Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide

Vaijayanthi, S. Parimala; Mathiyalagan, N.

doi:10.18052/www.scipress.com/ilcpa.26.1

Cited by 11 publications

(15 citation statements)

References 15 publications

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“…Literature survey showed that when both hydrogen and chloride ions were found to catalyze the reactions involving N-halo compounds, molecular chlorine was assumed to act as the effective oxidant and such reports were given in the oxidation of chalcones [17] and aminoacids [18]. At the lower pH, molecular chlorine is the much more reactive species than hypochlorous acid [19].…”

Section: Resultsmentioning

confidence: 99%

Reactions of enolisable ketones with dichloroisocyanuric acid in absence and presence of added chloride ions – a kinetic study

Kumar¹,

Nadh²

2015

Bull. Chem. Soc. Eth.

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ABSTRACT. Kinetics of reactions of enolisable ketones (S = acetone/2-butanone) with dichloroisocyanuric acid (DCICA) were studied in aqueous acetic acid and perchloric acid media in absence and presence of added chloride ions. The reactions were found to be pseudo zero order and pseudo first order on [DCICA] in absence and presence of chloride ions respectively. Both in presence and absence of chloride ions, first order and fractional order in substrate and perchloric acid were observed respectively. An increase in the rate of reaction was observed with an increase in chloride ion concentration as well as acetic acid composition. The results were interpreted in terms of probable mechanisms involving (i) rate-determining enol formation from the conjugate acid of the ketone (SH + ) in the absence of added chloride ions and (ii) rate-determining interaction of SH + with the most effective molecular chlorine species produced by the hydrolysis of DCICA (rather than a rate-determining interaction of enol with chlorine) in the presence of added chloride ions, prior to the rapid steps of product formation.

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Section: Resultsmentioning

confidence: 99%

Reactions of enolisable ketones with dichloroisocyanuric acid in absence and presence of added chloride ions – a kinetic study

Kumar¹,

Nadh²

2015

Bull. Chem. Soc. Eth.

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“…Amino acids were purchased from Merck and used as such. N-chloropyrazinamide 23 was prepared by chlorinating pyrazinamide using trichloroisocyanuric acid (TCICA). Standard solution of NCPZA was prepared afresh.…”

Section: Methodsmentioning

confidence: 99%

“…Although a lot of works have been reported on the oxidation of amino acids by N-halo compounds [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] , the kinetic investigation on the oxidation of amino acids by N-chloropyrazinamide, a newly synthesized oxidant 23 , is not reported so far. Hence, in the present investigation, the kinetics of oxidation of alanine (Ala), glycine (Gly), leucine (Leu), phenyl alanine (Phe) and valine (Val) with N-chloropyrazinamide (NCPZA) in aqueous acetic acid medium in the presence of perchloric acid has been reported 26 .…”

Section: Introductionmentioning

confidence: 99%

Kinetics of Oxidation of Amino Acids by a Newly Synthesized Oxidant, N-Chloropyrazinamide in Aqueous Acetic Acid Medium

Vaijayanthi¹,

Mathiyalagan²

2013

ILCPA

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The kinetics of oxidation of amino acids namely, alanine, glycine, leucine, phenyl alanine and valine by N-chloropyrazinamide (NCPZA) in aqueous acetic acid medium in the presence of hydrochloric acid have been investigated. The observed rate of oxidation is first order in [NCPZA], [H + ] and [Clˉ]. The order with respect to [amino acid] is zero. The rate of oxidation increases with increase in the percentage of acetic acid. The reaction rate increases slightly with increase in ionic strength, while retards with addition of pyrazinamide. Arrhenius and thermodynamic activation parameters have been evaluated from Arrhenius plot by studying the reaction at different temperatures. A most probable reaction mechanism has been proposed and an appropriate rate law is deduced to account for the observed kinetic data.

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“…[1,2] In recent development NCS has been extensively employed as an oxidant for a variety of organic substrates, [3] chalcones, [4] 2-hydroxy propanoic acid [5] (in alkaline medium) 9-telluraheptadecanoic acid, [6] alcohols, [7] benzyl phenyl ether [8] etc.…”

Section: Introductionmentioning

confidence: 99%

Phosphotungustic Acid Catalysed Oxidation of Aliphatic Hydroxy Acids by N-chlorosuccinimide in Aqueous Acetic Medium

2018

International Journal of Advanced Research in Chemical Science

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Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide

Cited by 11 publications

References 15 publications

Reactions of enolisable ketones with dichloroisocyanuric acid in absence and presence of added chloride ions – a kinetic study

Reactions of enolisable ketones with dichloroisocyanuric acid in absence and presence of added chloride ions – a kinetic study

Kinetics of Oxidation of Amino Acids by a Newly Synthesized Oxidant, N-Chloropyrazinamide in Aqueous Acetic Acid Medium

Phosphotungustic Acid Catalysed Oxidation of Aliphatic Hydroxy Acids by N-chlorosuccinimide in Aqueous Acetic Medium

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