Antibacterial Behavior of Pyridinecarboxylatesilver(I) Complexes

Abstract

FT-IR spectroscopy of carboxylic groups and viability tests were useful to understand the antibacterial properties of six highly efficient silver(I) pyridinecarboxylate (nicotinic, picolinic and isonicotinic acids) and bipiridinecarboxylate (pyridine-2,3-dicarboxylic, pyridine-2,4-dicarboxylic and pyridine-2,5-dicarboxylic acids) complexes with Ag-O and Ag-N bonds against E. coli (ATCC 25922) and Streptococcus agalactiae (ISP 329-09). The results show a tendency between the nature of Ag-X (X＝oxygen and nitrogen) bonds and the rate or efficiency of antibacterial behavior.

Stability of Antibacterial Silver Carboxylate Complexes against Staphylococcus epidermidis and Their Cytotoxic Effects

“…In the upper right image ( Figure 6 c), contamination of E. coli was observed, which appears to be more sensitive to wall rupture and condensation of cytoplasmic material than is S. epidermidis . This concurs with the results of other viability studies [ 24 , 25 , 26 , 27 ], which have shown higher mortality rates for E. coli .…”

Ag(I) and Zn(II) isonicotinate complexes: design, characterization, antimicrobial effect, and CT-DNA binding studies

“…Ag(I) pyridinecarboxylates are extensively studied as prospective antibody agents. Their structural [29][30][31][32], spectral [22,33,34], thermal [34], antibacterial [22,34] and antifungal [34] properties have been described.…”

“…Three ligand approaches are suggested [19][20][21][22]: transporters, which provide metal transport to infection, carriers which provide metal transport and its gradual delivery, multifunctional ligands, that can act as transporters, carriers and antibiotics or analgetics simultaneously.…”

“…% in 1, 30 wt. % Ag(I) sulfadiazine) and silver coordination mode (AgNO 3 -predominantly ionicinteractions, 1 -predominantly covalent interactions)[22].…”

Synthesis of Mixed Ligand Ruthenium (II/III) Complexes and Their Antibacterial Evaluation on Drug-Resistant Bacterial Organisms

“…is has a negative or positive effect on the target bacterial organism or biological function [11]. e most common choice of ligands is either the Schiff base ligands [13][14][15][16] or heterocyclic polypyridyl ligands, with the latter being the most common [17][18][19][20][21][22]. Polypyridyl ligands have one or more pyridine rings, and these are important ligands in coordination chemistry.…”