Many Drugs have been used as controlling measures for chronic respiratory diseases recently in the poultry farms. Drugs are not accepted due to the high cost, residual effects on human and not covering all pathogenic species. One of the ways that has been very much accepted nowadays is to use natural compounds and their active ingredients to treat the chronic respiratory diseases. In this research, we investigated the effect of tylosin and Respofeed (unique combination of essential oils and natural active ingredients). Samples were collected 21st, 27th and 35th day after the treatments and four various growth parameters (clinical scores, Air sac lesions, mortality and body weight) were assessed. All growth parameters were best with the group 4 which was treated with Respofeed. The present study was akin to the findings of [20,21,22,23], who reported that volatile oils helps to treat CRD, improve body weight gain and reduces lesion scores.