Sargassum polycystum , a brown seaweed, contains various nutrients and bioactive compounds that have antioxidant and healing properties. Sargassum polycystum (sargassaceae) is a marine species found in large communities on rocks in lower intertial zone in relatively calm water. The medicinal algae is also called as Sargassum polycystum , HalimiumLasianthum and Sargaco in Portuguese. These are nutritious and rich source of bioactive compound such as vitamins, carotenoids, dietary fibers, protein and minerals. And also it contain biologically active compound like terpenoids, flavonoids, sterols, sulfated polysaccharides, polyphenols, sargaquinoic acids, sargachromenol, pheophytine when isolated using distillation processes. These isolated compounds exhibit different biological activities like analgesic, hepotoprotective property, Anti-bacterial and anti-microbial activity, Anti-diabetic activity, Antiwrinke activities and skin-whitening activity (cosmetic industry), neuroprotective, anticoagulant, antiviral activity etc,. Hence Sargassum polycystum have great potential to be used in pharmaceutical and nutraceutical areas. This review paper explores varies therapeutic potential and health benefits of Sargassum polycystum