Antibacterial efficacy of Azadirachta indica, Mimusops elengi and 2% CHX on multispecies dentinal biofilm

Mistry, Kunjal S; Sanghvi, Zarna; Parmar, Girish; Shah, Samir; Pushpalatha, Kasukurthi

doi:10.4103/0972-0707.168810

Cited by 32 publications

(21 citation statements)

References 32 publications

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“…Ethanolic extract of Neem leaf demonstrated inhibitory effect on Methicillin-resistant Staphylococcus aureus biofilm by decreasing its ability to form large clusters [41]. The methanolic extract of Neem proved robust antimicrobial activity against polymicrobial dentinal biofilms of common endodontic pathogens, such as Staphylococcus aureus, Streptococcus mutans, Enterococcus faecalis, and Candida albicans [42]. In addition, Neem extract showed significant anti-inflammatory activity in vitro [43].…”

Section: Methodsmentioning

confidence: 98%

Functional Bioglass—Biopolymer Double Nanostructure for Natural Antimicrobial Drug Extracts Delivery

et al. 2020

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Aseptic loosening and periprosthetic infections are the main causes of implant failure. Strategies to mitigate this drawback are therefore mandatory to avoid primary and revision replacement surgeries. A functional bioapatite–biopolymer double nanostructure fabricated by matrix-assisted pulsed laser evaporation to prevent infection of orthopedic and dental implants could promote osseointegration and ensure controlled delivery of natural antimicrobial drugs. The synthesized nanostructure consists of two overlapping layers, the lower from a biocompatible polymer for anticorrosive protection, and the upper of bioactive glass incorporating antimicrobial plant extract, acting as a potential drug delivery system. Morphology, composition, adherence, ability for drug delivery and biological properties (cytotoxicity and antimicrobial effect) were studied. Structures proved compact and stable, conserving a remarkable drug delivery ability for more than 21 days, i.e., enough to ensure long-term microbes’ eradication.

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Section: Methodsmentioning

confidence: 98%

Functional Bioglass—Biopolymer Double Nanostructure for Natural Antimicrobial Drug Extracts Delivery

et al. 2020

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“…It also decreases intramitochondrial levels of acetyl CoA and acid soluble CoA esters and reduces the mitochondrial ATP content. [63,[78][79][80].…”

Section: Toxicity Testing On Neem Productsmentioning

confidence: 99%

“…Nimbidin studies in rat models are shown to produce sub-acute toxicity in adult rats after daily administration of 25, 50 or 100 mg/kg for six weeks [4,79]. A significant hypoglycaemic and spermicidal activity was observed by feeding nimbidin to fasting rabbits.…”

Section: Toxicity Testing On Neem Productsmentioning

confidence: 99%

The Potential Pharmacological and Medicinal Properties of Neem (Azadirachta indica A. Juss) in the Drug Development of Phytomedicine

Tembe-Fokunang

Fokunang

Kaba³

et al. 2019

JOCAMR

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An understanding of the chemistry of the secondary metabolites of neem plant (Azadirachta indica A. Juss) is essential and important due to its medicinal properties. Several studies have been done on the biological and pharmacological activities with a considerable progress made with respect to its biological activity and medicinal uses. The neem safety is known from its long communal ethno-pharmacological uses as a category one herbal product. It is readily available with great access to the local population at low cost and environmentally friendly. This paper attempts to give an insight into the biological activities of some of the compounds isolated, pharmacological actions of the extract, clinical studies and medicinal applications along with their safety evaluations. Issues on the active chemical constituents of various formulations, commercially available neem products, are also mentioned along with their respective application.

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“… 20 Mistry et al 21 checked the antimicrobial activity of methanolic extracts of Azadirachta indica (Neem) and Mimusops elengi (Bakul) on multispecies biofilm of streptococcus mutans, enterococcus faecalis, staphylococcus aureus and candida albicans , by using in vitro dentin disinfection model. 21 Saline was used as a negative control, and 2% chlorohexidine was used as positive control. Both plant extracts were effective as antimicrobial agents when compared to negative control.…”

Section: Cleaning and Disinfectionmentioning

confidence: 99%

Natural products in endodontics

Al‐Madi

Almohaimede

2018

SMJ

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Herbal remedies are used throughout the world, either in earlier or in recent times. The number of studies on this alternative therapeutic system increased in the last decades. In this paper, the relevant literature on the use of natural products in root canal therapy is revised from a MEDLINE database search. The uses of medicinal plants in endodontics include cleaning and disinfection of root canals, intracanal medicaments between appointments, sealer cements, and for removal of obturation material. Other studies showed the effect of natural products in pulpal and dentin repair. Their use is anecdotal, and their effectiveness showed to be variable and is always compared to the chemical standards currently being used. Alkaloids, coumarins, saponins, and flavonoids are aromatic substances that are produced by plants and evaluated for their therapeutic potential. Further investigation into benefits of natural products is warranted.

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Antibacterial efficacy of Azadirachta indica, Mimusops elengi and 2% CHX on multispecies dentinal biofilm

Cited by 32 publications

References 32 publications

Functional Bioglass—Biopolymer Double Nanostructure for Natural Antimicrobial Drug Extracts Delivery

Functional Bioglass—Biopolymer Double Nanostructure for Natural Antimicrobial Drug Extracts Delivery

The Potential Pharmacological and Medicinal Properties of Neem (Azadirachta indica A. Juss) in the Drug Development of Phytomedicine

Natural products in endodontics

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