Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids

Адамович, С. Н.; Sadykov, E. Kh.; Ushakov, Igor А.; Оборина, Е. Н.; Беловежец, Л. А.

doi:10.1016/j.mencom.2021.03.019

Cited by 17 publications

(10 citation statements)

References 54 publications

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“…Pyrrole has long been known to react with trichloroacetic anhydride to give the 2-(trichloroacetyl)pyrrole, which can then undergo substitution with a variety of nucleophiles. 50 Typical derivatization includes formation of the benzylester, 51 amide, 52 and carboxylic acid 53 moieties. Here, the Nazarov product 6-HH was treated with trichloroacetic anhydride 54 to give the trichloroacetyl product 7 , which was isolated by simple filtration in 71% yield (Scheme 6, top).…”

Section: Resultsmentioning

confidence: 99%

Synthesis of model southern rim structures of photosynthetic tetrapyrroles and phyllobilins

Tran

Chung

et al. 2023

New J. Chem.

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Section: Resultsmentioning

confidence: 99%

Synthesis of model southern rim structures of photosynthetic tetrapyrroles and phyllobilins

Tran

Chung

et al. 2023

New J. Chem.

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“…APS ( 1 ) and 2-(trichloroacetyl)pyrroles were used as precursors to obtain hitherto unknown 1 H -R-pyrrole-2-carboxamidesilatrane hybrids ( 18 ) ( Figure 5 ) [ 52 ]. The starting silatrane ( 1 ) and pyrrolcarboxamide-linked silatranes ( 18a – d ) were checked in vitro for antimicrobial activity against bacterial strains of Gram-positive Enterococcus durans , Bacillus subtilis, and Gram-negative Escherichia coli .…”

Section: Silatranyl Physiologically Active Compoundsmentioning

confidence: 99%

3-Aminopropylsilatrane and Its Derivatives: A Variety of Applications

et al. 2022

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Silatranes arouse much research interest owing to their unique structure, unusual physical–chemical properties, and diverse biological activity. The application of some silatranes and their analogues has been discussed in several works. Meanwhile, a comprehensive review of the wide practical usage of silatranes is still absent in the literature. The ability of silatranes to mildly control hydrolysis allows them to form extremely stable and smooth siloxane monolayers almost on any surface. The high physiological activity of silatranes makes them prospective drug candidates. In the present review, based on the results of numerous previous studies, using the commercially available 3-aminopropylsilatrane and its hybrid derivatives, we have demonstrated the high potential of 1-organylsilatranes in various fields, including chemistry, biology, pharmaceuticals, medicine, agriculture, and industry. For example, these compounds can be employed as plant growth biostimulants, drugs, optical, catalytic, sorption, and special polymeric materials, as well as modern high-tech devices.

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“…Its derivatives are, moreover, present in the majority of synthetic and natural drug chemical structures. As well as playing a key role in organic synthesis, pyrrole derivatives have biological signi cance activities including antimalarial 11 , antitumor 12 , antiallergic 13 , fungicidal 14 , antiviral 15 , antidiabetic 16 , antibacterial 17 , antioxidant 18 , antitubercular 19 , anti-in ammatory agents 20 , and tyrosine kinase inhibiting agents 21 . Various strategies are employed to prepare these precious compounds, namely Hantzsch 22 , Paal-Knorr 23 , transition metal-catalyzed 24 , and multicomponent couplings.…”

Section: Introductionmentioning

confidence: 99%

A facile and efficient synthesis of highly functionalized pyrroles via a four-component one-pot reaction in the presence of Ni(II) Schiff base/SBA-15 heterogeneous catalyst

et al. 2023

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Under favorable conditions, we have designed a one-pot multicomponent reaction combining aromatic amines, aldehydes, nitroalkanes, and 1-dicarbonyl compounds in conjunction with the presence of the Ni(II)-Schiff base/SBA-15 as a heterogeneous catalyst to generate a range of functionalized pyrroles in reasonable to excellent yields. We present a methodology that results in a high yield percentage, a short reaction time of approximately 8 hours, mild reaction conditions of 70°C, a wide range of substrates, the possibility of large-scale synthesis, low cost, and the avoidance of hazardous reagents/solvents. In addition, this method can synthesize more desirable pyrroles by adding or altering numerous functional groups to the reactants in a one-pot process. Speci cally, a Hammett plot variant was employed to evaluate the reaction effectively.

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Antibacterial activity of new silatrane pyrrole-2-carboxamide hybrids

Cited by 17 publications

References 54 publications

Synthesis of model southern rim structures of photosynthetic tetrapyrroles and phyllobilins

Synthesis of model southern rim structures of photosynthetic tetrapyrroles and phyllobilins

3-Aminopropylsilatrane and Its Derivatives: A Variety of Applications

A facile and efficient synthesis of highly functionalized pyrroles via a four-component one-pot reaction in the presence of Ni(II) Schiff base/SBA-15 heterogeneous catalyst

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