Antibacterial effect and proposed mechanism of action of a topical surgical adhesive

Prince, Daniel L.; Solanki, Zankhna; Varughese, Remy; Mastej, Jozef; Prince, Derek

doi:10.1016/j.ajic.2017.07.008

Cited by 27 publications

(11 citation statements)

References 4 publications

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“…20 Four of five isolates in the four cultures from horses with NBC skin closure were gram-negative bacteria, which are not as susceptible as gram-positive organisms to the bactericidal properties of cyanoacrylates. 29 In the present study, incisional drainage was noted at a median of 7 days postoperatively (range, 0-19). Typically, the adhesive film sealing the surgery site created by the cyanoacrylate sloughs between 5 and 10 days after application.…”

Section: Discussionmentioning

confidence: 63%

“…28 We decided to divide the study population into in-hospital and posthospital discharge incisional complications because additional incisional complications were detected only after the horse had left the hospital. There is evidence that cyanoacrylates have antibacterial effects against gram-positive 29 and some gram-negative 32 bacteria, such as Staphylococcus spp (including methicillinresistant S aureus), Streptococcus spp, Corynebacterium, E coli, Pseudomonas aeruginosa, and Klebsiella pneumonia. In the present study, several of these bacteria were isolated from surgical sites that had positive culture results.…”

Section: Discussionmentioning

confidence: 99%

“…25 Furthermore, authors from previous equine laparotomy studies 30,31 have reported lower prevalence of incisional complications when avoiding a percutaneous pattern. 28,29 Even though an intradermal or subcutaneous layer may provide sufficient apposition, additional strength is provided by incorporating cyanoacrylate to the closure, without compromising the skin barrier.…”

Section: Discussionmentioning

confidence: 99%

“…There is evidence that cyanoacrylates have antibacterial effects against gram‐positive 29 and some gram‐negative 32 bacteria, such as Staphylococcus spp (including methicillin‐resistant S aureus ), Streptococcus spp, Corynebacterium , E coli , Pseudomonas aeruginosa , and Klebsiella pneumonia . In the present study, several of these bacteria were isolated from surgical sites that had positive culture results.…”

Section: Discussionmentioning

confidence: 99%

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Incisional complications after skin closure with n‐butyl cyanoacrylate or stainless‐steel skin staples in horses undergoing colic surgery

2020

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Objective: To compare the prevalence of incisional complications after skin closure with n-butyl cyanoacrylate (NBC) or stainless-steel skin staples (SS) after ventral midline celiotomy for colic surgery in the horse. Study design: Retrospective study (2014-2018). Animals: Two hundred eighteen horses. Methods: Medical records of horses that underwent exploratory celiotomy for colic were included when the skin was closed with NBC or SS and the horse survived ≥15 days after surgery. Records and a follow-up questionnaire were used to determine in-hospital and posthospital discharge incisional complications. Associations between variables were assessed by using bivariable and multivariable analysis. Results: The cutaneous incision was closed with SS in 113 of 218 (51.8%) horses and with NBC in 105 of 218 (48.2%) horses. Follow-up information was available in 166 of 218 horses. Five horses with incisional complications prior to discharge but without follow-up were included in the overall analysis. Incisional complications were recorded in 17.5% (30/171) of horses, including 19.1% (17/89) of closures with SS and 15.9% (12/82) of closures with NBC (P = .54). Complications occurred before discharge in 14 of 218 (6.4%) horses and after discharge in 16 of 166 (9.6%) horses. Four horses with in-hospital incisional complications (surgical site infection) developed a second complication after discharge (hernia). Packed cell volume was a risk factor for in-hospital incisional complications (P = .04), and in-hospital incisional complications were associated with posthospital discharge incisional complications (P = .01).

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Incisional complications after skin closure with n‐butyl cyanoacrylate or stainless‐steel skin staples in horses undergoing colic surgery

2020

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“…10 Male circumcision had a relatively low incidence of adverse events overall, especially if the procedure was performed during the first year of life, but rose 10-20 fold when performed after infancy. 11 The cyanoacrylate tissue glue has been claimed to have the advantages of being hemostatic, 12 bacteriostatic [13][14][15][16][17] and easy to use; moreover, the stitch marks along the suture lines can be avoided, allowing for better cosmetic results.…”

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confidence: 99%

Pediatric circumcision using n‐butyl‐cyanoacrylate plusMSmonomer: Bacteriostatic and cosmetic advantages over suture

et al. 2020

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Bioadhesives with Antimicrobial Properties

et al. 2023

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Bioadhesives with antimicrobial properties enable easier and safer treatment of wounds as compared to the traditional methods such as suturing and stapling on a variety of medical conditions. Composed of natural or synthetic polymers, these bioadhesives seal wounds and facilitate healing while preventing infections through the activity of locally released antimicrobial drugs, nanocomponents or inherently antimicrobial polymers. Although many different materials and strategies are employed to develop antimicrobial bioadhesives, the design of these biomaterials necessitates a prudent approach as achieving all the required properties including optimal adhesive and cohesive properties, biocompatibility, and antimicrobial activity can be challenging. Designing antimicrobial bioadhesives with tunable physical, chemical and biological properties will shed light on the path for future advancement of bioadhesives with antimicrobial properties. In this review, we discuss the requirements and commonly used strategies for developing bioadhesives with antimicrobial properties. In particular, we will summarize different methods for their synthesis and will review their experimental and clinical applications on a variety of organs. Advances in the design of bioadhesives with antimicrobial properties will pave the way for a better management of wounds to increase positive medical outcomes.This article is protected by copyright. All rights reserved

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Antibacterial effect and proposed mechanism of action of a topical surgical adhesive

Cited by 27 publications

References 4 publications

Incisional complications after skin closure with n‐butyl cyanoacrylate or stainless‐steel skin staples in horses undergoing colic surgery

Incisional complications after skin closure with n‐butyl cyanoacrylate or stainless‐steel skin staples in horses undergoing colic surgery

Pediatric circumcision using n‐butyl‐cyanoacrylate plusMSmonomer: Bacteriostatic and cosmetic advantages over suture

Bioadhesives with Antimicrobial Properties

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