Antibacterial and Antifungal Activities of Ocimum Gratissimum L.

Abstract

The development of antibiotic resistance in microorganisms is a global challenge for the clinicians, pharmacist and research scientists leading to the development of new medicinal formulations that are effective and easily consumable. The plant yielding essential oil with chief constituent as eugenol has been identified as an important compound with strong inhibition of bacteria, and storage fungi. Ocimum gratissimum is an aromatic shrub occurring in warm tropical regions has been used in traditional medicine in India to cure various ailments in general and as an antimicrobial agent in particular. The literature surveyed reveals that the plant oil exhibit strong potentiality against gram negative and gram positive bacteria along with diverse human and plant fungi. As a natural product, the plant oil is safer as food preservatives and stored grain protectant and has wide application in cosmetics and perfumery industries. This comprehensive review is attempted to provide the valuable information on antimicrobial activities of the plant essential oil that will be used to explore and develop a standard therapeutics system for the management of clinical and multiple drug resistant microorganisms.

Mixed Non-Albicans Candida Fungemia: An Uncommon but Easily Overlooked Clinical Entity

“…Thus, the role of in vitro antifungal susceptibility testing is crucial, particularly so when faced with NAC species with unpredictable fluconazole susceptibility, as documented here. Perhaps, new sources or classes of antifungal agents need to be sought and evaluated for human use as well [12,13]. With regard to catheter removal, its role in the management of candidemia is especially imperative if it is the source of infection.…”

Ocimum Phytochemicals and Their Potential Impact on Human Health

“…The antibacterial and antifungal activities of Ocimum species have been studied on various bacteria and fungi [29,[94][95][96]. These studies indicate that essential oils are more efficient antifungals and antibacterials compared to the polar extracts [97][98][99].…”

Non-Neoformans Cryptococcemia in a Patient With Hodgkin’s Lymphoma

“…Other azoles (e.g., voriconazole) were also used successfully to treat infections caused by C. laurentii [10]. The recent discovery of new antifungal compounds from plants such as fenugreek and clove basil could also potentially expand the antifungal arsenal against C. laurentii [12,13].…”