Antibacterial Effect of Java Turmeric Ethanol Extract Against Dual-Species Streptococcus Mutans and Streptococcus Sanguinis Biofilm (In Vitro)

Busri, Ajrina; Puspitawati, Ria; Utami, Sri

doi:10.22159/ajpcr.2017.v10s5.23096

Cited by 5 publications

(7 citation statements)

References 7 publications

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“…This effect may have been caused by xanthorrhizol and flavonoids contained in IJTEE that have antibacterial effects. This is supported by previous research which stated that IJTEE was able to decrease biofilm viability [13].…”

Section: The Effectiveness Of Identified Javanese Turmeric Ethanol Exsupporting

confidence: 84%

“…Our findings can also be compared with those of previous research in which MIC and MBC of IJTEE against S. mutans were identified [13].…”

Section: Discussionsupporting

confidence: 55%

“…We suspect that IJTEE has an effect on inhibiting the formation of biofilm by P. gingivalis, but its effectiveness was not equivalent to that of CHx, which has a strong antibacterial effect in penetrating the biofilm extracellular matrix. In addition, P. gingivalis has a more complex cell wall that can limit the diffusion of foreign matter into cells [13]. Fig.…”

Section: The Effectiveness Of Identified Javanese Turmeric Ethanol Exmentioning

confidence: 99%

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Effectiveness of Identified Javanese Turmeric Ethanol Extract for the Inhibition of Biofilm Formation by Streptococcus Mutans and Porphyromonas Gingivalis

Marpaung

Suniarti²,

Sarwono³

2019

Int J App Pharm

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Objective: To study the effectiveness of identified Javanese turmeric ethanol extract (IJTEE) against single and combined biofilm formation byStreptococcus mutans and Porphyromonas gingivalis.Methods: S. mutans ATCC 25175 and P. gingivalis ATCC 33277 were tested for the minimum inhibitory concentration (MIC) and minimum bactericidalconcentration (MBC) of IJTEE using microdilution technique. The inhibition of biofilm formation by IJTEE was analyzed using crystal violet assay.Results: MIC and MBC of IJTEE for S. mutans were 5% and 15%, respectively. MIC of IJTEE for the biofilm of S. mutans was 1% and for that ofP. gingivalis was 15%; the MIC of IJTEE for the combined biofilm was 0.5%.Conclusion: IJTEE was effective in inhibiting single and combined biofilm formation by S. mutans and P. gingivalis.

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Section: The Effectiveness Of Identified Javanese Turmeric Ethanol Exsupporting

confidence: 84%

“…Our findings can also be compared with those of previous research in which MIC and MBC of IJTEE against S. mutans were identified [13].…”

Section: Discussionsupporting

confidence: 55%

Section: The Effectiveness Of Identified Javanese Turmeric Ethanol Exmentioning

confidence: 99%

See 1 more Smart Citation

Effectiveness of Identified Javanese Turmeric Ethanol Extract for the Inhibition of Biofilm Formation by Streptococcus Mutans and Porphyromonas Gingivalis

Marpaung

Suniarti²,

Sarwono³

2019

Int J App Pharm

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“…To determine the antibacterial efficacy between the individual and different combination of drugs, the following combinations, namely CEF+TR; CEF+ME and the clinical strain of MRSA have been studied in the following assay using the checkerboard method. Aliquots of log phase bacterial culture (turbidity of 0.5 McFarland standard) were transferred to microtiter plates containing tested concentrations of drugs as inferred from the minimum inhibitory concentration (MIC) assay [9,10]. The combination of different concentrations was used in the study.…”

Section: Checkerboard Methods For Studying Interaction Between Antibimentioning

confidence: 99%

Nonantibiotics Enhance the Antibacterial Activity of Ceftriaxone Against Methicillin-Resistant Staphylococcus Aureus

Krishnan

Kandasamy

2018

Asian J Pharm Clin Res

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Objectives: Antibiotic resistance is one of the most persistent issues worldwide nowadays, and methicillin-resistant Staphylococcus aureus (MRSA) infection is one such issue where the standard therapeutic procedures involving powerful antibiotics have failed in controlling the infection.Methods: In the present study, the antibacterial potency of the nonantibiotics troxipide (TR), mebeverine hydrochloride (Hcl), and their combinations with ceftriaxone (CEF) against MRSA has been investigated using microbiological assays of microplate dilution method and combination index interpretations of the nonantibiotics with β-lactam antibiotic CEF and the zone of inhibition method.Results: The nonantibiotics ME and TR inhibited resistant strain tested in vitro in the checkerboard assay, where the results showed that CEF and TR exhibited minimum inhibitory concentration (MIC) at concentrations of 50 μg/ml and 318 μg/ml, respectively. Interestingly, CEF when combined with TR reduced the MIC to 8 μg/ml and 78 μg/ml. According to the results, CEF with TR exhibited synergistic interactions at the fractional inhibitory concentration of 0.36–1.4. ME and TR and its combinations, CEF with ME, and CEF with TR have considerable anti-MRSA efficacy, with synergism though at 36 h of incubation.Conclusion: ME and TR being antispasmodic and antiulcer drugs can also be used against MRSA infections, which could prove to be favorable in the reduction of dosage of antibiotics such as CEF, and cutting down the need for additional administration of antibiotics to the patients affected with multiple complications such as gastrointestinal ulcer, spasm difficulties, and infection.

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“…Streptococcus mutans is a pathogen bacterium associated with dental caries and cavities. S. mutans bacteria form a colony on teeth surface as dental plaque and convert extracellular polysaccharide to lactic acid through fermentation and eventually caused teeth caries [2,3]. Toothpaste and mouthwash which are used in mouth care can contain natural components as thymol or synthetic components like chlorhexidine; however, those containing synthetic ingredients are usually associated with teeth staining [4,5].…”

Section: Introductionmentioning

confidence: 99%

Estimation the Antibacterial Effect of Curcumin and Rosemary Among Patients With Dental Caries in Vitro

Al-Sharifi¹,

Al-Mahmood²,

Al-Mahmood³

2019

Asian J Pharm Clin Res

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Objective: The aim is to estimate the effect of curcumin and rosemary as antibacterial agents among dental caries cases. Methods: Samples of saliva were randomly collected from 40 patients in Al-Furat General Hospital who attended the hospital from July to September 2018. Swabs were cultured on blood agar at 37°C for 24 h and then subcultured in mannitol salt agar and trypticase soy broth at 37°C for 24 h. Different concentrations of aqueous extract curcumin solution (0.1, 0.3, 0.5, and 1 mg/ml) and rosemary solution (1 g/ml) were prepared and added to the bacterial culture. Later, minimum inhibition zones of the bacterial cultures were determined. Results: The results showed that there were 25 cases of Streptococcus mutans, 10 cases of Staphylococcus aureus, 3 cases of anaerobic bacteria, and 2 cases of normal flora among 40 culturing swabs of bacteria. Aqueous extract of curcumin showed antibacterial effect with concentrations (0.1, 0.3, 0.5, and 1 mg/ml) against oral bacteria; nevertheless, these bacteria were resistant to the aqueous extract of rosemary with concentration 1 g/ml. Conclusion: It can be concluded that curcumin can be an effective antibacterial agent against dental caries disease and its effect increases positively in relation to its concentration. On the other hand, rosemary with 1 g/ml concentration did not show any effect on oral bacteria.

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Antibacterial Effect of Java Turmeric Ethanol Extract Against Dual-Species Streptococcus Mutans and Streptococcus Sanguinis Biofilm (In Vitro)

Cited by 5 publications

References 7 publications

Effectiveness of Identified Javanese Turmeric Ethanol Extract for the Inhibition of Biofilm Formation by Streptococcus Mutans and Porphyromonas Gingivalis

Effectiveness of Identified Javanese Turmeric Ethanol Extract for the Inhibition of Biofilm Formation by Streptococcus Mutans and Porphyromonas Gingivalis

Nonantibiotics Enhance the Antibacterial Activity of Ceftriaxone Against Methicillin-Resistant Staphylococcus Aureus

Estimation the Antibacterial Effect of Curcumin and Rosemary Among Patients With Dental Caries in Vitro

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