Antibacterial and antioxidant properties of biosynthesized zinc oxide nanoparticles from Ceropegia candelabrum L. – An endemic species

Murali, M.; Mahendra, C.; Nagabhushan,; Rajashekar, N.; Sudarshana, M. S.; Raveesha, K. A.; Amruthesh, K. N.

doi:10.1016/j.saa.2017.02.027

Cited by 126 publications

(45 citation statements)

References 21 publications

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“…(Figure 3). The results are in conformity with the outcomes of other investigators, where the absorption peak that was read between 400 to 600 cm −1 was designated as a metal oxide bond [22,40]. The morphology of the biosynthesized ZnO-NPs is given in Figure 4A.…”

Section: Characterization Of Biosynthesized Zno-npssupporting

confidence: 90%

“…The structural alteration of RBCs will eventually lead to functional loss, which ultimately causes oxidative stress [7]. The results affirm that the ZnO-NPs can help to prevent oxidative stress during the process of glycation as they are known to possess potent antioxidant properties [22].…”

Section: Protective Effect Of Zno-nps On Red Blood Corpusclesmentioning

confidence: 62%

“…ZnO-NPs were synthesized by the solution combustion method according to Murali et al [22] with minor modifications. Fresh leaves (30 g) of M. indica were collected and washed with running tap water and subsequently blended with a hand blender using 300 mL of sterile distilled water and filtered through Whatman No.…”

Section: Biosynthesis Of Zno-npsmentioning

confidence: 99%

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Biosynthesized ZnO-NPs from Morus indica Attenuates Methylglyoxal-Induced Protein Glycation and RBC Damage: In-Vitro, In-Vivo and Molecular Docking Study

et al. 2019

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The development of advanced glycation end-products (AGEs) inhibitors is considered to have therapeutic potential in diabetic complications inhibiting the loss of the biomolecular function. In the present study, zinc oxide nanoparticles (ZnO-NPs) were synthesized from aqueous leaf extract of Morus indica and were characterized by various techniques such as ultraviolet (UV)-Vis spectroscopy, Powder X-Ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy (FT-IR), Scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS). Further, the inhibition of AGEs formation after exposure to ZnO-NPs was investigated by in-vitro, in-vivo, and molecular docking studies. Biochemical and histopathological changes after exposure to ZnO-NPs were also studied in streptozotocin-induced diabetic rats. ZnO-NPs showed an absorption peak at 359 nm with a purity of 92.62% and ~6–12 nm in size, which is characteristic of nanoparticles. The images of SEM showed agglomeration of smaller ZnO-NPs and EDS authenticating that the synthesized nanoparticles were without impurities. The biosynthesized ZnO-NPs showed significant inhibition in the formation of AGEs. The particles were effective against methylglyoxal (MGO) mediated glycation of bovine serum albumin (BSA) by inhibiting the formation of AGEs, which was dose-dependent. Further, the presence of MGO resulted in complete damage of biconcave red blood corpuscles (RBCs) to an irregular shape, whereas the morphological changes were prevented when they were treated with ZnO-NPs leading to the prevention of complications caused due to glycation. The administration of ZnO-NPs (100 mg Kg−1) in streptozotocin(STZ)-induced diabetic rats reversed hyperglycemia and significantly improved hepatic enzymes level and renal functionality, also the histopathological studies revealed restoration of kidney and liver damage nearer to normal conditions. Molecular docking of BSA with ZnO-NPs confirms that masking of lysine and arginine residues is one of the possible mechanisms responsible for the potent antiglycation activity of ZnO-NPs. The findings strongly suggest scope for exploring the therapeutic potential of diabetes-related complications.

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Section: Characterization Of Biosynthesized Zno-npssupporting

confidence: 90%

Section: Protective Effect Of Zno-nps On Red Blood Corpusclesmentioning

confidence: 62%

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Biosynthesized ZnO-NPs from Morus indica Attenuates Methylglyoxal-Induced Protein Glycation and RBC Damage: In-Vitro, In-Vivo and Molecular Docking Study

et al. 2019

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“…Antibacterial and antifungal activity of ZnO NPs against various pathogenic microbes among humans and plants (bacteria and fungi) such as Bacillus subtilis, Salmonella sp., Staphylococcus aureus, Escherichia coli, Aspergillus flavus, and Aspergillus niger using well diffusion method has been reported by various researchers [7,8]. Some researchers have investigated the antioxidant activity of green synthesized ZnO NP from Ceropegia candelabrum L. [9], Polygala tenuifolia [10], Cassia fistula [11], and Eucalyptus globules [12]. Curcuma longa is a medicinal plant abundantly available in South India.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Analysis: The Antimicrobial and Antioxidant Activity of Zinc Oxide Nanoparticles From Curcuma Longa

Jacob

Periakaruppan

2019

Asian J Pharm Clin Res

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Objective: Curcuma longa is a known natural medicine for inflammation from ancient times. It has a low absorption rate and poor solubility. Hence, it is used for the green synthesis of nanoparticles. Zinc oxide nanoparticle (ZnO NPs) is famous nanoparticles which are economical, less toxic, and brilliantly biocompatible. They have potential biomedical properties, mainly anticancer, antidiabetic, and antimicrobial.Methods: The present study was designed to investigate in vitro analysis of the antimicrobial activity against pathogenic bacteria and fungi and its ability to scavenge reactive oxygen radicals of ZnO NPs.Results and Conclusion: The results indicated that ZnO NPs produced from C. longa had higher antimicrobial activity against Escherichia coli, Staphylococcus aureus, Streptococcus pyogenes, and Candida albicans. Therefore, we suggest that ZnO NPs can be used as the antimicrobial agent. It is a good scavenger of superoxide radical, nitric oxide, and hydrogen peroxide and has reducing power, which is greater than ascorbic acid at a higher concentration.

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“…The enthalpy of the nanoparticles causes the disruption of cell and the internal energy gradient between cell and nanoparticle might be one of the parameters for increased bactericide activity. The inhibition is also because of the interaction of noble metal and ZnO NPs with enzymes, DNA and cell membrane or the generated reactive oxygen species (ROS) that might misguide the transportation channels (21,22). *Values are expressed as mean ± SD (n=4).…”

Section: Fig 5 Tem Images Of Synthesized (A) Ag and (B) Znomentioning

confidence: 99%

Antibacterial and Anticancer Activities of Biogenic Synthesized Ag and ZNO NPS

Geetha*¹

2019

IJITEE

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Biogenic synthesis of Ag and ZnO nanoparticles has been proposed as an environmental friendly and cost effective method. Curcuma longa tuber extract was used to reduce silver nitrate and zinc acetate to Ag NPs and ZnO NPs. The extract acts as each reducing capping agent. Synthesis process be standardized by modifying various parameters like salt concentrations, C. longa tuber extract concentration, and temperature and incubation period. The formation of Silver and ZnO NPs was observed among color transition. The morphology of the amalgamate Ag and ZnO NPs be characterized with various experimental techniques (FESEM, TEM). The face-centered cuboidal structure of Ag and ZnO NPs be studied using X-ray optical phenomenon. Further Ag in addition to ZnO NPs were tested for antibacterial and anticancer activities.

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Antibacterial and antioxidant properties of biosynthesized zinc oxide nanoparticles from Ceropegia candelabrum L. – An endemic species

Cited by 126 publications

References 21 publications

Biosynthesized ZnO-NPs from Morus indica Attenuates Methylglyoxal-Induced Protein Glycation and RBC Damage: In-Vitro, In-Vivo and Molecular Docking Study

Biosynthesized ZnO-NPs from Morus indica Attenuates Methylglyoxal-Induced Protein Glycation and RBC Damage: In-Vitro, In-Vivo and Molecular Docking Study

In Vitro Analysis: The Antimicrobial and Antioxidant Activity of Zinc Oxide Nanoparticles From Curcuma Longa

Antibacterial and Anticancer Activities of Biogenic Synthesized Ag and ZNO NPS

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