Antibacterial Cascade Catalytic Glutathione-Depleting MOF Nanoreactors

Abstract

Nanozymes with peroxidase-like activity have great application potential in combating pathogenic bacterial infections and are expected to become an alternative to antibiotics. However, the near-neutral pH and high glutathione (GSH) levels in the bacterial infection microenvironment severely limit their applications in antibacterial therapy. In this work, a metal−organic framework (MOF)-based cascade catalytic glutathione-depleting system named MnFe 2 O 4 @MIL/Au&GOx (MMAG) was constructed. The MMAG cascade-catalyzed glucose to provide H + and produces a large amount of toxic reactive oxygen species. In addition, MMAG consumed GSH, which can result in bacterial death more easily. Systematic antibacterial experiments illustrated that MMAG has superior antibacterial effects on both Gram-positive bacteria and Gram-negative bacteria.

Mediating Point Defects Endows n‐Type Bi2Te3 with High Thermoelectric Performance and Superior Mechanical Robustness for Power Generation Application

“…b) The statistic relationship between ZT and Vickers hardness/compressive strength in n‐type Bi 2 Te 3 alloys. [ 19,23–28,33,34 ] c) The measured conversion efficiency as a function of temperature difference (Δ T ) for our fabricated Bi 2 Te 2.9 S 0.1 (TeI 4 ) 0.0012 (n)/Bi 0.4 Sb 1.6 Te 3.01 (p) module and previous data of Bi 2 Te 3 ‐based modules, including Bi 0.35 Sb 1.65 Te 2.96 Se 0.04 + 3 wt.% Te (p)/ ZM Bi 2 Te 2.5 Se 0.5 + 1.5 mol% CuBr 2 (n), [ 35 ] Bi 0.4 Sb 1.597 Pb 0.003 Te 3 (p)/ZM Bi 2 Te 2.5 Se 0.5 + 1.5 mol% CuBr 2 (n), [ 36 ] Bi 1.52 Sb 1.48 Te 3 (p)/Bi 2 Te 2.7 Se 0.3 + 1 wt.% Bi 2 S 3 (n), [ 37 ] Bi 0.5 Sb 1.49 Cd 0.01 Te 3 (p)/ hot extruded Bi 2 Te 3 ‐based materials (n), [ 38 ] Bi 2 Te 3 ‐based conventional module (ZM for both n/p), [ 20 ] selective laser melting Bi 0.4 Sb 1.6 Te 3 (p)/ZM Bi 2 Te 2.7 Se 0.3 (n), [ 20 ] ZM Bi 0.5 Sb 1.5 Te 3 (p)/ZM Bi 2 Te 2.7 Se 0.3 (n) [ 39 ] and melt spun Zn 0.015 Bi 0.46 Sb 1.54 Te 3.015 (p)/ ZM Bi 2 Te 2.7 Se 0.3 (n) [ 39 ] modules.…”

Confining enzymes in porous organic frameworks: from synthetic strategy and characterization to healthcare applications

“…Inspired by the intrinsic enzyme-mimic property of some MOFs that display Fenton/Fenton-like activity, a combination of GOx and peroxidase-like MOF nanozymes to set up a self-activated cascade nanosystem was explored, in which the generated H 2 O 2 from the GOx-catalyzed process could be continuously catalyzed to form highly toxic radicals by MOFs. [270][271][272] For instance, Qu and co-workers designed an ultrathin 2D Cu-TCPP (Fe) MOF nanosheet possessing peroxidase-mimic activity, and then GOx was adsorbed on the surface of Cu-TCPP (Fe). 270 The generated gluconic acid decreased the pH value from 7 to 3-4, significantly enhancing the peroxidase-like activity of Cu-TCPP (Fe) at the optimal pH condition, thus resulting in the efficient generation of OH to kill bacteria.…”

Multifunctional Wearable Thermoelectrics for Personal Thermal Management

“…Here, near‐room temperature thermoelectric materials suitable for thermoelectric PTM can be classified into nonflexible and flexible types as summarized in Figure . Figure 6a and Table 1 summarize nonflexible thermoelectric materials with high near‐room temperature thermoelectric performance, which are mainly are bulk inorganic materials, such as Bi 2 Te 3 ‐based, [ 80–86 ] Ag 2 Se‐based, [ 87 ] and Mg 2 Bi 3 ‐based thermoelectric materials. [ 88 ] Among them, bulk Bi 2 Te 3 ‐based thermoelectric materials are the most well‐developed and widely applied mainly due to their high S 2 σ values, which have approached the ultrahigh near‐room temperature zT of 1.18 (300 K) of n‐type Bi 2 Te 2.7 Se 0.3 [ 89 ] and 1.86 (320 K) of p‐type Bi 0.5 Sb 1.5 Te 3 .…”