Antibacterial activity of silver nanoparticles functionalized with amikacin applied against multidrug-resistant acinetobacter baumannii

In Vitro Antibacterial Activity of Silver Nanoparticles Conjugated with Amikacin and Combined with Hyperthermia against Drug-Resistant and Biofilm-Producing Strains

“…These results correlate with those of Kaur and Kumar ( 44 ), who tested the bactericidal effect of AgNPs conjugated with AK on S. aureus and E. coli and observed an enhanced effect of the complex in comparison with the antibiotic alone ( 44 ). The results of our study also correlate with those of a previous study by Camargo et al ( 45 ), who studied the antibacterial activity of AgNPs functionalized with AK and obtained an MIC value of <0.5 μg/mL against MDR A. baumannii strains, which was similar to our values. However, in our study, we also obtained promising results against other MDR/XDR clinical strains.…”

Chemical Method for Recovery and Regeneration of Graphene Oxide

“…It is widely accepted that Ag nanoparticles are very effective antimicrobial agents, and in the presence of Ag + ions, microbial growth is reduced or stopped. Ruiz and co-workers previously reported that in the presence of Ag nanoparticles-decorated graphene oxide (Ag-GO), no bacterial growth was observed. ,, Mechanistically, silver nanoparticles release Ag + ions into the growth media and these ions inhibit the microbial growth by producing reactive oxygen species (ROS) and also by changing the intracellular functions of the microbial cells. − As shown in the Figure , clear inhibition zones devoted of bacterial growth were observed for Ag-decorated GO (Figure b, c) and rec-GO (Figure e, f) on LB agar plates inoculated with 1 × 10 7 GFP-expressing E. coli cells and cultured for 18h at 37 °C. As a control, the same experiment was repeated with GO and rec-GO without Ag nanoparticles decoration.…”

“…Mn 2 O 7 is a greenish viscous solution and it forms because of the dehydration of two HMnO 4 molecules by H 2 SO 4. Mn 2 O 7 shows its highest reactivity between 35 and 55 °C and it reduces to MnO 2 violently above 55 °C. 3 Mn 2 O 7 oxidizes the graphite surface to form oxygen functional groups, such as carboxylic, carbonyl, hydroxyl, and ether.…”

Recent advances in nanoantibiotics against multidrug-resistant bacteria

“…Moreover, the rates of Acinetobacter baumannii biofilm metabolic activity were reduced over 50% by AgNPs@amikacin, demonstrating a new strategy to rebuild the antibacterial activity of drugs that have been resisted by MDR bacteria. 141 In another study, Ag NPs were functionalized with mercaptopoly(ethylene glycol) carboxylic acid (mPEG-COOH) and amikacin (AK). AgNPs_mPEG_AK was 10-fold more effective than amikacin alone in susceptibility studies, and bactericidal efficacy against 100% of the tested Pseudomonas aeruginosa after 4, 8, 24, or 48 h. AgNPs_mPEG_AK combined with hyperthermia achieved a 75% eradication of planktonic strains and significantly reduced the biofilm formation.…”