Antibacterial Activity Studies of Flavonoids From Salvia palaestina

Abstract

Ten aglycones and six glycosides of luteolin and apigenin were identified from the leaves of Salvia palaestina Bentham (Labiatae). Among them cirsimaritin showed a high activity against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, and Pseudomonas aeruginosa, while the others have little or no activity against the same bacterial strains.

Assessment of antibacterial effects of flavonoids by estimation of generation times in liquid bacterial cultures

“…In contrast to V. harveyi, growth of C. freundii, E. coli, K. pneumoniae, P. vulgaris, S. enterica and S. marcescens was unaffected or only slightly affected by all tested compounds (Table 1). Our results obtained for E. coli, K. pneumoniae and P. vulgaris corroborate conclusions reported by some authors (Miski et al 1983;Ohemeng et al 1993) but are in contrast to results described by others (Oksuz et al 1984;Bashir et al 1994;Aljancic et al 1999). The individual bacteria revealed various degrees of sensitivity to different flavonoids.…”

Antimicrobial screening of some Egyptian plants and active flavones from Lagerstroemia indica leaves

“…Moreover, several groups of researchers have noted a synergy between biologically active fl avonoids and existing chemotherapeutics (24). Flavonoids isolated from plant extracts are reported to have antimicrobial activity against food pathogenic bacteria and against C. albicans; these include compounds such as apigenin (25,26), quercetin and quercetin glycosides (27,28), luteolin (29), kaempferol (30), and fl avan derivatives. Their remarkable activity is attributed to the inhibition of nucleic acid synthesis (31), inhibition of energy metabolism (32), and inhibition of cytoplasmic membrane function (33).…”

Seasonal Variation of Free Flavone Aglycones from Sideritis leucantha (Lamiaceae)

“…T he free flavone aglycones xanthom icrol, cirsim aritin, cirsiliol, cirsilineol, 8-m ethoxycirsilineol an d sideritoflavone (5,3 ',4 '-trih y d ro x y -6 ,7 ,8 -trim ethoxyflavone) have b een isolated an d identified from Sideritis leucantha [5,6], T hese flavone agly cones exhibited also interestin g pharm acological actions. T hus, 8-m ethoxycirsilineol and cirsilineol show ed spasm olytic activity higher th an thym ol and carbacrol [10,11], cirsim aritin exhibited an tibacterial activity [12] an d all these flavones show ed an inhibi to ry effect on lense aldose redu ctase from rat [13].…”