Antibacterial activity of novel insoluble bead‐shaped polymer‐supported multiquaternary ammonium salts

Abstract

This study describes the effect of antibacterial activity of newly reported five different novel insoluble bead-shaped polymer-supported multiquaternary ammonium salts (PM quats) viz., bis-quat, tris-quat (2 Nos.), tetrakis-quat, hexakis-quat containing two, three, four, and six quaternary ammonium groups, respectively. The presence of number of quaternary ammonium groups in each salt was established already through Fourier-transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, and chloride ion analyzes. The antibacterial activities of these five different PM quats against three different bacteria viz., Staphylococcus aureus, Klebsiella pneumoniae, and Pseudomonas aeruginosa were investigated by serial dilution and spread plate method and compared the same with a monoquat containing single quaternary ammonium group. The extent of antibacterial activity has been measured in terms of colony forming units (CFU) at different time intervals. The observed results show that all the PM quats exhibited excellent-antibacterial activity against each bacterium. On the basis of the CFU values, the antibacterial activity was found to increase from bis-quat to hexakis-quat, which reveals that the activity of PM quats increases with increase in the number of quaternary ammonium groups. The mechanism of interaction of quats with bacterial cytoplasmic membrane has been explained as an adsorption-like phenomenon. The reusability of highly active hexakis-quat against Staphylococcus aureus was studied and the activity was found to reduce after first cycle.

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“…Antimicrobial activity of cationic porphyrin-grafted cotton, when used in darkness, that we observed against S. aureus is reminiscent of other observations conducted with insoluble cationic polymers, which acted upon bacteria by simple adsorption. ,− The reason why cationic cellulose only acted upon S. aureus, although unexplained, is presently under scrutiny.…”

Synthesis and characterization of new soluble multisite phase transfer catalysts and their catalysis in free radical polymerization of methyl methacrylate aided by ultrasound—A kinetic study

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Antimicrobial Agents for Textiles: Types, Mechanisms and Analysis Standards

“…The QACs showed excellent antibacterial activity against S.aureus, Klebsiella pneumonia and Pseudomonas aeruginosa (P.aeruginosa). Murugan et al also found that the antibacterial activity increased as the number of QACs in the structure increased [41]. However, there are also reports of bacterial resistance to QACs [42,43].…”

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