Antibacterial and Anti-Quorum Sensing Molecular Composition Derived from Quercus cortex (Oak bark) Extract

Deryabin, D. G.; Tolmacheva, A. A.

doi:10.3390/molecules200917093

Cited by 62 publications

(42 citation statements)

References 35 publications

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“…The high content in tannins is responsible for the antidiarrheal properties (Reichling et al, 2008). Oak bark extracts furthermore possess antibacterial and anti-quorum sensing activities (Deryabin and Tolmacheva, 2015).…”

Section: Chamomile Flowers (Matricaria Chamomilla L Matricariae Flos)mentioning

confidence: 99%

Ethnoveterinary knowledge of farmers in bilingual regions of Switzerland – is there potential to extend veterinary options to reduce antimicrobial use?

Mertenat

Cero

Vogl

et al. 2020

Journal of Ethnopharmacology

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A B S T R A C TEthnopharmacological relevance: In the pre-antibiotic era, a broad spectrum of medicinal plants was used to treat livestock. This knowledge was neglected in European veterinary medicine for decades but kept alive by farmers. Emergence of multidrug resistant bacterial strains requires a severely restricted use of antibiotics in veterinary medicine. We conducted a survey on the ethnoveterinary knowledge of farmers in the bilingual (French and German speaking) Western region of Switzerland, namely the cantons of Fribourg, Neuchâtel and Jura, and in the French speaking part of the canton of Bern. Aim of the study: To find out whether differences exist in plants used by farmers in French speaking and bilingual regions of Switzerland as compared to our earlier studies conducted in Switzerland. Additional focus was on plants that are used in diseases which commonly are treated with antimicrobials, on plants used in skin afflictions, and on plants used in animal species such as horses, for which the range of veterinary medicinal products is limited. Material and methods: We conducted in 2015 semistructured interviews with 62 dialog partners, mainly cattle keeping farmers but also 18 horse keeping farmers. Of these, 41 were native French (FNS) and 21 native German speakers (GNS). Detailed information about homemade herbal remedies (plant species, plant part, manufacturing process) and the corresponding use reports (target animal species, category of use, route of administration, dosage, source of knowledge, frequency of use, last time of use and farmers satisfaction) were collected. Results: A total of 345 homemade remedies were reported, of which 240 contained only one plant species (Homemade Single Species Herbal Remedy Reports; HSHR). A total of 289 use reports (UR) were mentioned for the 240 HSHR, and they comprised 77 plant species belonging to 41 botanical families. Of these, 35 plant species were solely reported from FNS, 20 from GNS, and 22 from both. Taking into account earlier ethnoveterinary studies conducted in Switzerland only 10 (FNS) and 6 (GNS) plant species connected with 7% of FNS and GNS UR respectively were "unique" to the respective language group.The majority of the UR (219) was for treatment of cattle, while 38 UR were intended to treat horses. The most UR were for treatment of gastrointestinal and skin diseases. The most frequently mentioned plants were Linum usitatissimum L., Coffea L., Matricaria chamomilla L., Camellia sinensis (L.) Kuntze, and Quercus robur L. for gastrointestinal diseases, and Calendula officinalis L., Hypericum perforatum L. and Sanicula europaea L. for skin afflictions. Conclusion: No clear differences were found between the medicinal plants used by French native speakers and German native speakers. Several of the reported plants seem to be justified to widen the spectrum of veterinary T therapeutic options in gastrointestinal and dermatological disorders in cattle and horses, and to reduce, at least to a certain degree, the need for antibiotic treatments. Our...

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Section: Chamomile Flowers (Matricaria Chamomilla L Matricariae Flos)mentioning

confidence: 99%

Ethnoveterinary knowledge of farmers in bilingual regions of Switzerland – is there potential to extend veterinary options to reduce antimicrobial use?

Mertenat

Cero

Vogl

et al. 2020

Journal of Ethnopharmacology

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“…It is reported that gram-positive bacteria are more sensitive to plant-based extracts rich in tannin-like substances [28,29]. It is also confirmed by properties of compounds earlier found in Quercus cortex extract [12,13].…”

Section: Weigh (G) Dynamics In Crossmentioning

confidence: 55%

“…One of obstacles for use of phytogenic compounds is instable chemical composition of plant extracts depending on growing conditions, ecosystem, and other factors. Earlier, several compounds from oak bark extract (Quercus cortex) having both antibacterial and anti-QS activity [12,13] was found. These substances were used in tests on agricultural poultry.…”

Section: Introductionmentioning

confidence: 99%

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Mixtures of Biologically Active Substances of Oak Bark Extracts Change Immunological and Productive Indicators of Broilers

Фисинин¹,

Ushakov²,

Дускаев³

et al. 2018

S-h. biol.

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A b s t r a c tTo date, numerous studies are focused on searching for alternatives to antibiotics with similar antimicrobial and growth-stimulating effects that do not cause bacterial resistance and potential side effects for animals. Promising phytogenic compounds have been also recognized as potential alternatives to antibiotics in feeds. One of the problems of phytogenic compound use is the unstable chemical composition of plant extracts, depending on the conditions of growth, distribution area and other factors, so the question arises of extracting some substances with the known properties or designing their compositions. In this paper, it has been shown for the first time that a dietary composition of biologically active substances of Quercus cortex helps to maintain productivity and improves the immunomodulating state of Smena 8 poultry cross broilers. In our experiment, a composition of substances (CS) extracted from Quercus cortex and chemically synthesized («Acros Organics B.V.B.A.», Belgium) was used, including 2-n-propylresorcinol (98 %, AVH27024); 4-hydroxy-3methoxybenzaldehyde (99 %, AC14082-1000); 7-hydroxycoumarin (99 %, AC12111-0250); 3,4,5trimethoxyphenol (98.5 %, AC18914-0050); scopoletin (95 %, AC30290-0010); coniferyl alcohol (98 %, AL22373-5) with a confirmed anti-QS effect. A total of 120 broiler chickens aged 7 days were divided into 4 groups (n = 30) by analogue method. Control group was fed with the basic diet (BD). BD + CS 1 (1 ml/kg of live weight), BD + CS 2 (2 ml/kg of lw), and BD + CS 3 (3 ml/kg lw) were used for group 1, group 2, and group 3, respectively. In the experimental groups, as compared to the control, the number of blood leukocytes increased by 19.2-28.5 % (P  0.05), blood lymphocytes were higher by 24.4, 36.2 % (P  0.05) and 44.0 % (P  0.05), blood monocytes were higher by 23.5, 23.5 and 29.4 % (Р  0.05), and blood granulocyte counts were higher by 12.3 % (Р  0.05), 5.7 and 9.5 %. The blood ALT activity in the group 2 and group 3 exceeded the control value by 13.2 % (P  0.05). The level of GGT tended to decrease in the group 2 and group 3, along with a significant decrease in LDH by 17.6-22.5 % (P  0.05). The intake of the CS as a feed additive was accompanied by an increase in blood SOD levels in the test groups, the highest concentration being observed in the group 1 (95.3 %). The catalase indices had similar patterns. Dietary composition of biologically active substances promoted a 16.4 % increase (P  0.05) in blood -lysine levels in the group 1. Within 4 weeks, the dietary CSs led to an increase in the live weight of the poultry of the group 2 and groups 3 by 12.6-15.0 % (P  0.05) when compared to the group 1. In the group 1, the birds grew more rapidly with a 100 % survival rate of the herd, in contrast to the remaining groups with the survival index of 71 to 85 %. These contributed to an insignificant increase in the bird live weight at the end of the experiment (day 42) by 1.9 % (P  0.05) compared to the control group. Thus, feeding broiler chickens with...

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“…Кроме того, лекарственные растения являются ингибиторами системы чувствительности кворума (QS) у бактерий [10]. Такие ингибиторы обнаружены в экстракте коры Quercus [9]. В то же время известно, что экзогенные ферменты не только повышают продуктивность сельскохозяйственных животных, но и способствуют развитию бактериальной флоры в желудочно-кишечном тракте и тем самым косвенно влияют на популяцию бактерий [3,11].…”

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Assessment of the action of plant extract together with fine particles, as a condition for potentiation of scar processes

Miroshnikov¹,

Atlanderova²,

Makaeva³

2019

Agrarian Food Innov

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Antibacterial and Anti-Quorum Sensing Molecular Composition Derived from Quercus cortex (Oak bark) Extract

Cited by 62 publications

References 35 publications

Ethnoveterinary knowledge of farmers in bilingual regions of Switzerland – is there potential to extend veterinary options to reduce antimicrobial use?

Ethnoveterinary knowledge of farmers in bilingual regions of Switzerland – is there potential to extend veterinary options to reduce antimicrobial use?

Mixtures of Biologically Active Substances of Oak Bark Extracts Change Immunological and Productive Indicators of Broilers

Assessment of the action of plant extract together with fine particles, as a condition for potentiation of scar processes

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