Antibacterial efficacy of ciprofloxacin in a case of endocarditis due to Cardiobacterium hominis

Aortic homograft endocarditis caused by Cardiobacterium hominis and complicated by agranulocytosis due to ceftriaxone

“…We believe that the early detection of agranulocytosis and immediate cessation of ceftriaxone led to a much shorter duration of agranulocytosis of only 10 days when compared to the first episode 12 years ago when agranulocytosis persisted for 3 weeks. The antibacterial efficacy of ciprofloxacin in one case of endocarditis due to C hominis had been previously reported by Vogt et al 24 The American Heart Association (AHA) also suggest that fluoroquinolone can be considered as alternative regimen in patients unable to tolerate betalactam treatment 16. The current recommendation regarding duration of treatment is a 4-week intravenous course with a third-generation cephalosporin for native valve endocarditis, and a 6-week course with prosthetic valves 17.…”

Cardiobacterium hominis endocarditis: two cases and a review of the literature

“…Thirteen non-English-language cases from 12 manuscripts were not included. Two cases lacked sufficient clinical data for analysis [6,43]. Including our two cases, a total of 61 cases were reviewed.…”

Ciprofloxacin for the treatment of Cardiobacterium hominis prosthetic valve endocarditis

“…Patients with endocarditis who are unable to tolerate first line therapy can be treated with a fluoroquinolone (ciprofloxacin, levofloxacin, or moxifloxacin) for 6 weeks based on limited evidence [ 2 ]. There are only six published case reports of Cardiobacterium hominis that utilize ciprofloxacin as part of combination therapy or as salvage therapy [ [4] , [5] , [6] , [7] , [8] , [9] ] ( Table 1 ). Clinical cure was achieved in 5 of the 6 patients [ [4] , [5] , [6] , [7] , [8] ] with surgical intervention in 3 patients [ [7] , [8] , [9] ].…”

“…There are only six published case reports of Cardiobacterium hominis that utilize ciprofloxacin as part of combination therapy or as salvage therapy [ [4] , [5] , [6] , [7] , [8] , [9] ] ( Table 1 ). Clinical cure was achieved in 5 of the 6 patients [ [4] , [5] , [6] , [7] , [8] ] with surgical intervention in 3 patients [ [7] , [8] , [9] ]. In 4 cases, ciprofloxacin was combined with either rifampin, ceftriaxone, ceftriaxone and gentamicin, or penicillin, gentamicin, and imipenem-cilastatin [ [5] , [6] , [8] , [9] ].…”