Antibacterial Effect of Ethanolic and Methanolic Extracts of Plantago ovata 
 and Oliveria decumbens Endemic in Iran Against Some Pathogenic Bacteria

Motamedi, Hossein; Darabpour, Esmaeil; Gholipour, M.; Nejad, Seyyed Mansour Seyyed

doi:10.3923/ijp.2010.117.122

Cited by 45 publications

(26 citation statements)

References 14 publications

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“…These herbs might have inhibited the proliferation and growth of microorganism and resolved the inflammatory process that led to the overall improvement in cervicitis. Recent studies also confirmed that these herbs possess antimicrobial, [18][19][20][21] antiinflammatory, [22][23][24] antioxidant, [25][26] analgesic, [22,24,26] immunomodulator [27] and wound healing properties [28]. Study reveals Isapgol to have antimicrobial activity against Staphylococcus aureus [20] and Escherichia coli [39] while Linseeds have wide range of activity against Staphylococcus aureus, Bacillus cereus, Klebsiella pneumonia [21].…”

Section: Discussionmentioning

confidence: 94%

“…Various ingredients of above formulation shown to have antimicrobial, [18][19][20][21] anti-inflammatory, [22][23][24] antioxidant, [25][26] analgesic, [22,24,26] immunomodulator [27] and wound healing properties [28]. Considering the aforementioned fact, the present study was carried out to evaluate the efficacy PHUFs in the management of cervicitis.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Unani Formulation in Cervicitis (Warme-unqur-rahm): A Single-blind Randomized Placebo-controlled Trial

Zahid¹,

Rehman²

2016

Altern Integr Med

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Objective: To evaluate the efficacy and safety of Polyherbal Unani formulations (PHUFs) with placebo in Warmeunqur-rahm (Cervicitis). Methods:A Randomized single-blind placebo controlled trial was designed to compare the efficacy of Unani formulations against placebo in diagnosed cases of cervicitis in the Department of Gynaecology of Ayurvedic & Unani Tibbia College, Delhi. Sixty married female participants with age group of 18-40 years having symptoms of cervicitis with no systemic illness and sexually transmitted diseases and not using oral or intrauterine contraceptives were randomly allocated to receive either test drug (n = 30) or placebo (n = 30) for three months.In the test group, sufoofe sailan (PHUF) 5 gm orally was given twice daily and intravaginally humul (pessary) of isapghol (Isapgol: Plantago ovata Forsk) and alsi (Linseed: Linum usitatissimum L.) soaked in arqe gulab (rose water) was kept at mid-cycle for 10 days for three consecutive cycles and the placebo was given for same protocol. On the basis of improvement in subjective and objective parameters the response of treatment was graded as cured, improved and not cured. Results were analyzed by Chi-square/Fisher Exact test and Student t test. Results:There was a significant improvement in the subjective and objective parameters in test group after treatment with P < 0.001. Cervical discharge, cervical erythema and cervical oedema were significantly reduced (P < 0.001) after three months of treatment. Interpretation and conclusion: Study revealed that test drug formulations were effective and safe in the management of cervicitis. Besides, the trial should be conducted on large sample size for effectiveness of drug.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Effect of Unani Formulation in Cervicitis (Warme-unqur-rahm): A Single-blind Randomized Placebo-controlled Trial

Zahid¹,

Rehman²

2016

Altern Integr Med

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“…The ethylation and carboxymethylation of arabinoxylan, isolated from P. ovata seed husk, were carried out (Saghir et al, 2008). Antimicrobial activity of ethanolic and methanolic extract of P. ovata has been reported against Gram positive and Gram negative bacteria (Motamedi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Modified and unmodified arabinoxylans from <i>Plantago ovata</i> husk: Novel excipients with antimicrobial potential

Erum

Bashir

Saghir³

2015

Bangladesh J Pharmacol

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Arabinoxylan is a polysaccharide of Plantago ovata, an indigenous plant of Pakistan and several European countries. In the present investigation arabinoxylan isolated from P. ovata husk was chemically modified i.e., carboxymethylated and was converted into its sodium salt. Physicochemical characterization of modified arabinoxylans was done. The antimicrobial assay of arabinoxylan and modified arabinoxylans was done by Kirby-Bauer disk diffusion method against Gram negative and Gram positive bacterial strains. Physicochemical properties of modified arabinoxylans were different from arabinoxylan yet were satisfactory for their use as pharmaceutical excipients. Arabinoxylan showed strong antimicrobial activity against Gram positive strains. However, it showed no antimicrobial activity against Gram negative strains. Carboxymethyl arabinoxylan showed maximum activity against S. epidermidis. It also showed activity against S. aureus and P. aeruginosa. Arabinoxylan Na showed concentration-dependent antimicrobial activity. This study provides the first report on the antibacterial properties of arabinoxylan and its modified forms. Article Info

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“…The sub-fractions obtained were more active against Gram-positive bacteria than Gram-negative bacteria. This difference could be due to the cell wall structure of Gram-negative bacteria, which is more complex than that of Gram-positive bacteria, the membrane accumulation mechanisms in Gram-negative bacteria, or the mechanism of destruction of molecules introduced from the outside, that is caused by the presence of enzymes in the periplasmic space (Motamedi et al, 2010). Besides that, the difference results could be caused by different concentration from each sub-fractions.…”

Section: Antibacterial Activitymentioning

confidence: 99%

Identification and Evaluation of Antibacterial Compounds from the Vibrio sp. associated with the Ascidian Pycnoclavella diminuta

Dermawan¹,

Julianti²,

Putra³

et al. 2019

psr

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This study aims to obtain secondary metabolites that have antibacterial activity from bacteria endophytic of ascidian Pycnoclavella diminuta collected from the coast of Bitung, North Sulawesi, Indonesia. The research was started with screening antibacterial activity of six bacteria isolated from P. diminuta. The active bacteria were selected for identification using standard biological molecular method and further fermentation to produce secondary metabolites. The isolation of secondary metabolites was conducted by various chromatography method and then selected fraction was based on the antibacterial activity from bioautography results. The result showed that the active isolate by coding M2.Tnk.Bt 5.10-3 .2 was identified as Vibrio sp. The potential active fraction was further sub-fractionated by HPLC semi-preparative and each of these sub-fractions was tested against Staphylococcus aureus, Bacillus cereus, Enterococcus faecalis, Eschericia coli, and Vibrio cholerae. The test results showed that all 17 sub-fractions were active against Gram-positive bacteria S. aureus and B. cereus, and only one sub-fraction (SFr 2) showed antibacterial activity against E. faecalis. Whereas in Gram-negative bacteria, 2 sub-fractions (SFr 12 and SFr 13) showed antibacterial activity against E. coli and 12 sub-fractions active against V. cholerae. GC-MS analysis of the SFr 2 sub-fraction showed the presence of fifteen phytochemical constituents with a major compound Pyrrolo [1,2-a] pyrazine-1,4-dione, hexahydro-3-(2 methylpropyl).

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Antibacterial Effect of Ethanolic and Methanolic Extracts of Plantago ovata and Oliveria decumbens Endemic in Iran Against Some Pathogenic Bacteria

Cited by 45 publications

References 14 publications

Effect of Unani Formulation in Cervicitis (Warme-unqur-rahm): A Single-blind Randomized Placebo-controlled Trial

Effect of Unani Formulation in Cervicitis (Warme-unqur-rahm): A Single-blind Randomized Placebo-controlled Trial

Modified and unmodified arabinoxylans from <i>Plantago ovata</i> husk: Novel excipients with antimicrobial potential

Identification and Evaluation of Antibacterial Compounds from the Vibrio sp. associated with the Ascidian Pycnoclavella diminuta

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