Antibacterial and Antifungal Potentiality of Leaf Extract of &lt;i&gt;Phyllanthus &lt;/i&gt;&lt;i&gt;Fraternus&lt;/i&gt; Webster: An Ethnomedicinal Plant

Mehta, Kavit; N, Patel B.; K, Jain B.

doi:10.12691/ajmr-2-2-6

Cited by 5 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As previously mentioned, medicinal plants have antimicrobial activities [30]. Pomegranate fruits are rich in polyphenols, such as ellagitannins (ETs), mainly including α and β isomers of punicalagin (PC), gallic acid (GA), ellagic acid (EA) and its glycosylated derivatives, and anthocyanins.…”

Section: Discussionmentioning

confidence: 99%

Toxicological Evaluation of Pomegranate Fruit Extract in Male and Female Rats

El-Sheikh,

Barakat,

Rabiee

et al. 2024

Egyptian Journal of Veterinary Sciences

View full text Add to dashboard Cite

Omegranate (Punica granatum L.) fruit is often consumed as fresh fruit and juice. Its varied medicinal benefits in traditional medicine. The current study aimed to assess the acute and subacute toxicity profiles of pomegranate extract in male and female Sprague Dawley rats. In acute toxicity investigation, rats of both sexes were administered 1g/kg body weight of extract intraperitoneally. In the subacute toxicity trial, that was administered the extract (1g/kg body weight) intraperitoneally every 24 hours for 15 days, whereas the control group received distilled water. Daily food consumption and drink intake and rats' body weight changes were carefully recorded and documented for two weeks. Hematological measures of complete blood count (CBC), serum biochemical parameters of liver, heart, and kidney function, and lipid profile were evaluated to identify the principal harmful effects on tissues. There were no behavioral changes or mortality recorded in the treated groups. The LD50 value was greater than 1g/Kg body weight. There were no significant differences (p<0.05) in body weight gain, food, and water intake in groups. The hematological and biochemical parameters and the organ weights showed no significant alterations (p<0.05) between the treatment and control groups. Group 1, which received doses of 1 g/kg body weight of extract 2, exhibited superior outcomes in most of the parameters under investigation. This included improvements in behavior, food and water intake, average body weight, relative organ weights, and serum biochemical markers. The overall finding of this study reveals that pomegranate extract is safe up to 1g/Kg body weight intraperitoneal administration in male and female Sprague Dawley rats, and we conclude from prior results that pomegranate extract is safe.

show abstract

Section: Discussionmentioning

confidence: 99%

Toxicological Evaluation of Pomegranate Fruit Extract in Male and Female Rats

El-Sheikh,

Barakat,

Rabiee

et al. 2024

Egyptian Journal of Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…Fruits are also used in the treatment of ulcers, wounds, sores, scabies, ringworm and other skin problem. A decoction of root and leaves was used to treat malaria and antifungal activity against strains Aspergillus niger and Candida albicans [8] .…”

Section: Herbals As Antifungalmentioning

confidence: 99%

Herbals as Antimicrobials: A Review

Kumari¹,

Misra²,

Sharma³

2016

J. Ayu. Her. Med.

View full text Add to dashboard Cite

We herein outline some traditional plants, their phytochemicals and uses in emerging health problems arise through microorganism. Herbal remedies in the form of antibacterial and antifungal are prepared from a variety of plant parts such as leaves, stem, root, bark or fruit. Herbal dosage forms advocate enhancing the immunity against the diseases through its noble preparation originated from plants, used in the treatment of various infectious diseases caused by a microorganism. Some antifungal herbals i.e. Guava ( Psidium guajava), Orchid (Bauhinia purpurea), Turmeric (Curcuma longa), Neem (Azadirachta Indica), Pippali (Piper longum), Creeping cucumber (Solena amplexicaulis) and Amla (Embelica officinalis) are used to cure skin associated problems as itch, scabies, skin sores, wounds and dermatosis. Herbs as Hyacinth bean (Lablab purpureus), Purging nut (Jatropha curcas), Bitter melon (Momordica Charantia), Jangali palak (Rumex nepalensis) are extensively used in the treatment of a bacterial infection related with hookworm, chickenpox, chikungunya, cellutis, enterococcus infection, fasciolasis and Moniliasis or thrush.

show abstract

“…This plant is locally known as Hajarmani and Kanocha (Hindi language), and as herbal formulation named “Bhumyamlaki” [ 8 , 9 ]. This plant was known to be highly effective for treating different diseases such as hepatitis, cold, flu, tuberculosis, viral infections, anemia, biliary and urinary disorders and other bacterial and fungal infections [ 8 , 10 ]. This plant has the ability to act as antioxidant, antinociceptive, hepatoprotective, and antifibromyalgic [ [11] , [12] , [13] ].…”

Section: Introductionmentioning

confidence: 99%

Protective role of Phyllanthus fraternus in alloxan-induced diabetes in rats

Singh

Kaur

et al. 2020

Journal of Ayurveda and Integrative Medicine

View full text Add to dashboard Cite

Background Phyllanthus fraternus is a pantropical weed of family phyllanthaceae , mainly found in northeast India. It has been used in the folklore medicine of Manipur tribe for treating type 2 diabetes. Objective The present study was commenced to evaluate the anti-diabetic and renoprotective potential of P. fraternus (aerial parts) in alloxan-induced diabetes in rats. Materials and methods Alloxan (130 mg/kg, ip) was used for the induction of diabetes in adult male wistar rats. Animals with blood glucose level greater than 280 mg/dL were treated once daily for 14 days with various test extracts. The biochemical parameters were measured from serum on the 15th day post-treatment. Necropsy samples harvested from pancreas and kidneys were examined for histopathological changes in these organs. Results Alloxan-induced diabetes not only caused significant increases in blood glucose, triglycerides, total cholesterol, creatinine and urea levels, but also provoked high oxidative stress in pancreas and kidneys. Profound morphological injuries were observed in islets of Langerhans and kidneys of diabetic animals. Administration of methanol extract (200 and 400 mg/kg) and mother liquor (200 and 400 mg/kg) ameliorate the elevated levels of blood glucose, triglycerides, total cholesterol as well as other biochemical parameters, but highest reduction in blood glucose concentration was observed with the largest dose of ethyl acetate fraction (400 mg/kg) of P. fraternus . Histopathological examination of pancreas and kidneys also exhibited greater protection by treatment with acetate fraction (400 mg/kg). The HPLC analysis showed the presence of four polyphenols such as catechin, gallic acid, caffeic acid and ellagic acid in ethyl acetate fraction of P. fraternus during HPLC analysis. Conclusion The results suggest that polyphenols present in P. fraternus may be responsible for the anti-diabetic and renoprotective activity in rats. Such protective effects of could be mediated through flavonol-induced anti-oxidant and anti-inflammatory activities in the pancreas and kidneys.

show abstract

Antibacterial and Antifungal Potentiality of Leaf Extract of <i>Phyllanthus </i><i>Fraternus</i> Webster: An Ethnomedicinal Plant

Cited by 5 publications

References 7 publications

Toxicological Evaluation of Pomegranate Fruit Extract in Male and Female Rats

Toxicological Evaluation of Pomegranate Fruit Extract in Male and Female Rats

Herbals as Antimicrobials: A Review

Protective role of Phyllanthus fraternus in alloxan-induced diabetes in rats

Contact Info

Product

Resources

About