Antibacterial and Antibiofilm Effect of Low Viscosity Chitosan against<i>Staphylococcus epidermidis</i>

Dragland, Inger Sofie; Valen, Håkon; Stenhagen, Ida S. R.; Lönn‐Stensrud, Jessica; Kopperud, Hilde Molvig

doi:10.1155/2016/9159761

Cited by 21 publications

(12 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, C6–OH and C2–NH 2 groups are more likely to introduce other groups to chitosan derivatives to improve the physical and chemical properties [ 34 ]. The antimicrobial effect of chitosan and chitosan derivatives was observed in a multitude of research [ 35 , 36 , 37 ]. When chitosan is dissolved, the amino groups (–NH 2 ) of glucosamine units are protonated to –NH 3 + .…”

Section: General Properties Of Chitosanmentioning

confidence: 99%

Antimicrobial Properties of Chitosan and Chitosan Derivatives in the Treatment of Enteric Infections

et al. 2021

View full text Add to dashboard Cite

Antibiotics played an important role in controlling the development of enteric infection. However, the emergence of antibiotic resistance and gut dysbiosis led to a growing interest in the use of natural antimicrobial agents as alternatives for therapy and disinfection. Chitosan is a nontoxic natural antimicrobial polymer and is approved by GRAS (Generally Recognized as Safe by the United States Food and Drug Administration). Chitosan and chitosan derivatives can kill microbes by neutralizing negative charges on the microbial surface. Besides, chemical modifications give chitosan derivatives better water solubility and antimicrobial property. This review gives an overview of the preparation of chitosan, its derivatives, and the conjugates with other polymers and nanoparticles with better antimicrobial properties, explains the direct and indirect mechanisms of action of chitosan, and summarizes current treatment for enteric infections as well as the role of chitosan and chitosan derivatives in the antimicrobial agents in enteric infections. Finally, we suggested future directions for further research to improve the treatment of enteric infections and to develop more useful chitosan derivatives and conjugates.

show abstract

Section: General Properties Of Chitosanmentioning

confidence: 99%

Antimicrobial Properties of Chitosan and Chitosan Derivatives in the Treatment of Enteric Infections

et al. 2021

View full text Add to dashboard Cite

show abstract

“…[35][36][37] Chitosan had also shown anti-biofilm activity, particularly against biofilm of S. aureus, P. aeruginosa and E. coli when added to a media or coated on a polystyrene surface. 38 The biofilm inhibition of chitosan is associated with the electrostatic interaction of positively charged amino groups of chitosan with the negatively charged groups on the bacterial surface, 39 leading to the disruption of cell wall integrity and permeability. 40 The biofilm inhibitory efficiency of chitosan varies for different species of bacteria because of the differences in cell wall structure and expression of surface molecule.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Biosynthesized silver nanoparticles loaded in gelatine hydrogel for a natural antibacterial and anti-biofilm wound dressing

Katas

Akhmar

Abdalla

2021

Journal of Bioactive and Compatible Polymers

View full text Add to dashboard Cite

Antibiotic-resistance and bacterial bioburden are the threats to wound healing. Nanoparticles are a revolutionary advancement in nanomedicine owing to their antibacterial properties, to be used as a promising alternative to antibiotics. A wound dressing with antibacterial and anti-biofilm effects may be a plausible strategy in curbing wound exacerbation caused by bacterial infection. Silver nanoparticles (AgNPs) are known for their excellent antibacterial activity. In present study, biosynthesized AgNPs using spent mushroom substrate (SMS) as reducing agent while chitosan as stabilizing agent were successfully produced. The nanoparticles exhibited considerable antibacterial and anti-biofilm activities with higher sensitivity towards Gram-negative bacteria. These AgNPs were later incorporated into genipin-crosslinked gelatine hydrogels as a wound dressing. The hydrogels were characterized for their physical, rheological and swelling properties, besides in vitro release of AgNPs. The formulated hydrogels demonstrated an adequate release of the AgNPs with acceptable physical, rheological and swelling properties, suitable as a vehicle for wound drug delivery. The antibacterial and anti-biofilm of the hydrogels against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli were effective in inhibiting the growth of the selected bacteria with minimum inhibitory concentration (MIC) of 63 μg/mL. In summary, genipin-crosslinked gelatine hydrogels loaded with the AgNPs are a promising anti-microbial wound dressing, a potential strategy for combating biofilm of wound infections and accelerating healing.

show abstract

“…Chitosan incorporation in bioglass, has been shown to increase remineralisation of enamel whit spot lesions by acting as a vehicle for the released ions from the bioglass [21]. When used as a coating on polystyrene, dental implants and poly(methylmethacrylate) surfaces, chitosan has been shown to reduce biofilm formation [22][23][24] High diversity of microbes in both primary and secondary endodontic infections is reported [25,26]. The antibacterial effect of ZOE materials incorporated with CH or COS was assessed using three different bacterial species.…”

Section: Introductionmentioning

confidence: 99%

Investigation on the antimicrobial activity of chitosan-modified zinc oxide-eugenol cement

Dragland

Wellendorf

Kopperud

et al. 2019

Biomaterial Investigations in Dentistry

Self Cite

View full text Add to dashboard Cite

Introduction: Coronal leakage and reinfection after root canal therapy is an important reason for endodontic failure. Zinc oxide-eugenol (ZOE) -based materials are often used as a coronal seal to prevent secondary infection. The antibacterial effect of ZOE cement is mainly due to leaching of eugenol from the material, but the effect is reported to decrease over time. Chitosan (CH) is a natural polymer with antibacterial properties. The aim of the study was to investigate if incorporation of (CH) and chitosan oligosaccharide (COS) in a ZOE-based material improved both the immediate and sustained antibacterial properties of the material. Methods: Enterococcus faecalis, Streptococcus mutans and Staphylococcus epidermidis was used to investigate the antibacterial effect of the materials in a modified direct contact test (MDCT) immediately after setting and after storage for 18 weeks in water. Leaching per week of eugenol from the materials was quantified using gas chromatography-mass spectrometry (GC-MS). The effect of eugenol on growth of bacteria was measured by reading of optical density at 600 nm after 18 h growth. Mechanical properties were investigated in a compressive strength test according to ISO 3107. Results: The present study showed that a ZOE-based material has antibacterial activity both as freshly prepared and after immersion in water for 18 weeks. Incorporating CH or COS may increase the antibacterial effect depending on the bacterial species investigated. The amount of leached eugenol did not differ between materials or during or after storage. S. mutans showed the highest susceptibility to eugenol of the three species investigated. Modification of the materials with CH or COS reduced the compressive strength, but the requirements in ISO 3017 were still met.

show abstract

Antibacterial and Antibiofilm Effect of Low Viscosity Chitosan againstStaphylococcus epidermidis

Cited by 21 publications

References 37 publications

Antimicrobial Properties of Chitosan and Chitosan Derivatives in the Treatment of Enteric Infections

Antimicrobial Properties of Chitosan and Chitosan Derivatives in the Treatment of Enteric Infections

Biosynthesized silver nanoparticles loaded in gelatine hydrogel for a natural antibacterial and anti-biofilm wound dressing

Investigation on the antimicrobial activity of chitosan-modified zinc oxide-eugenol cement

Contact Info

Product

Resources

About