Antibacterial efficacy and discolouration potential of antibiotic pastes with macrogol for regenerative endodontic therapy

Almeida, Mariana Porciuncula de; Neto, Miguel Angelo da Cunha; Pinto, Karem Paula; Fidel, Sandra Rivera; Silva, Emmanuel João Nogueira Leal; Sassone, Luciana Moura

doi:10.1111/aej.12438

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…Calcium hydroxide is the most popular intracanal medication for necrotic weeping cases and in revitalization procedures followed by the triple antibiotic mix which gained popularity in early cases of reported revascularization of immature necrotic teeth, then it was replaced by the double antibiotic mix to avoid the discoloration of the minocycline (12) .…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility of neem oil implanted in rats subcutaneous tissue versus different intracanal medications used in revitalization of necrotic teeth

Adam,

Abdelsalam,

Hegazy

et al. 2024

Egyptian Dental Journal

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Aim of the study: to investigate over the course of two time periods the biocompatibility through reaction of rats' subcutaneous tissue to three different intracanal medications (Neem oil, double antibiotic paste (DAP), and calcium hydroxide Ca (OH)2).Methodology: Forty-eight Albino rats were distributed into four groups according to the type of intracanal medicament (n = 12): Ca(OH) 2 , Double antibiotic paste (DAP), Neem oil and a control group. Each group was further subdivided into two subgroups according to the time interval. Polyethylene tubes injected with one of the experimental medicaments were implanted into the dorsal subcutaneous tissues of the rats while empty tubes served as controls. After 7 and 21 days the implants with the surrounding tissue were excised. Qualitative and quantitative analysis were carried out for the stained histological sections. Statistical analysis was performed using Kruskal-Wallis test to compare between the groups and Wilcoxon signed-rank test to analyze the changes by time within each group.Results: At 7 days: Ca(OH) 2 group was associated with a severe significant inflammatory reaction followed by Neem oil which had a moderate inflammatory reaction, the difference was statistically significant. At 21 days, the severity of inflammation decreased significantly in all groups. DAP had the lowest inflammatory reaction with no significant difference between it and the control group at 7 and 21 days. ConclusionsThe severity of the inflammatory reaction decreased over time in all groups. DAP could be considered the most biocompatible agent followed by Neem oil.

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Section: Discussionmentioning

confidence: 99%

Biocompatibility of neem oil implanted in rats subcutaneous tissue versus different intracanal medications used in revitalization of necrotic teeth

Adam,

Abdelsalam,

Hegazy

et al. 2024

Egyptian Dental Journal

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“…Dentin comprises the bulk of tooth tissue and is organized with thousands of canals and dentin tubules arranged from the inner pulp chamber as sunrays. The number of dentin tubules is about 18,000-21,000 per mm 2 . The odontoblastic membrane bends outwards, creating cellular processes that infiltrate the dentin tubules 8 .…”

Section: The Vital Pulp Tissuesmentioning

confidence: 99%

Regenerative Endodontics by Cell Homing: A Review of Recent Clinical trials

Yan¹,

Deus²,

Kristoffersen³

et al. 2023

Journal of Endodontics

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“…Its goal is to maintain the teeth's sensitivity and vitality. Root maturation is the primary clinical advantage [ 2 ]. Regenerative endodontics has become a viable alternative for treating teeth that are non-vital.…”

Section: Introductionmentioning

confidence: 99%

Platelet Power: Revitalizing Endodontics With Scaffolds

Hirani,

Chandak,

Agrawal

et al. 2024

Cureus

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This article provides an overview of a biologically based method for restoring damaged tooth structures and pulp tissues known as regenerative endodontics. It explores the concept of regenerative endodontics, its tissue engineering approach, and its application in maintaining vitality. The article discusses the significance of the factors affecting growth, scaffolds, and stem cells being the three tissue engineering components involved in the regeneration of pulp tissues. It also delves into the classification of scaffolds and the role of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) as biological scaffolds. The methodology section details the search process for relevant studies, and the review section presents research findings associated with PRF and its application in regeneration and repair of tissue. The article concludes by highlighting the potential of advanced PRF and injectable PRF in regenerative endodontics, with a focus on their impact on tissue regeneration and healing.

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Antibacterial efficacy and discolouration potential of antibiotic pastes with macrogol for regenerative endodontic therapy

Cited by 6 publications

References 27 publications

Biocompatibility of neem oil implanted in rats subcutaneous tissue versus different intracanal medications used in revitalization of necrotic teeth

Biocompatibility of neem oil implanted in rats subcutaneous tissue versus different intracanal medications used in revitalization of necrotic teeth

Regenerative Endodontics by Cell Homing: A Review of Recent Clinical trials

Platelet Power: Revitalizing Endodontics With Scaffolds

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