Antibacterial activity of Sapindus saponins against microorganisms related to food hygiene and the synergistic action mode of Sapindoside A and B against Micrococcus luteus in vitro

Wei, Minping; Yu, Hang; Guo, Yahui; Cheng, Yuliang; Xie, Yunfei; Yao, Weirong

doi:10.1016/j.foodcont.2021.108337

Cited by 20 publications

(5 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, compound C 2 exerted a stronger effect than KI and caused a significant change in the protein environment and conformation in the Xoo membrane. A red shift in the maximum emission of these residues is due to increased solubility . We observed the same phenomenon here, such as 333–338 nm for Phe and 335–341 nm for Trp.…”

Section: Resultssupporting

confidence: 84%

Engineering Phenothiazine-Based Functional Mimics of Host Defense Peptides as New Agrochemical Candidates: Design, Synthesis, and Antibacterial Evaluation

Shao,

Luo,

Meng

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

In the protracted "arms race" between host and plant pathogenic bacteria, host organisms have evolved powerful weapons known as host defense peptides (HDPs). However, natural HDPs are not suitable for large-scale applications; therefore, researchers have chosen to develop bespoke small-molecule functional mimics. Phenothiazine derivatives were developed as functional HDPs mimics, owing to their broad biological activity and high lipophilicity. The phenothiazine analogues designed in this study exhibited excellent in vitro bioactivity against the three Gram-negative bacteria Xanthomonas oryzae pv oryzae, Xanthomonas axonopodis pv citri, and Pseudomonas syringae pv actinidiae, with optimal EC 50 values of 0.80, 0.31, and 1.91 μg/mL, respectively. Preliminary evidence suggests that compound C 2 may act on bacterial cell membranes and interact with bacterial Deoxyribonucleic acid in the groove binding mode. In vivo trials showed that compound C 2 was highly effective against rice leaf blight (51.97−56.69%), with activity superior to those of bismerthiazol (40.7−43.4%) and thiodiazole copper (30.2−37.1%). Our study provides strong evidence to support the development of phenothiazine derivatives into pesticide candidates.

show abstract

Section: Resultssupporting

confidence: 84%

Engineering Phenothiazine-Based Functional Mimics of Host Defense Peptides as New Agrochemical Candidates: Design, Synthesis, and Antibacterial Evaluation

Shao,

Luo,

Meng

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…This activity is related to its ability to increase bacteria cell membrane permeability, leading to hemolysis. 41 Other than that, saponin may also increase collagen production and accelerate cell epithelization in the wound. 42 Saponin also had an essential role in high glucose-induced wound healing by increasing endothelial cell proliferation.…”

Section: Resultsmentioning

confidence: 99%

Wound healing activity and flavonoid contents of purslane (Portulaca grandiflora) of various varieties

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The calculated average binding energies were −86.94 ± 1.99 and −105.01 ± 1.19 kcal/mol, respectively, which indicated that camelliagenin can spontaneously bind to both MDH and eDNA and modulate their function. In addition, Wei et al examined the synergistic antibacterial activity of Sapindoside A and B against M. luteus [111]. The experimental data indicated the antibacterial activity of this combination was achieved by attacking the cell membrane proteins.…”

Section: Molecular Docking Studiesmentioning

confidence: 99%

In Vitro and In Silico Studies of Antimicrobial Saponins: A Review

Li,

Monje-Galvan

2023

Processes

View full text Add to dashboard Cite

Antibiotics are important drugs for the treatment of microbial infections and related diseases. However, due to the abuse of antibiotics, drug resistance has become a serious and urgent problem. The development of new antibiotics is a crucial area of research, and natural products are one of the main sources of novel antibiotics. Among various potential natural antimicrobial products, saponins attracted much attention due to their excellent and broad-spectrum antimicrobial properties. Although there are several reviews on antibacterial saponins, this review is the first to highlight the potential antibacterial mechanisms of saponins from both experimental and molecular simulation perspectives to provide a comprehensive panorama of the field. This review presents the current progress in the development and repurposing of natural-product antibiotics. The focus is centered on antimicrobial saponins discovered in recent years as well as the synergistic effect of some saponins with traditional antibiotics. This review presents experimental and simulation studies in this field to provide a multiscale overview of the antimicrobial mechanisms of saponins and potential directions for future research.

show abstract

Antibacterial activity of Sapindus saponins against microorganisms related to food hygiene and the synergistic action mode of Sapindoside A and B against Micrococcus luteus in vitro

Cited by 20 publications

References 44 publications

Engineering Phenothiazine-Based Functional Mimics of Host Defense Peptides as New Agrochemical Candidates: Design, Synthesis, and Antibacterial Evaluation

Engineering Phenothiazine-Based Functional Mimics of Host Defense Peptides as New Agrochemical Candidates: Design, Synthesis, and Antibacterial Evaluation

Wound healing activity and flavonoid contents of purslane (Portulaca grandiflora) of various varieties

In Vitro and In Silico Studies of Antimicrobial Saponins: A Review

Contact Info

Product

Resources

About