: 90%

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2015

IJPSR

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The present investigation deals with preliminary phytochemical analysis and in vitro antibacterial potentials of different solvent extracts of Gymnema sylvestre were demonstrated. The phytochemical tests of the extracts have revealed the presence of alkaloids, flavonoids, phenols, tannins, terpenoids carbohydrate, tannin, and saponin. Five gram-positive (Bacillus cereus, Bacillus subtilis, Streptococcus cremoris, Streptococcus fecalis, Staphylococcus aureus) and five gram-negative (Klebsiella pneumoniae, Proteus vulgaris, Salmonella paratyphi, Shigella boydi, Shigella dysentriae) bacterial strains were tested. The ethanol extracts have been showed encouraging results. The maximum inhibition were recorded 42.3mm in Bacillus cereus at 250µl concentration followed by E. coli (38.4mm), Streptococcus fecalis (37.2mm), Klebsiella pneumonia (35.6mm), S. aureus (33.3mm), P. aeruginosa (30.5mm), S. cremoris (28.1mm) Proteus vulgaris (26.9mm) B. subtilis (23.5mm) and least inhibition was observed in S. typhi (21.7mm). Moderate activity was observed in chloroform extract. Minimum activity was observed in hexane at different concentration tested. Compared to synthetic antibiotic Ampicillin (50mg), solvent extracts showed significant antibacterial activity. The present findings support to the traditional knowledge of the medicinal plants to the local users and plants used as therapeutic agents for treat several diseases caused by the pathogenic bacterial populations. This study confirms significant antibacterial activity of G. sylvestre.

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Section: Discussionsupporting

confidence: 90%

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2015

IJPSR

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“…Results corroborated with former reports suggests that the ethanolic extract of G. sylvestrae leaves possess superior antimicrobial activity against Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus [46]. The experimented activity may be due to the occurrence of potent phytoconstituents in the extracts, the results correlate with previous reports [47]. The chief compounds of G. sylvestre includes gymnemic acid, saponins and oleanane-type of triterpenoid.…”

Section: Uv-vis Analysis Of Synthesized Agnp Using G Sylvestraesupporting

confidence: 90%

Biogenic Potential of Stabilized Silver Nanoparticles Using G. Sylvestrae and Their Biological Assays

Anburaj¹,

Jothiprakasam²

2019

Int J App Pharm

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Objective: The idea of green chemistry has gained immense fame due to replace chemical products and improves technologies to eradicate substances that are harmful to the environment. In this paper, a rapid cost-efficient method was employed using herbal extract Gymnema sylvestrae because of their biological constituents present in the sample. Methods: Phytosynthesis of AgNPs were optimized under different reaction conditions using pH, temperature, incubated at various concentrations. Analyses of particles were revealed using UV-Vis, FTIR spectrum, morphology was observed in scanning electron microscope, particle analysis was done using Diffraction Light Scattering and bioactive constituents present in plant sample was analysed by High-performance liquid chromatography. Bioefficacy of synthesised AgNPs was assessed by means of microbicidal assay against various bacteria and fungi. Results: UV and FTIR analysis reveals the presence of plant extract responsible for stabilization and efficient reduction. Peptides to proteins, polyphenols, and many other secondary metabolites involved in the bioreduction were identified. SEM micrograph reveals the nature, size and distribution of the sample. HPLC chromatogram indicated the presence of gymnemagenin responsible for their biological assays. Broad spectrum of microbicidal activity have been reported in 400 µl of biosynthesized AgNPs against Bacillus sp. (24.5 mm), and S. epidermis (22.3 mm). Conclusion: Therefore G. sylvestrae synthesized silver nanoparticles were stable and acts as a reducing and capping agent detecting the presence of biomolecules. Biosynthesised AgNPs showing excellent antimicrobial activity and future prospects of this study indicates that these nanoparticles can be applied in drug delivery.

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Antibacterial activity of leaf extracts ofGymnema sylvestre(R. Br.)

Cited by 2 publications

References 0 publications

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Biogenic Potential of Stabilized Silver Nanoparticles Using G. Sylvestrae and Their Biological Assays

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