Antibacterial and antitumor macrolides fromstreptomyces sp. Is9131

Zhao, Pei‐Ji; Fan, Li; Li, Guo Hong; Zhu, Na; Shen, Yue

doi:10.1007/bf02978203

Cited by 48 publications

(22 citation statements)

References 12 publications

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“…ls9131 of M. hookeri as previously reported (9), and its purity is >95%. The compound was dissolved in DMSO to the concentration of 0.1 mol/L (in vitro) or in ethanol (in vivo) before each assay and then diluted with normal saline.…”

Section: Methodssupporting

confidence: 52%

“…However, MFTZ-1 was cyclized to form a dimacrolide, and the substituent at C-8 ¶ was ethyl in this compound but methyl in dimeric nonactic acid. Dimeric nonactic acid did not show obvious antifungal or antibacterial activity; however, the dimeric dinactin showed strong antibacterial activity (9). Overall, it seems that the lactone ring may play an important role in these activities.…”

Section: Discussionmentioning

confidence: 86%

“…1A), a new derivative of nonactic and homononactic acids isolated from an endophyte Streptomyces sp. ls9131 of Magnolia hookeri, characterized to be a dimeric dinactin (9), stood out as a novel Topo II poison structurally distinct from all Topo II inhibitors known thus far. In the present study, we aimed to investigate the antitumor activities of MFTZ-1 both in vitro and in vivo and figure out the related possible mechanisms of action.…”

Section: Introductionmentioning

confidence: 99%

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MFTZ-1, an actinomycetes subspecies–derived antitumor macrolide, functions as a novel topoisomerase II poison

Xie

Zhu²,

Lin³

et al. 2007

Molecular Cancer Therapeutics

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5,13,19,10 ]eicosane-3,12-dione (MFTZ-1), a new macrolide compound isolated from Streptomyces sp. Is9131, displayed wide cytotoxicity in human tumor cell lines with an average IC 50 of 0.905 Mmol/L. Notably, MFTZ-1 showed significant cytotoxicity in the three multidrug resistance cell lines with an average resistance factor of 2.08. The in vivo experiments showed that MFTZ-1 had inhibitory effects on the human ovarian carcinoma HO-8910 cell line xenotransplanted in nude mice. Further studies showed that MFTZ-1 induced DNA double-strand breaks and triggered mitochondriadependent apoptosis in human leukemia HL-60 cells. Using a yeast genetic system, we found that topoisomerase (Topo) II rather than Topo I was the primary cellular target of MFTZ-1. Most importantly, MFTZ-1 functions as a novel nonintercalative Topo II poison via binding to ATPase of Topo II, characterized by its strong inhibition on the decatenation and relaxation of Topo II. The capacity of MFTZ-1 to stabilize Topo II -DNA covalent complexes was comparable with that of the classic Topo II poison, etoposide. Moreover, using a Topo II catalytic inhibitor aclarubicin and Topo II -deficient HL-60/MX2 cells, we further showed that MFTZ-1 -triggered DNA doublestrand breaks and apoptosis occurred in a Topo IIdependent manner. Together, the well-defined Topo IIpoisoning function and the potent antitumor activity, with the appreciable anti -multidrug resistance action in particular, promises MFTZ-1 as a novel potential Topo II -targeted agent, which merits further research and development.

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Section: Methodssupporting

confidence: 52%

Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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MFTZ-1, an actinomycetes subspecies–derived antitumor macrolide, functions as a novel topoisomerase II poison

Xie

Zhu²,

Lin³

et al. 2007

Molecular Cancer Therapeutics

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“…[1,2] In the course of our exploration for chemical constituents from the endophytic microorganisms of medicinal plants, a series of new compounds were isolated previously. [3][4][5][6][7] Camptotheca acuminate, a medicinal plant specifically distributed in China, is rich in the anticancer compound camptothecin, with the highest distribution in the new leaf of up to 0.4 %. In such a special living environment, special endophytic fungi may exist.…”

Section: Introductionmentioning

confidence: 99%

Secondary Metabolites of Phomopsis sp. XZ‐26, an Endophytic Fungus from Camptothecaacuminate

Lin

Chen

et al. 2009

Eur J Org Chem

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Eleven new metabolites, including nine lovastatin analogues [oblongolides N-V (1-2 and 5-11), which were defined as naphthalene-type fungal polyketides], one linear furanopolyketide (13) and a monoterpene named dihydroxysabinane (14), together with four known compounds including oblongolides B (3) and C (4), one linear furanopolyketide (12) and the sesterterpene terpestacin (15), were isolated from the endophytic fungal strain Phomopsis sp. XZ-26 of Camptotheca acuminate. Their structures were elucidated by spec-

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“…maytansine) from endophytic microorganisms residing in Maytenus hookeri (Celastraceae), has shown that the culture material of some Streptomyces sp. on M. hookeri contained compounds that exhibited potent activities against several pathogenic micro-organisms (Zhao et al 2005) and also had antineoplastic activity (Lu and Shen 2003).…”

Section: Introduction*mentioning

confidence: 99%

Tricycloalternarene derivatives produced by an endophyte Alternaria alternata isolated from Maytenus hookeri

Qiao

Lin

Gao

et al. 2007

J. Basic Microbiol.

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A new tricycloalternarene derivative, named tricycloalternarenal (1), together with three known compounds was isolated from the cultures of Alternaria alternata, an endophytic fungus in the leaves of the plant Maytenus hooker! (Celastraceae). Structure of 1 was established as (2E)-6-(3, 3a, 5, 6, 7, 8, 9, 9a-octahydro-5-hydroxy-3a-methyl-8-oxo-cyclo-penta[b]chromen-1-yl)-2-methylhept-2-enal by spectroscopic methods, including 2D-NMR experiments. The remaining compounds were determined as tricycloalternarene-3b (2), alterperylenol (3), and dihydroalterperylenol (4).

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Antibacterial and antitumor macrolides fromstreptomyces sp. Is9131

Cited by 48 publications

References 12 publications

MFTZ-1, an actinomycetes subspecies–derived antitumor macrolide, functions as a novel topoisomerase II poison

MFTZ-1, an actinomycetes subspecies–derived antitumor macrolide, functions as a novel topoisomerase II poison

Secondary Metabolites of Phomopsis sp. XZ‐26, an Endophytic Fungus from Camptothecaacuminate

Tricycloalternarene derivatives produced by an endophyte Alternaria alternata isolated from Maytenus hookeri

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