Antibacterial and Antifungal Activities of Leaf Extract of Morinda elliptica

Abstract

This work was designed to evaluate the antimicrobial potential of Morinda elliptica by determining the zone of growth inhibition of the leaf extract against selected bacterial and fungal strains. Antifungal and antibacterial properties of the extract at different concentrations (25, 50, 100, 250 and 500 μg/ml) were investigated after successive maceration in four solvents in order of increasing polarity [hexane (180 g), dichloromethane (342 g), ethyl acetate (471 g), and methanol (384)]. The agar disc diffusion method was used against selected human bacteria Escherichia coli, Salmonella typhii, Staphylococcus aureus, and the antifungal activity of the extract against Aspergillus brasiliences and A. flavus. Zones of growth inhibition of the extract were then compared with the standard antibiotic chloramphenicol (500 μg/ml) for the antibacterial activity, and against nystatin (500 μg/ml) for antifungal activity. The result of the study showed a remarkable bactericidal activity of the plant extract against the test organisms E. coli (14.667 + 0.577) and S. typhii (13.667 + 0.577) with a weak activity against the growth of S. aureus as compared to standard (21.667 + 0.577) at 500 μg/ml. The result of the antifungal activity showed considerable activity of the plant extract against the growth of A. brasiliences (11 + 0.1000) and weak activity against the growth A. flavus at 500 μg/ml. The findings of the study indicated that the leaf extract of M. elliptica is a reservoir of bioactive compounds. The compounds can be useful in the development of new pharmaceutical products that can be effective against human pathogenic strains E. coli and S. typhii. This could serve as a lead for understanding a novel mechanism of action in future research activities.

Review on Anthraquinones Isolated from Rubiaceae Family

“…Compounds found in the species, damnacanthal and nordamnacanthal, developed active reactions against many cell lines and a high potential in developing anticancer agents (Ismail, 1999). A study on human pathogenic strains of E. coli and S. typhi showed effective results from M. elliptica leaf extract, indicating its potential in the development of new pharmaceutical products (Wakawa et al, 2022).…”

Antibacterial activity of methanol leaf extract and fruit decoction from Morinda persicifolia Buch. – Ham

“…Presently, there were some studies on antibacterial activity of Morinda methanol leaf extract. When conveyed antibacterial activities of leaf methanol extract of Morinda elliptica, Wakawa et al, [3] found that at 500 µg/ml, the extract was moderately active. Mean values of the zone of growth inhibition observed against E. coli and Staphylococcus aureus was of 10.667 mm and 10.333 mm, respectively.…”

“…The studies showed the plant extracts were against to E. coli and S. typhii and S. aureus. The Noni extract inhibited the growth of some fungi such as A. brasiliences and A. flavus [3]. Different extracts of M. tinctoria fruits revealed antimicrobial activity against the pathogens.…”

Antibacterial activity of ethanol extract from Morinda citrifolia L. leaves and fruits collected in Tan Hung district, Long An province, Vietnam

“…Presently, antimicrobial activity of M. elliptica leaves was reported by using agar disk diffusion method. The research showed that the extracts by n-hexane, dichloromethane, ethyl acetate, and methanol were inhibited against to E. coli and S. typhii and S. aureus and inhibited the growth of fungi A. brasiliences and A. flavus [7].…”