Antibacterial effect of nanometer‐size grafted layer of quaternary ammonium polymer on poly(ether ether ketone) substrate

Oai, Keiko; Inoue, Yasuo; Nakao, Aiko; Fukazawa, Kyoko; Ishihara, Kazuhíko

doi:10.1002/app.49088

Cited by 12 publications

(11 citation statements)

References 66 publications

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“…23 They were attributed to the phosphorus atom in the phosphate group and the nitrogen atom in the trimethylammonium group, respectively, in the phosphorylcholine group. 26,27 These results indicated that the MPC polymer layer was formed on the surface. 12,13 AFM is one of the most promising surface characterization tools that is capable of revealing the nanoscopic morphological features with high resolution.…”

Section: ■ Introductionmentioning

confidence: 79%

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Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface

et al. 2021

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Inspired by the cell membrane surface as well as the ocular tissue, a novel and clinically applicable antifouling silicone hydrogel contact lens material was developed. The unique chemical and biological features on the surface on a silicone hydrogel base substrate were achieved by a cross-linked polymer layer composed of 2-methacryloyloxyethyl phosphorylcholine (MPC), which was considered important for optimal on-eye performance. The effects of the polymer layer on adsorption of biomolecules, such as lipid and proteins, and adhesion of cells and bacteria were evaluated and compared with several conventional silicone hydrogel contact lens materials. The MPC polymer layer provided significant resistance to lipid deposition as visually demonstrated by the three-dimensional confocal images of whole contact lenses. Also, fibroblast cell adhesion was decreased to a 1% level compared with that on the conventional silicone hydrogel contact lenses. The movement of the cells on the surface of the MPC polymer-modified lens material was greater compared with other silicone hydrogel contact lenses indicating that lubrication of the contact lenses on ocular tissue might be improved. The superior hydrophilic nature of the MPC polymer layer provides improved surface properties compared to the underlying silicone hydrogel base substrate.

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Section: ■ Introductionmentioning

confidence: 79%

“…As previously reported, the hydrophilic nature and water-compatible characteristics of the MPC polymer coating contribute to the reduction of bacterial adhesion on the new lens surface. 15 , 25 , 61 …”

Section: Resultsmentioning

confidence: 99%

Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface

et al. 2021

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“…These macromolecules often mimic the physiochemical properties of AmPs leading to their antibacterial activity, while being more cost-effective and scalable . Some common examples include quaternary ammonium polymers, polymethacrylates, poly[2-(dimethyl decyl ammonium)ethyl methacrylate], poly-β-peptides, − and polyimidazolium. , Guo et al investigated the relationship between polymer structure and antimicrobial properties of several antimicrobial compounds, finding a greater antibacterial efficacy in main-chain cationic polymers than side-chain cationic polymers. Overall, this study found that the side-chain/main-chain cationic polymers synthesized with small molecule cationic compounds, including imidazolium, quaternary ammonium, and 1,4-diazabicyclo[2.2.2]octane-1,4-diium, had greater antibacterial efficacy than their corresponding small molecule cationic constituents.…”

Section: Recent Advances In Treatments For Bacterial Infectionsmentioning

confidence: 99%

Recent Innovations in Bacterial Infection Detection and Treatment

2021

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Bacterial infections are a major threat to human health, exacerbated by increasing antibiotic resistance. These infections can result in tremendous morbidity and mortality, emphasizing the need to identify and treat pathogenic bacteria quickly and effectively. Recent developments in detection methods have focused on electrochemical, optical, and mass-based biosensors. Advances in these systems include implementing multifunctional materials, microfluidic sampling, and portable data-processing to improve sensitivity, specificity, and ease of operation. Concurrently, advances in antibacterial treatment have largely focused on targeted and responsive delivery for both antibiotics and antibiotic alternatives. Antibiotic alternatives described here include repurposed drugs, antimicrobial peptides and polymers, nucleic acids, small molecules, living systems, and bacteriophages. Finally, closed-loop therapies are combining advances in the fields of both detection and treatment. This review provides a comprehensive summary of the current trends in detection and treatment systems for bacterial infections.

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“…Poly (ether ether) ketone (PEEK), which is a widely used material for bone implants, was photochemically modified by utilizing a "grafting to" approach by cationic, quaternary ammonium containing methacrylate polymer brushes, influencing cell-surface interaction [93]. The material had an anti-adhesive effect against E. coli, resulting in less than 1% of the bacteria adhering to the samples.…”

Section: Non-biodegradable Polymersmentioning

confidence: 99%

“…There are various polymers with good biocompatibility and biodegradable properties, which are preferred in the design of new materials [ 63 , 174 , 197 , 198 ]. Among the non-biodegradable polymers such as polyethylene (PE), polyethylene terephthalate (PET) or poly (ether ether) ketone (PEEK), there are some modified versions that may qualify as antimicrobial surfaces [ 60 , 92 , 93 ]. Most research studies, however, have focused on biodegradable polymers as these have the ability to be replaced by natural tissue [ 11 ].…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution

Riester

Borgolte

Csuk

et al. 2020

IJMS

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An aging population leads to increasing demand for sustained quality of life with the aid of novel implants. Patients expect fast healing and few complications after surgery. Increased biofunctionality and antimicrobial behavior of implants, in combination with supportive stem cell therapy, can meet these expectations. Recent research in the field of bone implants and the implementation of autologous mesenchymal stem cells in the treatment of bone defects is outlined and evaluated in this review. The article highlights several advantages, limitations and advances for metal-, ceramic- and polymer-based implants and discusses the future need for high-throughput screening systems used in the evaluation of novel developed materials and stem cell therapies. Automated cell culture systems, microarray assays or microfluidic devices are required to efficiently analyze the increasing number of new materials and stem cell-assisted therapies. Approaches described in the literature to improve biocompatibility, biofunctionality and stem cell differentiation efficiencies of implants range from the design of drug-laden nanoparticles to chemical modification and the selection of materials that mimic the natural tissue. Combining suitable implants with mesenchymal stem cell treatment promises to shorten healing time and increase treatment success. Most research studies focus on creating antibacterial materials or modifying implants with antibacterial coatings in order to address the increasing number of complications after surgeries that are mostly caused by bacterial infections. Moreover, treatment of multiresistant pathogens will pose even bigger challenges in hospitals in the future, according to the World Health Organization (WHO). These antibacterial materials will help to reduce infections after surgery and the number of antibiotic treatments that contribute to the emergence of new multiresistant pathogens, whilst the antibacterial implants will help reduce the amount of antibiotics used in clinical treatment.

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Antibacterial effect of nanometer‐size grafted layer of quaternary ammonium polymer on poly(ether ether ketone) substrate

Cited by 12 publications

References 66 publications

Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface

Antifouling Silicone Hydrogel Contact Lenses with a Bioinspired 2-Methacryloyloxyethyl Phosphorylcholine Polymer Surface

Recent Innovations in Bacterial Infection Detection and Treatment

Challenges in Bone Tissue Regeneration: Stem Cell Therapy, Biofunctionality and Antimicrobial Properties of Novel Materials and Its Evolution

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