Antibacterial and anti-inflammatory ultrahigh molecular weight polyethylene/tea polyphenol blends for artificial joint applications

Ren, Yue; Wang, Feiyu; Chen, Zijian; Lan, Ri-Tong; Huang, Ru; Fu, Wan-Qun; Gul, Rizwan M.; Wang, Jing; Xu, Jia‐Zhuang; Li, Zhong‐Ming

doi:10.1039/d0tb01677b

Cited by 31 publications

(11 citation statements)

References 56 publications

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“…The antibacterial effects of CS, Al 3+ , and TP on P-0.2T-0.2C-0.08Al hydrogel were synergistic. The −NH 3+ and Al 3+ can disturb the cell membranes of bacteria via electrostatic adherence and thus interfere with cellular functions. , TP can also directly bind to cell membranes and damage their structures by producing excess intracellular reactive oxygen species. , Besides, studies have demonstrated that the combination of antibacterial agents and metal ions could improve their antibacterial activities . The inhibition zone diameter of P-0.2T-0.2C-0.08Al further proved its exceptional antibacterial activity (Figure c,d and SI Figure S16).…”

Section: Resultsmentioning

confidence: 84%

“…29,54 TP can also directly bind to cell membranes and damage their structures by producing excess intracellular reactive oxygen species. 55,56 Besides, studies have demonstrated that the combination of antibacterial agents and metal ions could improve their antibacterial activities. 57 The inhibition zone diameter of P-0.2T-0.2C-0.08Al further proved its exceptional antibacterial activity (Figure 4c,d and SI Figure S16).…”

Section: Mechanical Properties Of Hydrogelsmentioning

confidence: 99%

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Nature-Inspired Hydrogel Network for Efficient Tissue-Specific Underwater Adhesive

Chen

Guo

Mensah

et al. 2021

ACS Appl. Mater. Interfaces

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Underwater adhesives with efficient, selective, and repeatable adhesion are urgently needed for biomedical applications. Catechol-containing hydrogel adhesives have aroused much interest, but the design of specific underwater adhesives to biotic surfaces is still a challenge. Here we report a facile way that recapitulates the adhesion mechanism of mussel and sea gooseberry for the development of robust and specific hydrogel adhesives. With an exquisite design of chemical bonding, catechol chemistry, and electrostatic interaction, the hydrogel consisting of poly(acrylic acid) grafted with N-hydroxysuccinimide ester (PAA-NHS ester), tea polyphenol (TP), chitosan (CS), and Al 3+ exhibited fast, specific, and repeatable underwater adhesion to various biological tissues, such as porcine skin, intestine, liver, and shrimp. Furthermore, nanofibers-hydrogel composite (NF-HG) was prepared via the wicking effect of curcumin-loaded electrospun nanofibers. The NF-HG exhibited pH-responsive color changing properties, sustained drug release, and good cell viability, which made it suitable as a novel wound healing material. This strategy may provide great inspiration for designing multifunctional specific underwater adhesives.

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Section: Resultsmentioning

confidence: 84%

Section: Mechanical Properties Of Hydrogelsmentioning

confidence: 99%

Nature-Inspired Hydrogel Network for Efficient Tissue-Specific Underwater Adhesive

Chen

Guo

Mensah

et al. 2021

ACS Appl. Mater. Interfaces

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“…On this basis, alginate microgel is prepared to encapsulate GTPs, which could effectively kill S. aureus and promote the proliferation and differentiation of osteoblasts. Ren et al (2020) prepared an ultrahigh molecular weight polyethylene (UHMWPE) implant with strong antibacterial properties by mixing TPs, which greatly reduced periprosthetic joint infection and improved the success rate of joint replacement surgery. Furthermore, it is suggested that TPs blend UHMWPE is expected to become a multi-functional prosthesis for joint replacement to meet the needs of patients.…”

Section: Application In Medicinementioning

confidence: 99%

Molecular mechanisms and applications of tea polyphenols: A narrative review

et al. 2021

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Tea not only has a beloved taste, but also has rich biological activity, so it has become one of the best-selling beverages in the world. In the existing studies on tea, it is found that TPs account for highest proportion, which is the main bioactive ingredient. Generally, green tea polyphenols (GTP S ) are the main research materials, which are high in catechins. GTP S have significant health benefits (Xing et al., 2019) and are considered to be safe by the US Food and Drug Administration (Chang et al., 2019). Since the 1950s, scholars have begun to study the biological activity of TPs and their mechanism of action, and found that TPs are not only beneficial to human health, but also have an impact on food, medical, chemical and other fields.According to the research on the components of TPs (Khan & Mukhtar, 2018;Li et al., 2019), it is found that TPs contain catechins, flavonoids, anthocyanins, phenolic acids and other substances, among which catechins account for the largest proportion, up to 60%-80%. Catechin is divided into epicatechin (EC), epicatechin gallate (ECG), epigallocatechin (EGC) and epigallocatechin gallate (EGCG; the molecular structure is shown in the Figure 1). The content relationship is EGCG > EGC > ECG > EC, of which EGCG accounts for about 70%. Therefore, EGCG is the main catechin and the research on the biological activity of TPs mainly starts from EGCG.The research conclude that TPs can exert a variety of biological activities such as anti-oxidation, anti-tumor, anti-inflammation,

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“…This can be achieved through diverse chemical and enzymatic grafting methods. Commonly used antibacterial chemicals can be classified into several groups, including phenolic compounds (tannic acid, tea polyphenol , ), an N -halamine compound, , and diverse amino compounds such as chitosan, , chitosan oligosaccharides, poly l -lysine, and lactoferrin . These reactive chemicals operate via coupling with the residue groups such as serine, tyrosine, and lysine in silk fibroin chains, endowing SF with outstanding antibacterial effects.…”

Section: Introductionmentioning

confidence: 99%

Construction of a Rapid Photothermal Antibacterial Silk Fabric via QCS-Guided In Situ Deposition of CuSNPs

Ren

Yan

Wang

et al. 2022

ACS Sustainable Chem. Eng.

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Natural textiles provide an ideal environment for bacterial growth, causing harm to human health. In order to overcome this issue, a photothermal antibacterial technique has been employed as a facile strategy in recent years. Copper sulfide nanoparticles (CuSNPs) exhibit a satisfactory photothermal effect and can be potentially used to construct antibacterial textiles. Herein, we prepared a photothermal antibacterial silk fabric via a two-step method, where a chitosan quaternary ammonium salt (QCS) was used as a template to temporarily fix negative sulfur ions, which were transferred to silk fibers containing copper ammonia ions. The morphology, structure, and corresponding antibacterial ability for the obtained CuSNP-deposited silk fabric were examined. The obtained results revealed that the prepared materials, formed by interactions with silk fibers and QCS chains, exhibited uniform size and typical structural characteristics, promoting UV resistance and a good light-to-heat conversion effect. Moreover, a rapid antibacterial efficiency of the composite silk fabric was determined under light irradiation (400 mW/cm2), resulting in 99.99% bacteria death of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) within 5 min of irradiation. Additionally, the antibacterial rate of CuSNP-deposited with QCS as a template (SF/QCS/CuS) remained at a high level even after 10 washes, indicating a rapid bonding rate of the photothermal nanoparticles. This work develops a novel and efficient strategy for the construction of a photothermal antibacterial silk fabric, which expands its wide applications in the field of antibacterial materials.

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Antibacterial and anti-inflammatory ultrahigh molecular weight polyethylene/tea polyphenol blends for artificial joint applications

Abstract: Periprosthetic joint infection (PJI) is one of the main causes for the failure of joint arthroplasty. In view of the limited clinical effect of oral/injectable antibiotics and the drug resistance...

Cited by 31 publications

References 56 publications

Nature-Inspired Hydrogel Network for Efficient Tissue-Specific Underwater Adhesive

Nature-Inspired Hydrogel Network for Efficient Tissue-Specific Underwater Adhesive

Molecular mechanisms and applications of tea polyphenols: A narrative review

Construction of a Rapid Photothermal Antibacterial Silk Fabric via QCS-Guided In Situ Deposition of CuSNPs

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