Antibacterial activity of the anti-inflammatory compound ibuprofen

Elvers, Karen T; Wright, S. J. L.

doi:10.1111/j.1472-765x.1995.tb01291.x

Cited by 71 publications

(46 citation statements)

References 2 publications

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“…In considering the clinical relevance of the antimicrobial effects of antipyretics, it is important to understand that the reported MICs of antipyretic drugs vary, sometimes considerably, according to the culture medium, incubation temperature, and pH used. Inhibition of growth is greater at pHs lower than 7 (7,8,19,84). The use of different temperatures and pH conditions in the studies summarized in Table 1 limits comparison.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Effects of Antipyretics

Zimmermann

Curtis

2017

Antimicrob Agents Chemother

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Antipyretics are some of the most commonly used drugs. Since they are often coadministered with antimicrobial therapy, it is important to understand the interactions between these two classes of drugs. Our review is the first to summarize the antimicrobial effects of antipyretic drugs and the underlying mechanisms involved. Antipyretics can inhibit virus replication, inhibit or promote bacterial or fungal growth, alter the expression of virulence factors, change the surface hydrophobicity of microbes, influence biofilm production, affect the motility, adherence, and metabolism of pathogens, interact with the transport and release of antibiotics by leukocytes, modify the susceptibility of bacteria to antibiotics, and induce or reduce the frequency of mutations leading to antimicrobial resistance. While antipyretics may compromise the efficacy of antimicrobial therapy, they can also be beneficial, for example, in the management of biofilm-associated infections, in reducing virulence factors, in therapy of resistant pathogens, and in inducing synergistic effects. In an era where it is becoming increasingly difficult to find new antimicrobial drugs, targeting virulence factors, enhancing the efficacy of antimicrobial therapy, and reducing resistance may be important strategies.

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Effects of Antipyretics

Zimmermann

Curtis

2017

Antimicrob Agents Chemother

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“…However, the risk for infection in children was 6.9% lower with BNZD compared with SO, indicating that the effect also exists when BNZD is used as an adjuvant to ibuprofen, a compound that also possesses some antibacterial activity. 35 Further research could clarify the extent to which topical BNZD contributes to infection risk reduction.…”

Section: Discussionmentioning

confidence: 99%

Comparison of benzydamine hydrochloride and Salvia officinalis as an adjuvant local treatment to systemic nonsteroidal anti-inflammatory drug in controlling pain after tonsillectomy, adenoidectomy, or both: an open-label, single-blind, randomized clinical trial

Lalićević¹,

Djordjević²

2004

Current Therapeutic Research

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Background: Benzydamine hydrochloride (BNZD) is a nonsteroidal antiinflammatory drug (NSAID) used in an oral rinse formulation as an adjuvant to other NSAIDs in controlling postoperative pain after tonsillectomy, adenoidectomy, or both. Salvia officinalis (SO) is a topically applied herbal preparation frequently used for the same indication. Pain, bleeding, and infection are the most common postoperative complications of tonsillectomy.Objective: The aim of this study was to compare the efficacy and tolerability of BNDZ with those of SO as adjuvant treatments in controlling postoperative pain.Methods: This open-label, single-blind, randomized clinical trial was conducted at the Department of Otorhinolaryngology, Clinical Hospital Center "Dr. Dragi~a Mi~ovi~--Dedinje" (Belgrade, Serbia and Montenegro). Pediatric and adult patients undergoing tonsillectomy, adenoidectomy, or both were enrolled. Patients were randomized to receive BNZD or SO, in addition to ibuprofen 20 mg/kg.d (children) or diclofenac 100 mg/d (adults). The primary end point was the proportion of patients with mild or no pain on postoperative days 1, 2, 4, and 7. Secondary end points were the incidences of infection, hemorrhage, and other adverse events. Results: S. Lali~evi6 and L Djordjevi~time point (P < 0.01 at days 1 and 4; P < 0.001 at days 2 and 7). In children, the risk for postoperative infection was similar between BNZD and SO (absolute risk reduction [ARR], 6.9%; 95% CI, 6.4%-?.6%); however, the risk was reduced in adults (ARR, 19.0%; 95% CI, 16.5%-21.9%; P = 0.008). Conclusions:In this clinical trial of children and adults who underwent tonsillectomy, adenoidectomy, or both, BNZD, as an adjuvant to an NSAID, was more effective than SO in controlling postoperative pain and infection. The pain-reducing effect of BNZD was of quick onset and persisted for 1 week after surgery. The safety profile of BNZD was comparable to that of SO, with the exception of postoperative infection in adults, for which BNZD was more efficacious. In particular, the use of BNZD was not associated with a high risk for early postoperative hemorrhage. (Curt Ther Res Clin Exp.

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“…At present only for few pharmaceutical substances (aspirin, caffeine, clofibrate, ciclofosphamide, oestrogens, ibuprofen, naproxen) literature information on the biodegradability are available [7,[12][13][14][15]. Moreover, most studies refer to the toxicity for living organisms of antibiotic type substances [13][14][15][16][17][18][19] showing effects in the endocrine system of fish [20] even at levels of some ng/L. The results so far reported suggest considering the presence of pharmaceutical substances in the environment a risk for human health and for living species, even at very low concentration levels [21].…”

Section: Introductionmentioning

confidence: 99%