Antibacterial activity of two biflavonoids from Garcinia livingstonei leaves against Mycobacterium smegmatis

Abstract

Amentoflavone and 4′ monomethoxy amentoflavone were previously isolated from Garcinia livingstonei leaves. These compounds had good activities (MIC 6 and 8 μg/ml) against some nosocomial bacteria. In this study, the activity of these purified compounds were tested against fast-growing non-pathogenic Mycobacterium smegmatis. Amentoflavone was the most active compound, with an MIC of 0.60 ± 0.70 mg/ml. The MIC of 4′ monomethoxy amentoflavone and the positive control isoniazid against Mycobacterium smegmatis were similar 1.40 ± 1.56 and 1.30 ± 1.70 mg/ml respectively. Although, Mycobacterium smegmatis is a non-pathogenic fast growing mycobacterium the activities of these compounds may also be useful in combating infections by pathogenic Mycobacterium spp.

Biflavonoids from the leaves and stem bark of Garcinia griffithii and their biological activities

“…There are several reports on Figure 1. Chemical structures of compounds isolated from G. griffithii biflavonoids isolated from the Garcinia species, such as G. hombroniana [13], G. bakeriana [14], G. subelliptica [15], G. brasiliensis [16], G. livingstonei [17], G. gardneriana [18], G. kola [19], G. multiflora [20], G. thwaitesii [21], G. densivenia [22], G. terpnophylla and G. echinocarpa [23].…”

Isolation of Six Isoprenylated Biflavonoids from the Leaves of <i>Garcinia subelliptica</i>

“…[7][8][9][10][11][12][13][14] During the last decade, the bioactivities of biflavonoids from various families have been investigated by many researchers, which has led to the identification of the different bioactivities of amentoflavone. [15][16][17] Our previous study also demonstrated that Garcinia leaves contain high quantities of biflavonoids, although the systematic preparation of a biflavonoid library and an analysis of their biological activities were not conducted. The leaves of G. subelliptica are not used as medicines, but their high biflavonoid content means they could be an important source of bioactive components.…”

“…[15][16][17] The present study and our knowledge of polyphenols suggest that the leaves of the family Clusiaceae are a major source of useful polyphenols and terpenoids, which could be applied for medicinal purposes and/or for the prevention of disease.…”

Molecular docking and quantum mechanical studies on biflavonoid structures as BACE-1 inhibitors

“…Biflavonoids are flavonoid dimers that have been attached to each other by either C-C or C-O-C bonds representing a variety of chemical structures [2]. Several biological activities such as antioxidant [3,4], antiviral [5], hypolipidemic [6], antidiabetic [7], anti-tumoral [8], antituberculosis [9], antimalarial [10], antibacterial [11], antifungal [12], and anti-inflammatory [13] effects have been reported for biflavonoids.…”