Antibacterial efficacy of the grape seed extract as an irrigant for root canal preparation

D'aviz, Fernando Soveral; Lodi, Enrico; Souza, Matheus Albino; Farina, Ana Paula; Cecchin, Doglas

doi:10.14744/eej.2019.85057

Cited by 3 publications

(17 citation statements)

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“…The material employed in this study was WMTA, which is made up of 80% Portland cement and 20% calcium sulfate-free bismuth oxide to reduce setting time [7]. GSE was also used as it showed promising results when used as an endodontic irrigant and before the application of composite [9], [10], [11], [12]. Subsequently, the present study investigated a new dental material (combination of WMTA and GSE) that combines WMTA biocompatibility with acceptable setting time, handling characteristics, chemical properties, and antioxidant capabilities of GSE, and compared it to each of its components independently.…”

Section: Discussionmentioning

confidence: 99%

“…The sample size was obtained using the G* power software statistical analysis (Latest ver. 3.1.9.7; Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany) according to D'Aviz et al [11]. One hundred and twenty teeth were sufficient to detect the effect size of 0.4 and a power (1-β) of 80% at a significant level of (α) level of 0.05.…”

Section: Sample Size Calculationmentioning

confidence: 99%

“…Due to its antioxidant properties, GSE considerably increased the bond strength of composite resin to bleached enamel following bleaching [10]. Recent research used GSE as an endodontic irrigant due to its antimicrobial action and it was comparable to 2% chlorhexidine gel [11]. Interestingly, GSE maintained the dentin microhardness [12].…”

Section: Introductionmentioning

confidence: 99%

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Push-Out Bond Strength and Dentinal Penetration of a Novel Herbal-Based Pulp Capping Agent: An In vitro Study

Hamdy

Elgendi

Sharaan

2022

Open Access Maced J Med Sci

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Background: Pulp capping agents should have proper sealing effect to enhance dental pulp tissue healing. Aim: The purpose of this study was to compare the effectiveness of grape seed extract (GSE) and Mineral trioxide aggregate (MTA) to penetrate to dentin and their push-out bond strength at two time intervals (1 and 3 months) when used as pulp capping agents either singly or combined to each other. Materials and Methods: This study was conducted on 120 human single-rooted anterior teeth. Sixty dentin discs were randomly divided into three groups (n=20) based on the material used; MTA, GSE, and a combination of MTA and GSE. A universal testing machine was used to determine the push-out bond strength for one and three months. At the same time intervals, extra 60 teeth with the same groups were utilized to quantify the degree of capping material penetration within the dentinal tubules using scanning electron microscopy (SEM). ANOVA with multiple comparison Post hoc test was used to evaluate the data where the p value was < 0.05. Results: MTA had the highest push-out bond strength and penetration depth measurement into dentinal tubules at one month, followed by MTA combined with GSE, while GSE had the lowest push-out bond strength and penetration depth measurement. Nevertheless, GSE had the greatest values in both tests at 3 months, followed by MTA, while MTA coupled with GSE had the lowest value in both tests. Conclusion: Push out bond strength and dentinal penetration depth were improved with time except for the MTA group testing its dentinal penetration depth. GSE shows good push out bond strength and dentinal penetration depth.

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Section: Discussionmentioning

confidence: 99%

Section: Sample Size Calculationmentioning

confidence: 99%

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Push-Out Bond Strength and Dentinal Penetration of a Novel Herbal-Based Pulp Capping Agent: An In vitro Study

Hamdy

Elgendi

Sharaan

2022

Open Access Maced J Med Sci

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“…The GSE powder was made by hot water extraction, and its molecular weight is 590.581 g/mol, corresponding to the manufacturer's recommendation [11].…”

Section: Preparation Of the Gsementioning

confidence: 99%

“…Due to its anti-oxidant properties, GSE considerably increased the bond strength of composite resin to bleached enamel following bleaching [10]. Recent research used GSE as an endodontic irrigant due to its antimicrobial action and it was comparable to 2% chlorhexidine gel [11]. Interestingly, GSE maintained the dentin microhardness [12].…”

Section: Introductionmentioning

confidence: 99%

Push out bond strength and dentinal penetration of a novel herbal based pulp capping agent: An in Vitro study

Hamdy

gendy

Sharaan

2022

Preprint

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Background: The purpose of this study was to compare the effectiveness of grape seed extract (GSE) and Mineral trioxide aggregate (MTA) to penetrate to dentin and their push-out bond strength at two time intervals (1 and 3 months) when used as pulp capping agents either singly or combined to each other. Materials and Methods:This study was conducted on 120 human single-rooted anterior teeth. Sixty dentin discs were randomly divided into three groups (n=20) based on the material used; MTA, GSE, and a combination of MTA and GSE. A universal testing machine was used to determine the push-out bond strength for one and three months. At the same time intervals, extra 60 teeth with the same groups were utilized to quantify the degree of capping material penetration within the dentinal tubules using scanning electron microscopy (SEM). ANOVA with multiple comparison Post hoc test was used to evaluate the data where the p value was < 0.05. Results: MTA had the highest push-out bond strength and penetration depth measurement into dentinal tubules at one month, followed by MTA combined with GSE, while GSE had the lowest push-out bond strength and penetration depth measurement. Nevertheless, GSE had the greatest values in both tests at 3 months, followed by MTA, while MTA coupled with GSE had the lowest value in both tests. Conclusion: Push out bond strength and dentinal penetration depth were improved with time except for the MTA group testing its dentinal penetration depth. GSE shows good push out bond strength and dentinal penetration depth.

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Root canal disinfection and maintenance of the remnant tooth tissues by using grape seed and cranberry extracts

et al. 2022

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The purpose of this study was to perform an integrative review on the effects of cranberry and grape seed extracts concerning the disinfection of root canals maintaining the strength of the remnant tooth tissues' structure.A bibliographical search was carried out on the PubMed electronic platform using the following key terms: cranberry, grape seed, vaccinium macrocarpon, proanthocyanidin, antibacterial, antimicrobial, decontamination, disinfection, bacteria removal, bacteria eradication, bacteria elimination, endodontic, root canal, faecalis, and strength. The inclusion criteria involved articles published in the English language, until March 29 th , 2022, reporting the antibacterial effect of grape seed and cranberry extracts.Of 185 studies identified, 13 studies were selected for the present review. The grape seed extract (GSE), composed of proanthocyanidins, showed an antioxidant activity against the main bacteria found in endodontic secondary infection. The percentage of bacteria removal was recorded at around 96.97% by using GSE. Studies on cranberry extracts, which are composed of proanthocyanidins, revealed antimicrobial effects against bacteria related to as periodontitis and dental caries. Additionally, GSE or cranberry allowed the dentin collagen cross-linking that preserved the 3D collagen network leading to the maintenance of the strength of the remnant tooth structure.However, the contaminated smear layer could not be removed by using only GSE or cranberry.3 Cranberry extracts and GSE revealed a significant antimicrobial activity in endodontic disinfection without changing the mechanical properties of the remnant dentin tissues. Furthermore, those components can be associated with traditional compounds to enhance their antimicrobial effects and eliminate the smear layer.

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Antibacterial efficacy of the grape seed extract as an irrigant for root canal preparation

Cited by 3 publications

References 0 publications

Push-Out Bond Strength and Dentinal Penetration of a Novel Herbal-Based Pulp Capping Agent: An In vitro Study

Push-Out Bond Strength and Dentinal Penetration of a Novel Herbal-Based Pulp Capping Agent: An In vitro Study

Push out bond strength and dentinal penetration of a novel herbal based pulp capping agent: An in Vitro study

Root canal disinfection and maintenance of the remnant tooth tissues by using grape seed and cranberry extracts

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