Antibacterial AIE polycarbonates endowed with selective imaging capabilities by adjusting the electrostaticity of the mixed-charge backbone

Zhang, Junyong; Liang, Wencheng; Wen, Lianlei; Lu, Zhimin; Xiao, Yan; Lang, Meidong

doi:10.1039/d1bm00894c

Cited by 8 publications

(13 citation statements)

References 52 publications

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“…(f) Schematic diagram of P 9 and P 10 for bacterial imaging and killing. Reproduced with permission: Copyright 2021, Royal Society of Chemistry [26] . CLSM, confocal laser scanning microscope; PL, photoluminescence.…”

Section: Preparation and Features Of Novel Smart Aie Polymermentioning

confidence: 99%

“…In 2021, Lang and co‐workers designed and prepared a polycarbonate which contained three main parts, a polyethylene glycol (PEG) backbone, an AIE unit side chain and an alkene side chain, which could be used for post‐modification (Figure 6e). [26] The antimicrobial properties and selective imaging ability of polymers P 9 (cationic AIE polycarbonate) and P 10 (mixed‐charge AIE polycarbonate) could be obtained by thiol‐ene post‐modification reaction. Due to the strong positive charge of the cationic polymer P 9 , it could effectively stain gram‐positive and gram‐negative bacteria.…”

Section: Preparation and Features Of Novel Smart Aie Polymermentioning

confidence: 99%

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Smart aggregation‐induced emission polymers: Preparation, properties and bio‐applications

Zhang

Zhou

et al. 2023

Smart Molecules

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Owing to the outstanding photophysical properties, organic luminescent materials featuring aggregation-induced emission (AIE) characteristics have attracted wide attention in various fields. Numerous researches focused on low-mass AIE luminogens, and relatively less attention has been paid on AIE polymers and the related applications, in spite of the fact that AIE polymers exhibit excellent advantages of processability, multifunctional integration and synergistic effects. In this review, we briefly summarize and discuss the superiorities of AIE polymers in preparation, properties and bio-applications, and the considerable progress in these aspects are introduced as well. Finally, the structure-property relationship, challenges and opportunities are also discussed. Hopefully, this review will be a trigger for smart AIE polymer research and further broaden their applications. K E Y W O R D Saggregation-induced emission, lab-in-cell, multifunctional integration, smart polymer, synergistic amplification | INTRODUCTIONOrganic luminescent materials present significant potential in the real-time monitoring of bio-analytes and dynamic processes in living organisms, benefited from the advantages of good biocompatibility, property-structure tunability and preparation repeatability. [1] In recent years, kinds of organic fluorescent materials have been developed for bio-imaging, diagnosis and therapeutic applications with good performances. [2][3][4][5] Conventional fluorescent materials with conjugated structures display bright luminescence in the molecular state. However, these molecules will rapidly form aggregates and cause fluorescence quenching due to the strong intermolecular interactions under physiological environment, which is known as aggregation-caused quenching (ACQ) effect. This phenomenon seriously reduces the sensitivity andThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Preparation and Features Of Novel Smart Aie Polymermentioning

confidence: 99%

Section: Preparation and Features Of Novel Smart Aie Polymermentioning

confidence: 99%

Smart aggregation‐induced emission polymers: Preparation, properties and bio‐applications

Zhang

Zhou

et al. 2023

Smart Molecules

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“…Polymers bearing tertiary amine have been extensively used in antibacterial applications. [58][59][60] However, most of their backbone structures are non-degradable. Such a non-degradable property is thought a major factor causing the cytotoxicity.…”

Section: Antibacterial Activities Of Cpvchcsmentioning

confidence: 99%

Preparation of CO₂‐Based Cationic Polycarbonate/Polyacrylonitrile Nanofibers with an Optimal Fibrous Microstructure for Antibacterial Applications

Lin

Tsai

Liu

et al. 2022

Macromolecular Bioscience

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Utilizing CO 2 as one of the monomer resources, poly(vinylcyclohexene carbonates) (PVCHCs) are used as the precursor for preparing cationic PVCHCs (CPVCHCs) via thiol-ene click functionalization. Through the functionalization, CPVCHC-43 with a tertiary amine density of 43% relative to the backbone is able to display a significantly antibacterial ability against Staphylococcus aureus (S. aureus). Blending CPVCHC-43 with polyacrylonitrile (PAN), CPVCHC/PAN nanofiber meshes (NFMs) have been successfully prepared by electrospinning. More importantly, two crucial fibrous structural factors including CPVCHC/PAN weight ratio and fiber diameter have been systematically investigated for the effects on the antibacterial performance of the NFMs. Sequentially, a quaternization treatment has been employed on the NFMs with an optimal fibrous structure to enhance the antibacterial ability. The resulting quaternized NFMs have demonstrated the great biocidal effects against Gram-positive and Gram-negative bacteria. Moreover, the excellent biocompatibility of the quaternized NFMs have also been thoroughly evaluated and verified.

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“…and S. aureus . Compared with probe 51 , a mixed-charge AIE polycarbonates probe ( 52 ) allowed for the rapid and selective imaging of S. aureus but not E. coli [ 122 ].…”

Section: Nonspecific Sites Identify Pathogensmentioning

confidence: 99%

Recent Progress in Identifying Bacteria with Fluorescent Probes

Wang

et al. 2022

Molecules

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The development of new techniques to rapidly and accurately detect bacteria has drawn continuous attention due to the potential threats posed by bacteria to human health and safety. Recently, a novel strategy based on fluorescent probes has drawn considerable interest for the detection of bacteria due to its high selectivity, fast response, and simple operation. In this review, we summarize the recent progress on fluorescent probes for the specific recognition and discrimination of Gram-negative and Gram-positive bacteria. In particular, we outline current design strategies, such as targeting of the differences in surface components, cell wall components, endogenous enzymes, surface charge, and hydrophobicity of various kinds of bacteria to develop various fluorescent sensors (organic small-molecule fluorescent probes, nanoprobes, and metal ion probes). We also emphasize the application of organic molecules in probe recognition elements. We hope that this review can stimulate this research area in bacterial detection and imaging in the future.

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Antibacterial AIE polycarbonates endowed with selective imaging capabilities by adjusting the electrostaticity of the mixed-charge backbone

Cited by 8 publications

References 52 publications

Smart aggregation‐induced emission polymers: Preparation, properties and bio‐applications

Smart aggregation‐induced emission polymers: Preparation, properties and bio‐applications

Preparation of CO₂‐Based Cationic Polycarbonate/Polyacrylonitrile Nanofibers with an Optimal Fibrous Microstructure for Antibacterial Applications

Recent Progress in Identifying Bacteria with Fluorescent Probes

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Antibacterial AIE polycarbonates endowed with selective imaging capabilities by adjusting the electrostaticity of the mixed-charge backbone

Cited by 8 publications

References 52 publications

Smart aggregation‐induced emission polymers: Preparation, properties and bio‐applications

Smart aggregation‐induced emission polymers: Preparation, properties and bio‐applications

Preparation of CO2‐Based Cationic Polycarbonate/Polyacrylonitrile Nanofibers with an Optimal Fibrous Microstructure for Antibacterial Applications

Recent Progress in Identifying Bacteria with Fluorescent Probes

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Preparation of CO₂‐Based Cationic Polycarbonate/Polyacrylonitrile Nanofibers with an Optimal Fibrous Microstructure for Antibacterial Applications