Antibacterial, Cytotoxic Studies and Characterization of Some Newly Synthesized Symmetrical N³,N^3′‐Bis(disubstituted)isophthalyl‐bis(thioureas) and Their Cu(II) and Ni(II) Complexes

Abstract

A series of some novelN3,N3′-bis(disubstituted)isophthalyl-bis(thioureas) compounds with general formula [C6H4·{CONHCSNHR}2], where R = 2-ClC6H4S (L1), 3,5-(Cl)2C6H3(L2), 2,4-(Cl)2C6H3(L3), 2,5-(Cl)2C6H3(L4), and 2-NH2C6H4(L5), and their Cu(II) and Ni(II) complexes (C1–C10) have been synthesized. These compounds (L1–L5) and their metal(II) complexes (C1–C10) have been characterized by elemental analysis, infrared spectroscopy,1H NMR and13C NMR spectroscopy, magnetic moments, and electronic spectral measurements. The ligands are coordinated to metal atom in a bidentate pattern producing a neutral complex of the type [ML]2. These compounds (L1–L5) and their metal(II) complexes (C1–C10) were also screened for their antibacterial and cytotoxic activities.

Characterization and Antimicrobial Studies of Five Substituted Bis-Thioureas

“…Some example of bis-thiourea derivatives are N 3 , N 3' -bis (disubstituted)isophatalyl-bis(thiourea), bis(thiourea)hydrazide [13], 2,2'-diaminobinapthalene-bis(thiourea) [14] and (bis)thiourea polyamine [15] [16,17,18]. In 2011, 1,2-Bis(N'-benzoylthioureidothioureido)-4-cholorobenzene was reported by Yamin research group [19].…”