Antibacterial Activity of the Essential Oil of <i>Heracleum Sibiricum</i>

Miladinović, Dragoljub L.; Ilić, Budimir S.; Mihajilov‐Krstev, Tatjana; Nikolic, D. M.; Cvetković, Olga; Marković, Marija; Miladinović, Ljiljana C.

doi:10.1177/1934578x1300800931

Cited by 10 publications

(12 citation statements)

References 13 publications

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“…In a Serbian population of H. sibericum, octyl butyrate (36.82%) and hexyl butyrate (16.08%) were found to be the major compounds. [19] Hexyl butyrate has also been reported in other species of Apiaceae such as Pastinaca sativa. [43] There was a considerable variation in the amount of several less abundant compounds among species.…”

Section: Major Geographic Patterns Of Essential Oil Constituents In Hmentioning

confidence: 99%

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Large Scale Geographical Mapping of Essential Oil Volatiles in Heracleum (Apiaceae): Identification of Novel Compounds and Unraveling Cryptic Variation

Falahati‐Anbaran

Bazargani

Rohloff

2018

Chemistry & Biodiversity

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Conspecific populations of plants in their native range are expected to show considerable variation due to long-term ecological and evolutionary factors. We investigated the levels of secondary metabolites in Heracleum including H. persicum a valuable medicinal plant to depict the magnitude of cryptic variation and the potential significance of novel chemical traits. The essential oil volatiles from fruits of 34 populations from different species of Heracleum in Iranian distribution range and a native of H. sphondylium and an invasive population of H. persicum from Norway were analyzed with GC/MS. Out of 48 compounds identified, a contrasting pattern in the level of two major compounds, octyl acetate and hexyl butyrate was found among all studied species. Interestingly, a significant geographic pattern was observed; the hexyl butyrate/octyl acetate ratio was high (range 1.8 - 3.2) in the northwestern Iranian populations of H. persicum compared to that in northern and central populations (range 0.3 - 0.9). Four populations from Zagros mountains also exhibited a unique composition. Anethole was found in two populations of H. persicum from central Zagros, which has not been previously reported for essential oil of fruits of Heracleum so far. The results suggest high efficiency of large scale sampling from distribution range of species in identifying novel compounds. The unique pattern of geographic structuring also provides novel information to unravel cryptic variation in Heracleum.

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Section: Major Geographic Patterns Of Essential Oil Constituents In Hmentioning

confidence: 99%

“…The biological and pharmacological importance of the plant has already been reported and reviewed elsewhere. [ ][ ] Leaves are being used as foliage to feed livestock and vegetable for human consumption. Heracleum seeds have been used not only as food stuff, additive and spice, but also as traditional folk medicine.…”

Section: Introductionmentioning

confidence: 99%

Large Scale Geographical Mapping of Essential Oil Volatiles in Heracleum (Apiaceae): Identification of Novel Compounds and Unraveling Cryptic Variation

Falahati‐Anbaran

Bazargani

Rohloff

2018

Chemistry & Biodiversity

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“…The GC, GC-MS analyses and identification of oil compounds were performed as previously described [3]. [24].…”

Section: Gas Chromatography Gas Chromatography/mass Spectrometry Andmentioning

confidence: 99%

In vitro Antibacterial Activity of Libanotis montana Essential Oil in Combination with Conventional Antibiotics

Miladinović

Ilić

Mihajilov‐Krstev

et al. 2014

Natural Product Communications

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The chemical composition and antibacterial activity were examined of Libanotis montana Crantz subsp. leiocarpa (Heuff.) Soó. (Apiaceae) essential oil. Gas chromatography and gas chromatography/mass spectrometry were used to analyze the chemical composition of the oil. The antibacterial activity was investigated by the broth microdilution method against thirteen bacterial strains. The interactions of the essential oil and three standard antibiotics: tetracycline, streptomycin and chloramphenicol toward five selected strains were evaluated using the microdilution checkerboard assay in combination with chemometric methods: principal components analysis and hierarchical cluster analysis. Sesquiterpene hydrocarbons were the most abundant compound class in the oil (67.2%), with -elemene (40.4%) as the major compound. The essential oil exhibited slight antibacterial activity against the tested bacterial strains in vitro, but the combinations L. montana oil-chloramphenicol and L. montana oil-tetracycline exhibited mostly either synergistic or additive interactions. These combinations reduced the minimum effective dose of the antibiotics and, consequently, minimized their adverse side effects. In contrast, the association of L. montana essential oil and streptomycin was characterized by strong antagonistic interactions against Escherichia coli ATCC 25922. In the PCA and HCA analyses, streptomycin stood out and formed a separate group.

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“…Miladinović et al 27 investigated the composition of the essential oil isolated from the aerial parts of H. sibiricum collected on Mt. Vidlič (Serbia), but plant organs included in the analyzed aerial parts were not specified.…”

Section: Chemical Composition Of Essential Oilsmentioning

confidence: 99%

Essential oils of three cow parsnips – composition and activity against nosocomial and foodborne pathogens and food contaminants

et al. 2017

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Although some widespread, native cow parsnips (Heracleum L. spp., Apiaceae) had broad medicinal and culinary applications throughout history, the knowledge about their volatile constituents is insufficient. This work investigates the composition and bioactivities of H. sphondylium L. (HSPH), H. sibiricum L. (HSIB) and H. montanum Schleich. ex Gaudin (HMON) essential oils. The composition was tested by GC and GC-MS. (Z)-β-Ocimene was the most abundant in HSPH (28.9%) and HMON (20.4%) root oils, while in HSIB root oil, β-pinene (26.2%), methyl eugenol (22.3%) and elemicin (25.6%) prevailed. Leaf and flower oils were dominated by various sesquiterpenes (germacrene D, β-sesquiphellandrene, (E)-β-farnesene and/or (E)-caryophyllene) and/or phenylpropanoids (apiole, methyl eugenol, elemicin and/or (Z)-isoelemicin). Octyl acetate (57.5-67.1%) was the main constituent of all fruit oils. The antimicrobial activity was screened by a microdilution method against eight bacteria and eight fungi. The strongest antimicrobial effect, in several cases better than the activity of antibiotics, was shown by HSPH (MICs = 0.12-3.30 mg mL) and HMON (MICs = 0.10-1.30 mg mL) flower oils against bacteria, and HSIB fruit oil against fungi (MICs = 0.15-0.40 mg mL). The MTT test revealed that the oils were not or weakly cytotoxic against human malignant HeLa, LS174 and/or A549 cells (except HSPH root oil; IC = 5.72-24.31 μg mL) and that tested oils were not toxic against human normal MRC-5 cells (at 200.00 μg mL). Significant activity observed against microorganisms that are the common cause of foodborne diseases, food contamination and/or hospital-acquired infections justifies certain traditional uses of the investigated plants and represents a good basis for further research of these Heracleum oils.

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Antibacterial Activity of the Essential Oil of Heracleum Sibiricum

Cited by 10 publications

References 13 publications

Large Scale Geographical Mapping of Essential Oil Volatiles in Heracleum (Apiaceae): Identification of Novel Compounds and Unraveling Cryptic Variation

Large Scale Geographical Mapping of Essential Oil Volatiles in Heracleum (Apiaceae): Identification of Novel Compounds and Unraveling Cryptic Variation

In vitro Antibacterial Activity of Libanotis montana Essential Oil in Combination with Conventional Antibiotics

Essential oils of three cow parsnips – composition and activity against nosocomial and foodborne pathogens and food contaminants

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