Antibacterial effect of resin based root canal sealer antibiotic combination against enterococcus faecalis - an invitro study

Abstract

AIM: To evaluate and compare the antibacterial effect of AH plus, epiphany root canal sealer - with or without Amoxicillin and Doxycycline against E. faecalis (An in vitro study). METHODOLOGY: Freshly mixed sealers with or without antibiotics were placed in agar plates inoculated with E.faecalis and incubated for 24hrs at 370C under aerobic condition and zone of inhibition measured at 1st, 3rd, 5th& 7th day. RESULTS: Antibacterial action of AH Plus sealer was better than Epiphany with/without antibiotics at all time intervals. The antibacterial action of AH Plus – Doxycycline combination was twice and AH Plus – Amoxicillin combination was thrice compared to AH plus sealer alone. Antibacterial action of Epiphany – Doxycycline combination was thrice and Epiphany - Amoxicillin combination was four times greater compared to Epiphany sealer. CONCLUSION: Sealer – Amoxicillin combination showed better antibacterial action compared to sealer – Doxycycline combination.