Antibacterial constituents of the plant family Amaryllidaceae

Nair, Jerald J.; Wilhelm, Anke; Bonnet, Susan L.; Staden, J. Van

doi:10.1016/j.bmcl.2017.09.052

Cited by 56 publications

(51 citation statements)

References 31 publications

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“…This may be due to the fact that the ethanolic extracts contain more biologically active phytochemicals than the chloroform extract. Overall, results revealed that extracts are potential source of bioactive compounds and these findings are in line with previous studies (Bajalan et al, 2017;Fakhfakh et al, 2017;Giacomini et al, 2017;Meng et al, 2017;Nair et al, 2017;Palanisamy et al, 2017;Paliwal et al, 2017;Sagbo et al, 2017).…”

Section: Antibacterial Activities Of Fruit Extractssupporting

confidence: 92%

Comparative study of the antioxidant and antibacterial activities of two guava (Psidium guajava) fruit varieties cultivated in Andasa Horticulture Site, Ethiopia

Int¹

2019

Preprint

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This investigation was carried out to evaluate the levels of phytochemicals and antioxidant potential as well as antibacterial activity of the two varieties of guava (Psidium guajava) fruit collected from Andasa horticulture site, Ethiopia. The antioxidant potential for guava fruit extracts was assessed using different in-vitro antioxidant assays, namely reducing power, Folin-Ciocalteu (F-C) assay and aluminum chloride methods. Overall, the white flesh guava fruit exhibited the highest levels of TPC, TFC and reducing power than the pink flesh guava. The mg/100g of AEAC (FRAP assay), AEAC (PMA), GAE and QE of pink and white flesh guava fruits determined in this study were 125.73, 260.28, 262.78, 377.18, 21.25, 24.61, 7.05 and 22.10, respectively. Antibacterial property of the two guava fruit variety extracts was evaluated against three gram-positive and two gram-negative bacteria using agar well diffusion technique. Ethanol extracts from both pink and white flesh guava exhibited antibacterial activity with zone of inhibition ranging from 29.50 to 30.33 and 24.33 to 29.33 mm respectively. On the other hand, only the chloroform extract from pink flesh guava showed poor antibacterial activity against MRSA and Shigella pathogens among the five tested organisms and the zone of inhibition measured was 11 and 10 mm respectively.

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Section: Antibacterial Activities Of Fruit Extractssupporting

confidence: 92%

Comparative study of the antioxidant and antibacterial activities of two guava (Psidium guajava) fruit varieties cultivated in Andasa Horticulture Site, Ethiopia

Int¹

2019

Preprint

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“…Amaryllidaceae family plants are well known as an extensive source of pharmacologically active alkaloids [10][11][12][13], and lycorine was the first among these alkaloids to be isolated in 1877 from the plant Narcissus pseudonarcissus [14]. From then onwards, lycorine and its derivatives are drawing interest in the medicinal field due to their divergent chemical structures and strong biological effects [ Fig.…”

Section: Introductionmentioning

confidence: 99%

Lycorine: A prospective natural lead for anticancer drug discovery

Roy

Liang

Xiao

et al. 2018

Biomedicine & Pharmacotherapy

120

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Nature is the most abundant source for novel drug discovery. Lycorine is a natural alkaloid with immense therapeutic potential. Lycorine is active in a very low concentration and with high specificity against a number of cancers both in vivo and in vitro and against various drug-resistant cancer cells. This review summarized the therapeutic effect and the anticancer mechanisms of lycorine. At the same time, we have discussed the pharmacology and comparative structure-activity relationship for the anticancer activity of this compound. The researches outlined in this paper serve as a foundation to explain lycorine as an important lead compound for new generation anticancer drug design and provide the principle for the development of biological strategies to utilize lycorine in the treatment of cancers.

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“…As also seen for the majority of biological screens of lycorane alkaloids (Bastida et al, ), the parent compound lycorine was the most studied alkaloid of the group in assays of fungal pathogenesis (Bonvicini et al, ; De Leo, Dalessandro, De Santis, & Arrigoni, ; Evidente et al, ; Jimenez et al, ; Ločárek et al, ; Onofri, Barreca, & Garuccio, ). In contrast to its lack of activity against most bacterial pathogens (Nair, Wilhelm, Bonnet, & Van Staden, ), lycorine ( 5 ) was notably more active in the six fungal cultures against which it has been screened. The first of such studies was that undertaken by De Leo et al () wherein lycorine exhibited potent inhibitory activity (97.3%) against growth of the yeast S. cerevisiae (Table ).…”

Section: Antifungal Activities Of Isolatesmentioning

confidence: 92%

Antifungal constituents of the plant family Amaryllidaceae

Nair

Staden

2018

Phytotherapy Research

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Globalization, the modern lifestyle, immuno-suppressive agents, invasive surgical procedures, the loss of efficacies of existing drugs, and multidrug resistance are some of the factors used to explain the rise in fungal infections in recent years. Significant advances have been made in attempts to replace existing antifungal schedules, especially with synthetic targets. The identification of other platforms for drug discovery is now entrenched in research programs across the globe. Plants offer significant benefits owing to their numerical superiority, exceedingly broad chemical basis and appealing sustainability characteristics. Furthermore, plants have a long and rich historical association with traditional approaches towards fungal diseases. These have in numerous instances served as markers in the bioassay-guided identification of the active constituents. Although the plant family Amaryllidaceae is conventionally associated with cancer and motor-neuron disease chemotherapies, around 30 of its species have been examined for antifungal activities with microgram per millilitre inhibitory activities detected in several instances. This review focuses on the nearly 40 constituents from the family, mainly isoquinoline alkaloids, which have been screened against around 50 fungal pathogens. Encouragingly, microgram per millilitre growth inhibitory activities were applicable for several of the compounds with a minimum inhibitory concentration of 4 μg/ml seen to be the lowest.

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Antibacterial constituents of the plant family Amaryllidaceae

Cited by 56 publications

References 31 publications

Comparative study of the antioxidant and antibacterial activities of two guava (Psidium guajava) fruit varieties cultivated in Andasa Horticulture Site, Ethiopia

Comparative study of the antioxidant and antibacterial activities of two guava (Psidium guajava) fruit varieties cultivated in Andasa Horticulture Site, Ethiopia

Lycorine: A prospective natural lead for anticancer drug discovery

Antifungal constituents of the plant family Amaryllidaceae

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