Antibacterial activity of the leaves of Phyllanthus discoideus

Securinega Alkaloids from Flueggea leucopyra

“…1) Previous phytochemical investigations had led to the isolation of a number of Securinega alkaloids, [1][2][3][4][5][6][7][8] which exhibited antimalarial, antibacterial and antitumor activities. [8][9][10][11] Among the Securinega alkaloids, securinine was a major alkaloid obtained from the plant Securinega suffruticosa, 12) and clinically applied to treat sequela of poliomyelitis and aplastic anemia. 13) Pharmacology investigations indicated that securinine was a stereospecific GABA A receptor antagonist with a significant central nervous system (CNS) activity.…”

The Securinega Alkaloids

“…122 Securinine (1) and virosecurinine (2) also exhibited antibacterial activities on Escherichia coli, Enterococcus faecium, Mycobacterium smegmatis, Pseudomonas aeruginosa, and Staphyloccocus aureus. 123 The minimal inhibitory concentrations (MIC) are between 0.22 mM for virosecurinine (2) against S. aureus and P. aeruginosa, and 4.6 mM for securinine (1) against E. faecium.…”

Analysis of Securinega-type alkaloids from Phyllanthus glaucus biomass

“…It also can significantly decrease acetylocholiesterase activity and reduce glial inflammatory responses induced by b-amyloid proteins (Lin and Jun-Tian, 2004). Moreover, Securinega alkaloids possess antiviral, antitumor, antibacterial, and antimalarial activity, and can induce apoptosis of human leukemia HL-60 cells (Dong et al, 1999;Mensah et al, 1990;Zhang et al, 2011).…”