Antibacterial activity of some medicinal plant extracts

Abstract

Antibacterial activity of hot aqueous and methanolic extracts prepared from six plants (Terminallia chebula, Terminallia bellerica, Phyllanthus emblica, Punica granatum, Lawsonia alba and Mikania micrantha) used in traditional folk medicines of India were screened against five pathogenic bacteria (Staphylococcus aureus MTCC 2940, Bacillus subtilis MTCC 441, Escherichia coli MTCC 739, Proteus vulgaris MTCC 426 and Enterobacter aerogenes MTCC 111). The highest antibacterial potentiality was exhibited by the methanolic leaf extract of T. chebula, followed by the aqueous fruit extract of T. bellerica. The leaf extract of T. chebula can be considered to be as equally potent as the most effective antibiotics, such as ciprofloxacin, gentamycin, kanamycin, ofloxacin and cephalexin. A sensitivity test performed with commonly used sensitivity test disks resulted in the appearance of multiple drug resistance phenotypes of the bacteria tested. A comparison of data in the inhibition zones of pathogenic bacteria showed that gentamycin, ofloxacin, kanamycin and tobramycin were effective against all of the bacterial strains tested.

Antibacterial efficacy of the seed extracts of Melia azedarach against some hospital isolated human pathogenic bacterial strains

“…Although a significant number of studies have been used to obtain purified phytochemicals, a very few screening programmes have been initiated on crude plant materials. It has also been widely observed and accepted that the medicinal value of plants lies in the bioactive phytocomponents present in the plants [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] . The results of the present study are encouraging as all the tested extracts revealed antibacterial potential, although the inhibitory activity was strain specific and concentration dependent.…”

In vitro antibacterial and antioxidant activities of alcoholic extract from the leaves of Podocarpus neriifolius D. Don

“…Among the seven bacteria, this extract produced greatest inhibition against S. paratyphi and S. typhi. Literature revealed that, herbal products from the natural resources represent a promising source of antimicrobial agents for the reason that they are natural and affordable, particularly for rural communities (Ghosh et al, 2008). Approval of medicines from herbal sources as another form of medical care is increasing since they are serving as sources of novel antibiotic prototypes.…”

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“…Tumour suppressor genes are under expressed in cancer cells while, oncogenes are over expressed 23 . Summarizes the main oncogenes and tumour suppressor genes and their role in cancer development.…”