Antibacterial activity of some selected medicinal plants of Pakistan

Bibi, Yamin; Nisa, Sobia; Chaudhary, Fayyaz M; Zia, Muhammad

doi:10.1186/1472-6882-11-52

Cited by 143 publications

(96 citation statements)

References 25 publications

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“…Recent emergence of antibiotic resistance and related toxicity issues limit the use of antimicrobial agents [11] and is prompting a revival in research of the antimicrobial role of plants against resistant strains due to comparable safety and effi cacy [1]. In Pakistan, a diverse fl ora of medicinal plants is grown naturally [12,13].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial activity of some medicinal plants against selected human pathogenic bacteria

Khan¹,

Rahman²,

Niaz³

et al. 2013

European Journal of Microbiology and Immunology

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Medicinal plants are traditionally used for the treatment of human infections. The present study was undertaken to investigate Bergenia ciliata, Jasminum officinale, and Santalum album for their potential activity against human bacterial pathogens.B. ciliata, J. officinale, and S. album extracts were prepared in cold and hot water. The activity of plant extracts and selected antibiotics was evaluated against five bacterial pathogens including Staphylococcus aureus, Bacillus subtilis, Proteus vulgaris, Pseudomonas aeruginosa, and Escherichia coli using agar well diffusion method.Among the three medicinal plants, B. ciliata extracts displayed potential activity against bacterial pathogens. Cold water extract of Bergenia ciliate showed the highest activity against B. subtilis, which is comparable with a zone of inhibition exhibited by ceftriaxone and erythromycin. J. officinale and S. album extracts demonstrated variable antibacterial activity. Further studies are needed to explore the novel antibacterial bioactive molecules.

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Section: Introductionmentioning

confidence: 99%

Antibacterial activity of some medicinal plants against selected human pathogenic bacteria

Khan¹,

Rahman²,

Niaz³

et al. 2013

European Journal of Microbiology and Immunology

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“…The total yield of the plant and callus extracts was recorded 78 g and 14 g, respectively. Dried extract Micropropagation of Caralluma tuberculata 343 weighing 2.5 g were independently suspended in 100 mL of doubled distilled water and screened with 300 mL each of n-hexane, ethyl acetate and n-butanol, successively (Bibi et al 2011a). The different partitioned fractions of n-hexane, ethyl acetate, n-butanol and finally water were collected separately and dried using rotary evaporator and stored at -80…”

Section: Extraction and Fractionationmentioning

confidence: 99%

In vitro propagation of Caralluma tuberculata and evaluation of antioxidant potential

Rehman

Chaudhary

Khawar³

et al. 2014

Biologia

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Present study describes rapid in vitro propagation of Caralluma tuberculata, a traditional medicinal plant, and antioxidant potential of calli and plants extracts. The highest callus induction rate (93.3%) with maximum weight of calli 5.2 g was achieved from shoot tip explants on MS medium supplemented with 9.04 µM 2,4-D and 4.44 µM BA. The maximum shoot induction rate (71.1%) with mean number of shoots 3.66 ± 1.53 and 4.6 cm average shoot length was observed on 13.32 µM BA, 4.52 µM 2,4-D and 2.89 µM GA3 appended in MS medium. The developed shoots were best rooted in the presence of 5.07 µM IAA with 3.0 ± 0.15 roots per plantlet. The plants were successfully acclimatized under in vivo conditions. The plants and calli extracts exhibited good antioxidant activities, however, plant extract activities were more pronounced. The phenolic compounds in plant and calli extracts were 0.16% and 0.057%, respectively. While the flavonoids were 0.092% in plant and 0.039% in calli extract. Total Phenolics, flavonoids; DPPH radical scavenging activity and reducing power potential distributed among different fractions depending upon polarity of the solvent. The highest DPPH scavenging activity and reducing power was exhibited by water fractions; 4.95 mg/mL and 0.729 OD at 10 mg/mL, respectively. The micropropagation protocol can be successfully used for large-scale multiplication and conservation of germplasm of this threatened plant. Furthermore, antioxidant value describes importance of this valuable plant as food and medicine.

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“…20 µL of lipoxygenase (LOX) solution (enzyme 130 units per well) was added, mixed and incubated for 10 min at 25 °C. The reaction was then initiated by the addition of 10 µL substrate solution (linoleic acid, 0.5 mM, 0.12 %w/v tween 20 in ratio of 1:2) in each well and the absorbance was measured after 15 min at 234 nm 12 .…”

Section: Physical Measurementsmentioning

confidence: 99%

A One-Pot Synthesis, Characterization and Pharmacological Investigations: Schiff Bases

Aslam¹

2012

Int J Pharmceut Chem

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ABSTRACT:Two biologically active Schiff bases, C 13 H 10 BrON (4), C 13 H 9 Br 2 O 2 N (5), were synthesized by the reaction of 2-aminophenol (1) with 3-bromobenzaldehyde (2) or 3,5-dibromo-4-hydroxybenzaldehyde (3) in the presence of conc. H 2 SO 4 . The characterization of Schiff bases were carried out by using spectroscopic techniques including IR, 1 H-NMR, FAB-MS along with elemental analyses. The Schiff bases were checked for biological screening and Schiff base (4) was found to be potent antioxidant agent while Schiff base (5) showed non-significant antioxidant activity. In enzyme inhibition, the lipoxygenase inhibition activity was found to be moderate for Schiff base (4) and significant for Schiff base (5). The Schiff bases (4-5) also have excellent antibacterial activity for strains; Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa, using gentamicin as standard drug. Keyword: Schiff base, lipoxygenase inhibition activity, urease inhibition activity IntroductionThe Schiff bases are the compounds having azomethine linkage (Figure 1) and can be synthesized from an amino and a carbonyl compound. These are significant chelating ligands in co-ordination chemistry to co-ordinate metals ions through azomethine nitrogen and have been considered broadly 1 . The imine or azomethine moieties are present in a range of natural, natural-derived, and non-natural compounds 2 . The biological activities of Schiff bases have been revealed due to the imine moiety present in these compounds [3][4][5][6] . The Schiff bases have broad applications in food and dye industries, and in analytical chemistry, catalysis and also in the field of agrochemical 7 . These have played an influential part in the improvement of modern coordination chemistry, but also they can also be found at key points in the development of inorganic biochemistry, catalysis and also in optical materials 8 . Keeping the above facts in mind and as part of ongoing efforts on Schiff bases 9 , in the present paper the synthesis, characterization and biological activities of the Schiff bases (4-5) were investigated and reported.

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Antibacterial activity of some selected medicinal plants of Pakistan

Cited by 143 publications

References 25 publications

Antibacterial activity of some medicinal plants against selected human pathogenic bacteria

Antibacterial activity of some medicinal plants against selected human pathogenic bacteria

In vitro propagation of Caralluma tuberculata and evaluation of antioxidant potential

A One-Pot Synthesis, Characterization and Pharmacological Investigations: Schiff Bases

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